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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gerFADGlutathione reductase1.8.1.7

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1gerFADGlutathione reductase1.8.1.71.000
1geuFADGlutathione reductase1.8.1.70.564
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.554
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.539
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.533
3grsFADGlutathione reductase, mitochondrial1.8.1.70.532
1grhFADGlutathione reductase, mitochondrial1.8.1.70.529
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.520
1febFADTrypanothione reductase1.8.1.120.515
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.502
1getFADGlutathione reductase1.8.1.70.500
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.488
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.482
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.472
1bzlFADTrypanothione reductase1.8.1.120.471
1grgFADGlutathione reductase, mitochondrial1.8.1.70.469
1greFADGlutathione reductase, mitochondrial1.8.1.70.466
2eq9FADDihydrolipoyl dehydrogenase/0.463
2r9zFADGlutathione amide reductase/0.463
4j56FADThioredoxin reductase 21.8.1.90.456
4nevFADTrypanothione reductase/0.455
4jq9FADDihydrolipoyl dehydrogenase/0.451
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.445
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.443
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.441