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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gjrFADFerredoxin--NADP reductase1.18.1.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1gjrFADFerredoxin--NADP reductase1.18.1.21.000
3zc3FADFerredoxin--NADP reductase1.18.1.20.654
4c43FADFerredoxin--NADP reductase1.18.1.20.628
4bprFADFerredoxin--NADP reductase1.18.1.20.625
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.621
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.621
1w35FADFerredoxin--NADP reductase1.18.1.20.615
2rc6FADFerredoxin--NADP reductase/0.614
1gawFADFerredoxin/0.611
1qgyFADFerredoxin--NADP reductase1.18.1.20.610
1gaqFADFerredoxin/0.607
1h85FADFerredoxin--NADP reductase1.18.1.20.607
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.605
3vo2FADFerredoxin--NADP reductase/0.604
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.603
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.601
1sm4FADFerredoxin--NADP reductase/0.595
1queFADFerredoxin--NADP reductase1.18.1.20.594
2b5oFADFerredoxin--NADP reductase1.18.1.20.590
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.586
1w87FADFerredoxin--NADP reductase1.18.1.20.584
1e63FADFerredoxin--NADP reductase1.18.1.20.582
1h42FADFerredoxin--NADP reductase1.18.1.20.582
1bjkFADFerredoxin--NADP reductase1.18.1.20.580
3w5uFADFerredoxin/0.580
1qh0FADFerredoxin--NADP reductase1.18.1.20.579
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.572
1go2FADFerredoxin--NADP reductase1.18.1.20.571
3fpkFADFerredoxin-NADP reductase/0.563
1e64FADFerredoxin--NADP reductase1.18.1.20.562
1ewyFADFerredoxin--NADP reductase1.18.1.20.560
1ogjFADFerredoxin--NADP reductase1.18.1.20.560
3zbtFADFerredoxin--NADP reductase1.18.1.20.556
1qgzFADFerredoxin--NADP reductase1.18.1.20.554
1e62FADFerredoxin--NADP reductase1.18.1.20.553
1ogiFADFerredoxin--NADP reductase1.18.1.20.544
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.539
2ok8FADFerredoxin--NADP reductase, apicoplast/0.534
1b2rFADFerredoxin--NADP reductase1.18.1.20.531
1gr1FADFerredoxin--NADP reductase1.18.1.20.527
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.525
3qfsFADNADPH--cytochrome P450 reductase/0.523
2rc5FADFerredoxin--NADP reductase/0.517
1ja1FADNADPH--cytochrome P450 reductase/0.515
1amoFADNADPH--cytochrome P450 reductase/0.514
3jqrFADFerredoxin--NADP reductase, apicoplast/0.503
1f20FADNitric oxide synthase, brain1.14.13.390.492
1j9zFADNADPH--cytochrome P450 reductase/0.491
4yaoFADNADPH--cytochrome P450 reductase/0.483
3qftFADNADPH--cytochrome P450 reductase/0.481
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.480
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.478
3ojxFADNADPH--cytochrome P450 reductase/0.475
3qfcFADNADPH--cytochrome P450 reductase/0.474
2geuCOKPantothenate kinase2.7.1.330.471
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.470
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.470
5ah5LSSLeucine--tRNA ligase/0.470
4q0kGA3Phytohormone-binding protein/0.468
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.467
1a8pFADFerredoxin--NADP reductase/0.466
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.466
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.466
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.463
5a4vQUEGlutathione S-transferase F22.5.1.180.463
1cqxFADFlavohemoprotein/0.462
2vnjFADNADPH:ferredoxin reductase/0.462
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.462
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.461
4esoNAPPutative oxidoreductase/0.460
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.458
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3otwCOAPhosphopantetheine adenylyltransferase/0.457
2y0468HBeta-1 adrenergic receptor/0.456
1fdrFADFerredoxin--NADP reductase1.18.1.20.455
1x1bSAHC-20 methyltransferase/0.455
2ejzSAHDiphthine synthase/0.455
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.455
1ja1FMNNADPH--cytochrome P450 reductase/0.453
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.453
5dp2NAPCurF/0.453
1g63FMNEpidermin decarboxylase4.1.10.452
2vnkFADNADPH:ferredoxin reductase/0.452
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.451
1z41FMNNADPH dehydrogenase/0.451
3c1oNAPEugenol synthase/0.451
4fk8FADFerredoxin--NADP reductase/0.451
4h1e10JBeta-secretase 13.4.23.460.451
2bgiFADNADPH:ferredoxin reductase/0.450
3h3r14HCollagen type IV alpha-3-binding protein/0.450
4b4vL34Bifunctional protein FolD/0.450
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3h3t16HCollagen type IV alpha-3-binding protein/0.449
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.448
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.448
2w6zL21Biotin carboxylase6.3.4.140.448
4b68FADL-ornithine N(5)-monooxygenase/0.448
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.447
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.447
3ojxFMNNADPH--cytochrome P450 reductase/0.447
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.447
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.447
4q7f3D1Uncharacterized protein/0.447
2zevIPEGeranylgeranyl pyrophosphate synthase/0.446
1gky5GPGuanylate kinase2.7.4.80.445
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
3af1GDPPantothenate kinase2.7.1.330.445
3fktSIIBeta-secretase 13.4.23.460.445
4uugPXGBranched-chain amino acid aminotransferase, putative/0.444
2e0nSAHPrecorrin-2 C20-methyltransferase/0.443
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.443
4b7754MBeta-secretase 13.4.23.460.443
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.443
4wx2F6FTryptophan synthase alpha chain/0.443
4wx2F6FTryptophan synthase beta chain4.2.1.200.443
1qzyTDEMethionine aminopeptidase 2/0.442
3h3sH15Collagen type IV alpha-3-binding protein/0.442
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.442
4j0v1H7Beta-secretase 13.4.23.460.442
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.442
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.441
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.441
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.441
4b4w9L9Bifunctional protein FolD/0.440
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440