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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1esvLARActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1esvLARActin, alpha skeletal muscle/1.000
4b1uLABActin, alpha skeletal muscle/0.552
1rdwLARActin, alpha skeletal muscle/0.534
3buzLARActin, alpha skeletal muscle/0.524
1sqkLARActin, alpha skeletal muscle/0.518
4pkhADPActin, alpha skeletal muscle/0.514
1c0fATPMajor actin/0.497
4k42ADPActin, alpha skeletal muscle/0.497
2q0uLABActin, alpha skeletal muscle/0.496
3sjhLARActin, alpha skeletal muscle/0.474
4h03LARActin, alpha skeletal muscle/0.473
3chwATPMajor actin/0.470
4h0yLARActin, alpha skeletal muscle/0.467
3qw4U5POrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative/0.458
1ijjLARActin, alpha skeletal muscle/0.455
4fzvSAM5-methylcytosine rRNA methyltransferase NSUN42.1.10.455
1nmdATPMajor actin/0.453
4m63ATPActin-5C/0.451
2v51LABActin, alpha skeletal muscle/0.449
2v51ATPActin, alpha skeletal muscle/0.445
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
1rfqLARActin, alpha skeletal muscle/0.443
4b1vLABActin, alpha skeletal muscle/0.440