sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1grh	FAD	Glutathione reductase, mitochondrial	1.8.1.7

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1grh	FAD	Glutathione reductase, mitochondrial	1.8.1.7	1.000
3grs	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.834
1grg	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.824
4gr1	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.805
1gre	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.778
1gra	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.668
1k4q	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.602
3sqp	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.546
1gsn	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.503
1bwc	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.499
3dk9	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.463
3dgz	FAD	Thioredoxin reductase 2, mitochondrial	1.8.1.9	0.460
3dk8	FAD	Glutathione reductase, mitochondrial	1.8.1.7	0.453