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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1fecFADTrypanothione reductase1.8.1.12

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1fecFADTrypanothione reductase1.8.1.121.000
1tytFADTrypanothione reductase1.8.1.120.678
2jk6FADTrypanothione reductase/0.609
4dnaFADProbable glutathione reductase/0.601
2hqmFADGlutathione reductase1.8.1.70.593
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.585
1gxfFADTrypanothione reductase1.8.1.120.584
1grhFADGlutathione reductase, mitochondrial1.8.1.70.575
4la1FADThioredoxin glutathione reductase/0.568
1bzlFADTrypanothione reductase1.8.1.120.552
4j56FADThioredoxin reductase 21.8.1.90.548
2wbaFADTrypanothione reductase1.8.1.120.545
1febFADTrypanothione reductase1.8.1.120.538
4nevFADTrypanothione reductase/0.534
3grsFADGlutathione reductase, mitochondrial1.8.1.70.529
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.495
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.484
1dncFADGlutathione reductase, mitochondrial1.8.1.70.482
4j57FADThioredoxin reductase 21.8.1.90.470
2tprFADTrypanothione reductase1.8.1.120.467
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.463
2x8gFADThioredoxin glutathione reductase/0.452
2eq6FADDihydrolipoyl dehydrogenase/0.447
4eqwFADCoenzyme A disulfide reductase/0.447
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.446
2eq9FADDihydrolipoyl dehydrogenase/0.446
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.445