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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1f28F89Thymidylate synthase2.1.1.45

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1f28F89Thymidylate synthase2.1.1.451.000
1synF89Thymidylate synthase/0.551
1tsdF89Thymidylate synthase/0.522
1ju6LYAThymidylate synthase2.1.1.450.510
1jujLYAThymidylate synthase2.1.1.450.510
1nceCB3Thymidylate synthase/0.483
2vf0F89Thymidylate synthase/0.483
1dnaCB3Thymidylate synthase/0.473
1jtqLY3Thymidylate synthase/0.470
1tlcF89Thymidylate synthase/0.468
1kzjCB3Thymidylate synthase/0.458
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.454
2ftoCB3Thymidylate synthase/0.454
1f4fTP3Thymidylate synthase/0.451
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
4knzCB3Thymidylate synthase/0.448
3bgxMEFThymidylate synthase/0.446
4fogC2FThymidylate synthase ThyA/0.445
1kceCB3Thymidylate synthase/0.444
4foxD16Thymidylate synthase ThyA/0.444
1jutLYDThymidylate synthase/0.442
3bhlTHGThymidylate synthase/0.441