sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 1.000 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.685 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.639 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.634 | |
| 4k4j | 1O8 | Retinoic acid receptor RXR-alpha | / | 0.634 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.626 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.622 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.620 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.620 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.620 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.613 | |
| 3fc6 | REA | Retinoic acid receptor RXR-alpha | / | 0.609 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.606 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.598 | |
| 3fal | REA | Retinoic acid receptor RXR-alpha | / | 0.598 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.592 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.580 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.577 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.571 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.562 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.556 | |
| 2bxm | IMN | Serum albumin | / | 0.528 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.516 | |
| 2xvv | 9DN | Serum albumin | / | 0.513 | |
| 2xvw | 9NR | Serum albumin | / | 0.504 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.502 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.501 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.501 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.498 | |
| 2bxq | IMN | Serum albumin | / | 0.497 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.497 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.496 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.496 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.495 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.495 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.494 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.494 | |
| 3cse | N22 | Uncharacterized protein | / | 0.493 | |
| 3b9l | AZZ | Serum albumin | / | 0.492 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.490 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.489 | |
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.489 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.489 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1e7a | PFL | Serum albumin | / | 0.488 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.488 | |
| 2acw | UPG | Glycosyltransferase | / | 0.487 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.487 | |
| 2wpw | ACO | Orf14 | / | 0.486 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.486 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.486 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.486 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.485 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.485 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.485 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.485 | |
| 4boe | CLR | Japanin | / | 0.485 | |
| 4iae | 1DX | Alr2278 protein | / | 0.485 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.485 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.485 | |
| 1ppj | ANY | Cytochrome b | / | 0.484 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.484 | |
| 4apu | A2K | Progesterone receptor | / | 0.484 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.484 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.483 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.483 | |
| 3dol | GWI | Pol protein | / | 0.483 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.482 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.482 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.482 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.482 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.482 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.481 | |
| 4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.481 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.480 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.480 | |
| 4hw2 | 19H | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.480 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.480 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.479 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.479 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.479 | |
| 4iah | 1DX | Alr2278 protein | / | 0.479 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.479 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.479 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.478 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.478 | |
| 3htj | ET | EbrA repressor | / | 0.478 | |
| 4b4o | NDP | Epimerase family protein SDR39U1 | / | 0.478 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.477 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.477 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.477 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.477 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.476 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.476 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.476 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.476 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.475 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.475 | |
| 1pp9 | SMA | Cytochrome b | / | 0.475 | |
| 1sqb | AZO | Cytochrome b | / | 0.475 | |
| 1yin | CM3 | Estrogen receptor | / | 0.475 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.475 | |
| 3d5f | L41 | Peroxisome proliferator-activated receptor delta | / | 0.475 | |
| 3drr | R8E | Gag-Pol polyprotein | 2.7.7.49 | 0.475 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.475 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.475 | |
| 1wrl | TFP | Troponin C, slow skeletal and cardiac muscles | / | 0.474 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.474 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.474 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.474 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.474 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.473 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.473 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.473 | |
| 3gob | HXX | DdmC | / | 0.473 | |
| 3qly | 55V | Uncharacterized protein | / | 0.473 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.473 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.472 | |
| 2x23 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.472 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.472 | |
| 4a2j | AS0 | Progesterone receptor | / | 0.472 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.471 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.471 | |
| 3h1j | SMA | Cytochrome b | / | 0.471 | |
| 3r7c | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.471 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.471 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.471 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 1err | RAL | Estrogen receptor | / | 0.470 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.470 | |
| 1r9o | FLP | Cytochrome P450 2C9 | / | 0.470 | |
| 2p15 | EZT | Estrogen receptor | / | 0.470 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.470 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.470 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.470 | |
| 5dhg | DGV | Nociceptin receptor | / | 0.470 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.469 | |
| 1osv | CHC | Bile acid receptor | / | 0.469 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.469 | |
| 3il5 | B82 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.469 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.469 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.469 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.469 | |
| 3r6p | A8S | Abscisic acid receptor PYL10 | / | 0.469 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.469 | |
| 4l8u | 9AZ | Serum albumin | / | 0.469 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.469 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 1dv2 | ATP | Biotin carboxylase | 6.3.4.14 | 0.468 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.468 | |
| 2jfz | 003 | Glutamate racemase | / | 0.468 | |
| 2pnu | ENM | Androgen receptor | / | 0.468 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.468 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3imx | B84 | Glucokinase | 2.7.1.2 | 0.468 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.468 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.468 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.468 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.468 | |
| 4juf | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.468 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.468 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.468 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.467 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.467 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.467 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.467 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.467 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.467 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.467 | |
| 1ppj | SMA | Cytochrome b | / | 0.466 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.466 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.466 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.466 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.466 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.466 | |
| 1sqp | MYX | Cytochrome b | / | 0.465 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.465 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.465 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.465 | |
| 2wpx | ACO | Orf14 | / | 0.465 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.465 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.465 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.465 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.465 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.465 | |
| 2gyo | COA | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.464 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.464 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.464 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.464 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.464 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.464 | |
| 4klr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.464 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.463 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.463 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.463 | |
| 1ysx | 4EB | Serum albumin | / | 0.463 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.463 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 2rht | C1E | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.463 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.463 | |
| 3u2l | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.463 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.463 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.463 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.462 | |
| 1ezv | SMA | Cytochrome b | / | 0.462 | |
| 1iky | MSD | Gag-Pol polyprotein | 2.7.7.49 | 0.462 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.462 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.462 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.462 | |
| 2uzh | IPE | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.462 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.462 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.462 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.462 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.462 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.462 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.462 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 4egn | TWO | Cytochrome P450 | / | 0.462 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.461 | |
| 1c3e | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.461 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1ht8 | 34C | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.461 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.461 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.461 | |
| 3cxh | SMA | Cytochrome b | / | 0.461 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.461 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.461 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.461 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.460 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.460 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.460 | |
| 3bjh | NBB | Odorant binding protein ASP1 | / | 0.460 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.460 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.460 | |
| 3eel | 53T | Uncharacterized protein | / | 0.460 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta | / | 0.460 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta' | / | 0.460 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.460 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.460 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.459 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.459 | |
| 1fml | RTL | Retinol dehydratase | / | 0.459 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.459 | |
| 1q0q | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.459 | |
| 2bxo | OPB | Serum albumin | / | 0.459 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.459 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.459 | |
| 3cx5 | SMA | Cytochrome b | / | 0.459 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.459 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 3f82 | 353 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.459 | |
| 3fu9 | KIB | Laccase-1 | 1.10.3.2 | 0.459 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.459 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.459 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.459 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.459 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.458 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.458 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.458 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 3tk0 | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.458 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.458 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.458 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.458 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.458 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.458 | |
| 4hai | I23 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.458 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.458 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.458 | |
| 4mcv | 29K | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.458 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.458 | |
| 4ea3 | 0NN | Nociceptin receptor | / | 0.458 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.458 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.457 | |
| 1nde | MON | Estrogen receptor beta | / | 0.457 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.457 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.457 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.457 | |
| 2mm3 | CHO | Gastrotropin | / | 0.457 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.457 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.457 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.457 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.457 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.457 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.457 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.457 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.457 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.457 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.457 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.457 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.457 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.457 | |
| 4pd6 | URI | Nucleoside permease | / | 0.457 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.456 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 1khr | COA | Streptogramin A acetyltransferase | 2.3.1 | 0.456 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2cy2 | ACO | Probable acetyltransferase | / | 0.456 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.456 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.456 | |
| 2ovm | AS0 | Progesterone receptor | / | 0.456 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.456 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.456 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.456 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.456 | |
| 3f88 | 3HT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.456 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.456 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.456 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.456 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.456 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.456 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.456 | |
| 4h0x | NAD | Iota toxin component Ia | / | 0.456 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.456 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.456 | |
| 4xiv | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.456 | |
| 1aqb | RTL | Retinol-binding protein 4 | / | 0.455 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 1kb9 | SMA | Cytochrome b | / | 0.455 | |
| 1mb9 | ATP | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.455 | |
| 1ohr | 1UN | V-1 PROTEASE protein | / | 0.455 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.455 | |
| 2iog | IOG | Estrogen receptor | / | 0.455 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.455 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.455 | |
| 3cy3 | JN5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 3m8c | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.455 | |
| 3s1c | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.455 | |
| 3v1m | HPK | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.455 | |
| 3wxy | COA | Uncharacterized protein | / | 0.455 | |
| 4a9h | TVP | Bromodomain-containing protein 2 | / | 0.455 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.455 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.455 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.455 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.455 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.455 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.455 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.455 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.454 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 2j0v | GDP | Rac-like GTP-binding protein ARAC7 | / | 0.454 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.454 | |
| 2puj | HPZ | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.454 | |
| 2qe4 | JJ3 | Estrogen receptor | / | 0.454 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.454 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.454 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.454 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4la0 | 198 | Serum albumin | / | 0.454 | |
| 5d7p | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.454 | |
| 1bif | AGS | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.453 | |
| 1c2t | NHS | Phosphoribosylglycinamide formyltransferase | / | 0.453 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.453 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.453 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.453 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.453 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.453 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.453 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.453 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.453 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.453 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.453 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.453 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.453 | |
| 3tgu | WF3 | Cytochrome b | / | 0.453 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.453 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.453 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.453 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.453 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.453 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.453 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.453 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.452 | |
| 1p93 | DEX | Glucocorticoid receptor | / | 0.452 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.452 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.452 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.452 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.452 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.452 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.452 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.452 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.452 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.452 | |
| 4agu | D15 | Cyclin-dependent kinase-like 1 | / | 0.452 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.452 | |
| 5dq8 | FLF | Transcriptional enhancer factor TEF-4 | / | 0.452 | |
| 1kyo | SMA | Cytochrome b | / | 0.451 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.451 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.451 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 3ffi | 3OB | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.451 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.451 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.451 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.451 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4an9 | 2P7 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.451 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.451 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.451 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.451 | |
| 4li7 | 1XP | Tankyrase-1 | 2.4.2.30 | 0.451 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.451 | |
| 4okt | 198 | Androgen receptor | / | 0.451 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.451 | |
| 5i2h | AGI | O-methyltransferase family 2 | / | 0.451 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.451 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.450 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.450 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.450 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.450 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.450 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.450 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.450 | |
| 2ayl | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.450 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.450 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.450 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.450 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.450 | |
| 3bgi | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.450 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.450 | |
| 4bmp | FMN | Protein NrdI | / | 0.450 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 4h4z | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.450 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4i2q | 1BT | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.450 | |
| 1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.449 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.449 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.449 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.449 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.449 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.449 | |
| 2c9e | PID | Peridinin-chlorophyll a protein, high-salt form | / | 0.449 | |
| 2fhj | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.449 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.449 | |
| 2gpu | OHT | Estrogen-related receptor gamma | / | 0.449 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.449 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.449 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.449 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.449 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.449 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.449 | |
| 3orm | AGS | Serine/threonine protein kinase | / | 0.449 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.449 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 3t37 | FAD | Pyridoxine 4-oxidase | / | 0.449 | |
| 4i0r | 1B4 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.449 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.449 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.449 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.449 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.449 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.449 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.449 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.449 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.448 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.448 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.448 | |
| 1r2j | FAD | FkbI | / | 0.448 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.448 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.448 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 2y00 | Y01 | Beta-1 adrenergic receptor | / | 0.448 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.448 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.448 | |
| 3n8x | NIM | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.448 | |
| 3n8z | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.448 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.448 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.448 | |
| 3u2m | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.448 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.448 | |
| 5cp8 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 1c2t | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.447 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1m8d | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.447 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 1xkk | FMM | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 2b5j | 3AC | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.447 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.447 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.447 | |
| 2yiu | SMA | Cytochrome b | / | 0.447 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.447 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3eek | 53S | Uncharacterized protein | / | 0.447 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.447 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.447 | |
| 3rpn | GTX | Glutathione S-transferase kappa 1 | 2.5.1.18 | 0.447 | |
| 3sd0 | TSK | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.447 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.447 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.447 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.447 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.447 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.447 | |
| 4fox | D16 | Thymidylate synthase ThyA | / | 0.447 | |
| 4hxy | NDP | Plm1 | / | 0.447 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.447 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.447 | |
| 4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.447 | |
| 5fsx | ADP | Uncharacterized protein | / | 0.447 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1eio | GCH | Gastrotropin | / | 0.446 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 1pl8 | NAD | Sorbitol dehydrogenase | 1.1.1.14 | 0.446 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.446 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.446 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 1xqc | AEJ | Estrogen receptor | / | 0.446 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2bil | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.446 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.446 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3glm | COO | Glutaconyl-CoA decarboxylase alpha subunit | / | 0.446 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3i6r | J5Z | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.446 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.446 | |
| 3l9n | L9N | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.446 | |
| 3p2e | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.446 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.446 | |
| 3reo | EUG | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.446 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.446 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.446 | |
| 4lsl | 1YQ | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.446 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.446 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.446 | |
| 1cde | DZF | Phosphoribosylglycinamide formyltransferase | / | 0.445 | |
| 1eet | BFU | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.445 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.445 | |
| 1vru | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.445 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.445 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.445 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 2lbv | EB4 | Extracellular fatty acid-binding protein | / | 0.445 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.445 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3dmj | GWE | Pol protein | / | 0.445 | |
| 3gi3 | B10 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.445 | |
| 4c2z | MYA | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.445 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.445 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.445 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.444 | |
| 1sqv | UHD | Cytochrome b | / | 0.444 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.444 | |
| 1xp6 | AIU | Estrogen receptor | / | 0.444 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.444 | |
| 2bxe | 1FL | Serum albumin | / | 0.444 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.444 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.444 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.444 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2ynf | WHU | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.444 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3eem | 53V | Uncharacterized protein | / | 0.444 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.444 | |
| 3iqe | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.444 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.444 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.444 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.444 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.444 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.444 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.444 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.444 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4hqv | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.444 | |
| 4jaq | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.444 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.444 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 5c8d | 5AD | Probable transcriptional regulator | / | 0.444 | |
| 5es7 | FON | Linear gramicidin synthase subunit A | / | 0.444 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1kk4 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.443 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.443 | |
| 1tkz | H16 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.443 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.443 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2xwe | AMF | Glucosylceramidase | 3.2.1.45 | 0.443 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3g8e | IS1 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.443 | |
| 3lam | KRP | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.443 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.443 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 3uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.443 | |
| 3ufn | ROC | Gag-Pol polyprotein | / | 0.443 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.443 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.443 | |
| 3zlm | ANP | Adenosine monophosphate-protein transferase NmFic | 2.7.7.n1 | 0.443 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.443 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.443 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.443 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.443 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.443 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.443 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.443 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.442 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.442 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.442 | |
| 1pt8 | ACO | Formyl-CoA:oxalate CoA-transferase | / | 0.442 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.442 | |
| 1s60 | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.442 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1z1f | STL | Resveratrol synthase | / | 0.442 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2ejz | SAH | Diphthine synthase | / | 0.442 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.442 | |
| 2pir | DHT | Androgen receptor | / | 0.442 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.442 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.442 | |
| 2y3s | TIR | TamL | / | 0.442 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.442 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.442 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.442 | |
| 3a7d | FBN | Catechol O-methyltransferase | 2.1.1.6 | 0.442 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.442 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3dok | GWJ | Pol protein | / | 0.442 | |
| 3huc | G97 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.442 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.442 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.442 | |
| 3ubd | SL0 | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.442 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.442 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.442 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.442 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4k2x | FAD | Polyketide oxygenase/hydroxylase | / | 0.442 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.442 | |
| 5ii2 | LU2 | Protein polybromo-1 | / | 0.442 | |
| 1it7 | GUN | tRNA-guanine(15) transglycosylase | 2.4.2.48 | 0.441 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.441 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.441 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.441 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.441 | |
| 1u2d | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.441 | |
| 1zc4 | GNP | Ras-related protein Ral-A | / | 0.441 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.441 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.441 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.441 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2ol4 | JPN | Enoyl-ACP reductase | / | 0.441 | |
| 2qjy | SMA | Cytochrome b | / | 0.441 | |
| 2y03 | Y01 | Beta-1 adrenergic receptor | / | 0.441 | |
| 3cgy | RDC | Virulence sensor histidine kinase PhoQ | 2.7.13.3 | 0.441 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.441 | |
| 3kdt | 7HA | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 3klj | FAD | NADH-rubredoxin oxidoreductase | 1.18.1.1 | 0.441 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3n8w | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.441 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.441 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3uic | 09T | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.441 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3zuy | TCH | Transporter | / | 0.441 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4b8u | IBK | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase | 4.2.1.59 | 0.441 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.441 | |
| 4ez5 | 0RS | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.441 | |
| 4ie0 | PD2 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.441 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.441 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.441 | |
| 4jap | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.441 | |
| 4lvb | 20N | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.441 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 4oth | DRN | Serine/threonine-protein kinase N1 | / | 0.441 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.441 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4zas | TYD | CalS13 | / | 0.441 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.441 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.441 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1chw | HXC | Chalcone synthase 2 | 2.3.1.74 | 0.440 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.440 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.440 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.440 | |
| 1l0l | FMX | Cytochrome b | / | 0.440 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1q4g | BFL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.440 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.440 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1ybg | TAV | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.440 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.440 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.440 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.440 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.440 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.440 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3ict | COA | Coenzyme A disulfide reductase | / | 0.440 | |
| 3ntd | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.440 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.440 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3wy0 | COA | Uncharacterized protein | / | 0.440 | |
| 3zux | TCH | Transporter | / | 0.440 | |
| 4b8z | GDP | GDP-L-fucose synthase | 1.1.1.271 | 0.440 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4ceo | G0T | Integrase | / | 0.440 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.440 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.440 | |
| 4f4p | 0SB | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.440 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 4h4s | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.440 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.440 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.440 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4ok1 | 198 | Androgen receptor | / | 0.440 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.440 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.440 | |
| 5jad | FB2 | Platelet-activating factor acetylhydrolase | 3.1.1.47 | 0.440 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.440 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.440 |