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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.21.000
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.809
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.655
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.651
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.639
1gawFADFerredoxin/0.620
3vo2FADFerredoxin--NADP reductase/0.619
3zc3FADFerredoxin--NADP reductase1.18.1.20.608
1gjrFADFerredoxin--NADP reductase1.18.1.20.603
1go2FADFerredoxin--NADP reductase1.18.1.20.603
1h85FADFerredoxin--NADP reductase1.18.1.20.598
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.595
3w5uFADFerredoxin/0.592
1qh0FADFerredoxin--NADP reductase1.18.1.20.590
4c43FADFerredoxin--NADP reductase1.18.1.20.590
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.581
1bjkFADFerredoxin--NADP reductase1.18.1.20.578
1qgyFADFerredoxin--NADP reductase1.18.1.20.575
3zbtFADFerredoxin--NADP reductase1.18.1.20.572
1gaqFADFerredoxin/0.571
1e64FADFerredoxin--NADP reductase1.18.1.20.570
1sm4FADFerredoxin--NADP reductase/0.570
4bprFADFerredoxin--NADP reductase1.18.1.20.570
1e63FADFerredoxin--NADP reductase1.18.1.20.563
2b5oFADFerredoxin--NADP reductase1.18.1.20.551
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.551
1w35FADFerredoxin--NADP reductase1.18.1.20.550
1h42FADFerredoxin--NADP reductase1.18.1.20.549
2rc6FADFerredoxin--NADP reductase/0.549
1ogiFADFerredoxin--NADP reductase1.18.1.20.547
1amoFADNADPH--cytochrome P450 reductase/0.546
1queFADFerredoxin--NADP reductase1.18.1.20.543
1ogjFADFerredoxin--NADP reductase1.18.1.20.537
1e62FADFerredoxin--NADP reductase1.18.1.20.533
1w87FADFerredoxin--NADP reductase1.18.1.20.533
3fpkFADFerredoxin-NADP reductase/0.532
1gr1FADFerredoxin--NADP reductase1.18.1.20.530
1qgzFADFerredoxin--NADP reductase1.18.1.20.528
4yaoFADNADPH--cytochrome P450 reductase/0.521
1ewyFADFerredoxin--NADP reductase1.18.1.20.518
1j9zFADNADPH--cytochrome P450 reductase/0.516
4y9uFADNADPH--cytochrome P450 reductase/0.510
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.509
1b2rFADFerredoxin--NADP reductase1.18.1.20.508
3qfsFADNADPH--cytochrome P450 reductase/0.508
2rc5FADFerredoxin--NADP reductase/0.503
3jqrFADFerredoxin--NADP reductase, apicoplast/0.503
2ok8FADFerredoxin--NADP reductase, apicoplast/0.501
5ah5LSSLeucine--tRNA ligase/0.492
1ja1FADNADPH--cytochrome P450 reductase/0.491
3qftFADNADPH--cytochrome P450 reductase/0.491
2piaFMNPhthalate dioxygenase reductase/0.486
4jtqNAPAldo-keto reductase family 1 member C2/0.478
3ojxFADNADPH--cytochrome P450 reductase/0.475
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.474
2vnjFADNADPH:ferredoxin reductase/0.473
3qe2FADNADPH--cytochrome P450 reductase/0.469
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.467
3opxU5PSuppressor of disruption of TFIIS/0.467
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.466
2uxoTACHTH-type transcriptional regulator TtgR/0.463
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.463
4fk8FADFerredoxin--NADP reductase/0.461
1f20FADNitric oxide synthase, brain1.14.13.390.460
4k1xFADNADPH:ferredoxin reductase/0.460
1w34FADFerredoxin--NADP reductase1.18.1.20.457
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.457
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.456
5k7uSAMN6-adenosine-methyltransferase 70 kDa subunit/0.456
3c1oNAPEugenol synthase/0.455
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.454
1tllFADNitric oxide synthase, brain1.14.13.390.453
2wp9CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.453
2wp9CBESuccinate dehydrogenase cytochrome b556 subunit/0.453
2hdjNDPAldo-keto reductase family 1 member C2/0.452
1a8pFADFerredoxin--NADP reductase/0.451
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.451
2vnkFADNADPH:ferredoxin reductase/0.451
1xe65FPPlasmepsin-23.4.23.390.449
3h3r14HCollagen type IV alpha-3-binding protein/0.449
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.449
1g6kNADGlucose 1-dehydrogenase1.1.1.470.448
3p0fBAUUridine phosphorylase 22.4.2.30.448
4bftZVTPantothenate kinase2.7.1.330.448
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.448
3q3cNADNAD-dependent L-serine dehydrogenase/0.447
4acxS8ZBeta-secretase 13.4.23.460.447
4b65FADL-ornithine N(5)-monooxygenase/0.447
4l1xNAPAldo-keto reductase family 1 member C2/0.447
2zevIPEGeranylgeranyl pyrophosphate synthase/0.446
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.445
4nv14TGFormyl transferase/0.445
1pkfEPDEpothilone C/D epoxidase1.140.444
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.444
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.444
1e7qNAPGDP-L-fucose synthase/0.443
2bgiFADNADPH:ferredoxin reductase/0.443
1sdwIYTPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.442
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3h3t16HCollagen type IV alpha-3-binding protein/0.442
3otwCOAPhosphopantetheine adenylyltransferase/0.442
4q0kGA3Phytohormone-binding protein/0.442
4ugaH4BNitric oxide synthase oxygenase1.14.13.1650.442
1bwsNDPGDP-L-fucose synthase/0.441
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.441
4bfxZVXPantothenate kinase2.7.1.330.441
1c9wNAPAldose reductase-related protein 2/0.440
1fdrFADFerredoxin--NADP reductase1.18.1.20.440
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.440
4q7f3D1Uncharacterized protein/0.440
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.440
4y7cFADNADPH--cytochrome P450 reductase/0.440