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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1eqyATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1eqyATPActin, alpha skeletal muscle/1.000
3mn7ATPActin-5C/0.598
1s22ATPActin, alpha skeletal muscle/0.588
3tu5ATPActin, alpha skeletal muscle/0.586
3el2ATPActin-5C/0.583
4k42ADPActin, alpha skeletal muscle/0.577
4pkgATPActin, alpha skeletal muscle/0.557
2q36ATPActin, alpha skeletal muscle/0.552
4k43ADPActin, alpha skeletal muscle/0.551
1qz5ATPActin, alpha skeletal muscle/0.549
4k41ATPActin, alpha skeletal muscle/0.546
4pl8ATPActin, alpha skeletal muscle/0.544
4cbxATPActin-2/0.542
1rgiATPActin, alpha skeletal muscle/0.538
1t44ATPActin, alpha skeletal muscle/0.534
3eksATPActin-5C/0.533
4ci6ATPActin/0.532
4jhdANPActin-5C/0.532
3dawATPActin, alpha skeletal muscle/0.531
2oanATPActin, cytoplasmic 1/0.520
3u9dATPActin, alpha skeletal muscle/0.514
1mduATPActin, alpha skeletal muscle/0.513
1yxqATPActin, alpha skeletal muscle/0.506
1dejATPMajor actin/0.503
2q97ATPActin, alpha skeletal muscle/0.500
2p9kATPActin-related protein 2/0.495