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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1eh4IC1Casein kinase I homolog 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1eh4IC1Casein kinase I homolog 12.7.11.11.000
3uyt0CKCasein kinase I isoform delta2.7.11.10.532
4kbk1QGCasein kinase I isoform delta2.7.11.10.532
3hmm855TGF-beta receptor type-12.7.11.300.518
4g160VMCasein kinase I isoform gamma-32.7.11.10.507
1vjy460TGF-beta receptor type-12.7.11.300.506
3zh8C58Protein kinase C iota type2.7.11.130.506
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.505
3sheI85MAP kinase-activated protein kinase 32.7.11.10.503
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.501
1g5sI17Cyclin-dependent kinase 22.7.11.220.498
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.498
3gubGUBDeath-associated protein kinase 12.7.11.10.491
1xjdSTUProtein kinase C theta type2.7.11.130.490
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.490
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.489
2wotZZGTGF-beta receptor type-12.7.11.300.487
1py5PY1TGF-beta receptor type-12.7.11.300.486
1u4dDBQActivated CDC42 kinase 1/0.485
2wouZZFTGF-beta receptor type-12.7.11.300.483
2x1nX1NCyclin-dependent kinase 22.7.11.220.483
3gxlQIGTGF-beta receptor type-12.7.11.300.482
3w33W19Epidermal growth factor receptor2.7.10.10.482
1h1s4SPCyclin-dependent kinase 22.7.11.220.481
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.481
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.481
4g170VNCasein kinase I isoform gamma-32.7.11.10.480
2b52D42Cyclin-dependent kinase 22.7.11.220.479
2csnCKICasein kinase I homolog 12.7.11.10.479
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.479
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.479
1aq1STUCyclin-dependent kinase 22.7.11.220.478
4c02TAKActivin receptor type-12.7.11.300.478
2izrBRKCasein kinase I isoform gamma-32.7.11.10.477
3lfqA28Cyclin-dependent kinase 22.7.11.220.477
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.476
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.476
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.476
1oguST8Cyclin-dependent kinase 22.7.11.220.475
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.475
3mtfA3FActivin receptor type-12.7.11.300.474
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.473
1csnATPCasein kinase I homolog 12.7.11.10.472
1m2pHNACasein kinase II subunit alpha2.7.11.10.471
2btrU73Cyclin-dependent kinase 22.7.11.220.471
3be9P04Casein kinase II subunit alpha2.7.11.10.471
1om1IQACasein kinase II subunit alpha2.7.11.10.470
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.470
3r83Z14Cyclin-dependent kinase 22.7.11.220.470
4qmzB49Serine/threonine-protein kinase 242.7.11.10.469
2iw94SPCyclin-dependent kinase 22.7.11.220.467
2pvmP29Casein kinase II subunit alpha2.7.11.10.467
3rni21ZCyclin-dependent kinase 22.7.11.220.467
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.467
1unlRRCCyclin-dependent-like kinase 52.7.11.10.466
2izuP01Casein kinase I isoform gamma-32.7.11.10.466
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.466
4hge15VTyrosine-protein kinase JAK2/0.466
4hgs15GCasein kinase I isoform gamma-32.7.11.10.466
4qnaX11Serine/threonine-protein kinase 242.7.11.10.466
2pvnP63Casein kinase II subunit alpha2.7.11.10.465
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.464
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.464
2pvhP19Casein kinase II subunit alpha2.7.11.10.464
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.464
4bcoT6QCyclin-dependent kinase 22.7.11.220.464
4fkv61KCyclin-dependent kinase 22.7.11.220.464
4hvi19STyrosine-protein kinase JAK32.7.10.20.464
2xa4AZ5Tyrosine-protein kinase JAK2/0.463
4dgnLU2Casein kinase II subunit alpha2.7.11.10.463
1gih1PUCyclin-dependent kinase 22.7.11.220.462
2c475IDCasein kinase I isoform gamma-2/0.462
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4yuqKS1Calmodulin-like domain protein kinase/0.462
1fvv107Cyclin-dependent kinase 22.7.11.220.461
4ek816KCyclin-dependent kinase 22.7.11.220.461
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.460
4fkt48KCyclin-dependent kinase 22.7.11.220.460
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
1oirHDYCyclin-dependent kinase 22.7.11.220.459
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.459
3uzp0CKCasein kinase I isoform delta2.7.11.10.459
1m2rMNYCasein kinase II subunit alpha2.7.11.10.458
4jqeANPCasein kinase II subunit alpha2.7.11.10.458
4qmpDKISerine/threonine-protein kinase 242.7.11.10.458
1oitHDTCyclin-dependent kinase 22.7.11.220.457
2b53D23Cyclin-dependent kinase 22.7.11.220.457
2h96893Mitogen-activated protein kinase 82.7.11.240.457
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.457
3lfnA27Cyclin-dependent kinase 22.7.11.220.457
4aacAAVMitogen-activated protein kinase 14/0.457
4ez50RSCyclin-dependent kinase 62.7.11.220.457
3hl7I47Mitogen-activated protein kinase 14/0.456
3nynSGVG protein-coupled receptor kinase 62.7.11.160.456
4bgg844Activin receptor type-12.7.11.300.456
3iok1P6Tyrosine-protein kinase JAK2/0.455
4hvh19RTyrosine-protein kinase JAK32.7.10.20.455
4y95746Tyrosine-protein kinase/0.455
2xikJ60Serine/threonine-protein kinase 252.7.11.10.454
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.454
1di8DTQCyclin-dependent kinase 22.7.11.220.453
1gii1PUCyclin-dependent kinase 22.7.11.220.453
2b7aIZATyrosine-protein kinase JAK2/0.453
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.453
2izt23DCasein kinase I isoform gamma-32.7.11.10.453
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.453
4fkg4CKCyclin-dependent kinase 22.7.11.220.453
1pmn984Mitogen-activated protein kinase 102.7.11.240.452
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.452
2pvlP55Casein kinase II subunit alpha2.7.11.10.452
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.452
3q43D66M1 family aminopeptidase3.4.110.452
3w32W32Epidermal growth factor receptor2.7.10.10.452
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.452
4btjADPTau-tubulin kinase 12.7.11.10.452
4c61LMMTyrosine-protein kinase JAK2/0.452
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.451
2vv9IM9Cyclin-dependent kinase 22.7.11.220.451
3rak03ZCyclin-dependent kinase 22.7.11.220.451
3s1h56ZCyclin-dependent kinase 22.7.11.220.451
3s2pPMUCyclin-dependent kinase 22.7.11.220.451
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.451
5cnnANPEpidermal growth factor receptor2.7.10.10.451
2btsU32Cyclin-dependent kinase 22.7.11.220.450
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.450
3r8lZ30Cyclin-dependent kinase 22.7.11.220.450
4ek610KCyclin-dependent kinase 22.7.11.220.450
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.450
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
1ke6LS2Cyclin-dependent kinase 22.7.11.220.449
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.449
2a4lRRCCyclin-dependent kinase 22.7.11.220.449
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2itpAEEEpidermal growth factor receptor2.7.10.10.449
3hllI45Mitogen-activated protein kinase 14/0.449
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.449
4bgh3I6Cyclin-dependent kinase 22.7.11.220.449
4dymIYZActivin receptor type-12.7.11.300.449
4f081RSTyrosine-protein kinase JAK2/0.449
5e8xSTUTGF-beta receptor type-12.7.11.300.449
1dawANPCasein kinase II subunit alpha2.7.11.10.448
2iw84SPCyclin-dependent kinase 22.7.11.220.448
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.448
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.448
3vs3VSETyrosine-protein kinase HCK2.7.10.20.448
3w2sW2REpidermal growth factor receptor2.7.10.10.448
4anmWULCasein kinase II subunit alpha2.7.11.10.448
4e4m0NHTyrosine-protein kinase JAK2/0.448
4eon1ROCyclin-dependent kinase 22.7.11.220.448
2c6kDT2Cyclin-dependent kinase 22.7.11.220.447
2in6839Wee1-like protein kinase2.7.10.20.447
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.447
3pj8404Cyclin-dependent kinase 22.7.11.220.447
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.447
4riyADPEpidermal growth factor receptor2.7.10.10.447
1ykr628Cyclin-dependent kinase 22.7.11.220.446
2c6o4SPCyclin-dependent kinase 22.7.11.220.446
3gu83GUDeath-associated protein kinase 12.7.11.10.446
5cnoANPEpidermal growth factor receptor2.7.10.10.446
1r78FMDCyclin-dependent kinase 22.7.11.220.445
1w0xOLOCyclin-dependent kinase 22.7.11.220.445
2j0m4STFocal adhesion kinase 12.7.10.20.445
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.445
3qt62P0Mevalonate diphosphate decarboxylase/0.445
4dgo0JWCasein kinase II subunit alpha2.7.11.10.445
4wboANWRhodopsin kinase/0.445
2a0cCK9Cyclin-dependent kinase 22.7.11.220.444
3cgfJNFMitogen-activated protein kinase 102.7.11.240.444
3ezrEZRCyclin-dependent kinase 22.7.11.220.444
3rjc06ZCyclin-dependent kinase 22.7.11.220.444
4aa4QC0Mitogen-activated protein kinase 14/0.444
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.444
4ewhT77Activated CDC42 kinase 1/0.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.444
2izsBRQCasein kinase I isoform gamma-32.7.11.10.443
3qu0X40Cyclin-dependent kinase 22.7.11.220.443
4btjATPTau-tubulin kinase 12.7.11.10.443
4btmF8ETau-tubulin kinase 12.7.11.10.443
4fki09KCyclin-dependent kinase 22.7.11.220.443
5e8ySTUTGF-beta receptor type-22.7.11.300.443
1pxoCK7Cyclin-dependent kinase 22.7.11.220.442
1vyzN5BCyclin-dependent kinase 22.7.11.220.442
2eufLQQCyclin-dependent kinase 62.7.11.220.442
2uzbC75Cyclin-dependent kinase 22.7.11.220.442
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.442
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.442
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.442
3sqq99ZCyclin-dependent kinase 22.7.11.220.442
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
1pxmCK5Cyclin-dependent kinase 22.7.11.220.441
2r3jSCJCyclin-dependent kinase 22.7.11.220.441
2r3lSCWCyclin-dependent kinase 22.7.11.220.441
2uznC96Cyclin-dependent kinase 22.7.11.220.441
2w17I19Cyclin-dependent kinase 22.7.11.220.441
3hx4ANPCalmodulin-domain protein kinase 1/0.441
3nwq2NCGag-Pol polyprotein3.4.23.160.441
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.441
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.440
1dayGNPCasein kinase II subunit alpha2.7.11.10.440
1gij2PUCyclin-dependent kinase 22.7.11.220.440
1oi9N20Cyclin-dependent kinase 22.7.11.220.440
1oiyN41Cyclin-dependent kinase 22.7.11.220.440
3ggfGVDSerine/threonine-protein kinase 26/0.440
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3rk708ZCyclin-dependent kinase 22.7.11.220.440
4bcpT3CCyclin-dependent kinase 22.7.11.220.440
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.440
4hgt15GCasein kinase I isoform delta2.7.11.10.440
4ix6ADPUncharacterized protein/0.440