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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gq2NAPNADP-dependent malic enzyme1.1.1.40

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1gq2NAPNADP-dependent malic enzyme1.1.1.401.000
1pj2NAINAD-dependent malic enzyme, mitochondrial1.1.1.380.560
1do8NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.551
1efkNADNAD-dependent malic enzyme, mitochondrial1.1.1.380.537
1eflNADNAD-dependent malic enzyme, mitochondrial1.1.1.380.536
1gz4ATPNAD-dependent malic enzyme, mitochondrial1.1.1.380.529
1pj3NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.527
1pj4ATPNAD-dependent malic enzyme, mitochondrial1.1.1.380.512
2xpwOTCTetracycline repressor protein class D/0.447
2vkvTDCTetracycline repressor protein class D/0.440