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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.252

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2521.000
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.519
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.514
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.499
4j7uNAPSepiapterin reductase1.1.1.1530.496
1ipeNDPTropinone reductase 21.1.1.2360.495
4hwkNAPSepiapterin reductase1.1.1.1530.493
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.491
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.489
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.488
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.485
4j7xNAPSepiapterin reductase1.1.1.1530.483
2dteNAIGlucose 1-dehydrogenase related protein/0.480
1x7gNAPPutative ketoacyl reductase1.3.10.475
5idwNAPShort-chain dehydrogenase/reductase SDR/0.475
3l77NJPShort-chain alcohol dehydrogenase/0.472
4bmvNAPShort-chain dehydrogenase/0.471
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.471
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.470
3tn7NJPShort-chain alcohol dehydrogenase/0.467
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.466
4dc1NDPPutative ketoacyl reductase1.3.10.466
1ae1NAPTropinone reductase 1/0.464
5jlaNADPutative short-chain dehydrogenase/reductase/0.464
1xg5NAPDehydrogenase/reductase SDR family member 11/0.460
3qrwNDPPutative ketoacyl reductase1.3.10.460
4qecNAPElxO/0.460
2bd0NAPSepiapterin reductase/0.459
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
1snyNAPLD36273p/0.457
2yutNAPPutative short-chain oxidoreductase/0.457
3s55NADPutative short-chain dehydrogenase/reductase/0.457
4gh5NADShort-chain dehydrogenase/reductase SDR/0.452
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.451
3wdsNADNADH-dependent quinuclidinone reductase/0.451
1oaaNAPSepiapterin reductase1.1.1.1530.450
1w4zNAPPutative ketoacyl reductase1.3.10.450
1x7hNDPPutative ketoacyl reductase1.3.10.450
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
1xkqNDPUncharacterized protein/0.448
2jahNDPClavaldehyde dehydrogenase/0.448
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3sjuNDPKeto reductase/0.447
1wntNAPL-xylulose reductase1.1.1.100.446
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.445
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.444
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.443
3ak4NADNADH-dependent quinuclidinone reductase/0.443
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.443
1pr9NAPL-xylulose reductase1.1.1.100.442
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.442
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.441
3toxNAPPutative oxidoreductase/0.441
3p19NDPPutative blue fluorescent protein/0.440
4yaiNAIC alpha-dehydrogenase/0.440