sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 1.000 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.832 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.745 | |
| 1gr1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.737 | |
| 1ogj | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.725 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.693 | |
| 1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.679 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.676 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.653 | |
| 4af6 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.651 | |
| 1e63 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.643 | |
| 1w35 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.640 | |
| 3zbt | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.632 | |
| 1fnc | FDA | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.629 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.628 | |
| 1fnd | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.617 | |
| 1gaw | FAD | Ferredoxin | / | 0.614 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.611 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.610 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.607 | |
| 1qgz | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.603 | |
| 2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.602 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.598 | |
| 1qh0 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.596 | |
| 1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.596 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.594 | |
| 4bpr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.594 | |
| 1gaq | FAD | Ferredoxin | / | 0.593 | |
| 1bx0 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.589 | |
| 1fnb | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.589 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.587 | |
| 1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.580 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.576 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.570 | |
| 3w5u | FAD | Ferredoxin | / | 0.552 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.538 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.537 | |
| 3jqr | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.528 | |
| 1b2r | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.527 | |
| 1ja1 | FAD | NADPH--cytochrome P450 reductase | / | 0.524 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.515 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.507 | |
| 4uaj | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.504 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.502 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.499 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.499 | |
| 3qfs | FAD | NADPH--cytochrome P450 reductase | / | 0.498 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.497 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.496 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.493 | |
| 4yao | FAD | NADPH--cytochrome P450 reductase | / | 0.492 | |
| 2rc5 | FAD | Ferredoxin--NADP reductase | / | 0.491 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.491 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.487 | |
| 3qfc | FAD | NADPH--cytochrome P450 reductase | / | 0.487 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.486 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.484 | |
| 3ntr | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.483 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.483 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.482 | |
| 3bus | SAH | Demethylrebeccamycin-D-glucose O-methyltransferase | / | 0.481 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.481 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.480 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.479 | |
| 2ejz | SAH | Diphthine synthase | / | 0.479 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.478 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.478 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.477 | |
| 2xnc | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.477 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.477 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.476 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.475 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.475 | |
| 4bz8 | J38 | Histone deacetylase | / | 0.475 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.474 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.474 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.474 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.474 | |
| 2qe2 | 452 | Polyprotein | / | 0.473 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.473 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.473 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.472 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.472 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.471 | |
| 2ptf | FMN | Uncharacterized protein MTH_863 | / | 0.471 | |
| 1amo | FAD | NADPH--cytochrome P450 reductase | / | 0.470 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.470 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.470 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.470 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.469 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.468 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.468 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.468 | |
| 4n4w | SNT | Smoothened homolog | / | 0.468 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.467 | |
| 3c1o | NAP | Eugenol synthase | / | 0.467 | |
| 2gms | P0P | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.466 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4fl0 | PLP | Aminotransferase ALD1, chloroplastic | 2.6.1 | 0.466 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.465 | |
| 3nt5 | NAI | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.465 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.464 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.464 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.464 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.464 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.464 | |
| 4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.464 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.462 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.462 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 5d7o | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.462 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.461 | |
| 1vce | SAH | Diphthine synthase | / | 0.461 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.461 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.461 | |
| 4j7h | TRH | PCZA361.3 | / | 0.461 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.460 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.460 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.460 | |
| 2bpo | FAD | NADPH--cytochrome P450 reductase | / | 0.459 | |
| 2dsg | SAH | Diphthine synthase | / | 0.459 | |
| 3ihz | FK5 | Peptidylprolyl isomerase | / | 0.459 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.459 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.459 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.459 | |
| 1ah4 | NAP | Aldose reductase | 1.1.1.21 | 0.458 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.458 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.458 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.457 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.457 | |
| 3reo | EUG | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.457 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.456 | |
| 1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.456 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.455 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.455 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.455 | |
| 2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.455 | |
| 3nt2 | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.455 | |
| 4mzu | TYD | WxcM-like protein | / | 0.455 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.454 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.454 | |
| 2r6h | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.454 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.454 | |
| 3bnk | FMN | Flavoredoxin | / | 0.454 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.454 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.454 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.454 | |
| 3tza | TZG | Glutamate receptor 2 | / | 0.454 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.454 | |
| 4b67 | FAD | L-ornithine N(5)-monooxygenase | / | 0.454 | |
| 4y9u | FAD | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.453 | |
| 1qtq | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.453 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.453 | |
| 1ye4 | NAD | NAD(P)H-dependent D-xylose reductase | 1.1.1.307 | 0.453 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4isu | IKM | Glutamate receptor 2 | / | 0.453 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.452 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.452 | |
| 2emu | SAH | Diphthine synthase | / | 0.452 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.452 | |
| 2wea | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.452 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.452 | |
| 3ox2 | 79X | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.452 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4j0y | 1H6 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.452 | |
| 1fdr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.451 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.451 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.451 | |
| 2npf | MOU | Elongation factor 2 | / | 0.451 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.451 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.451 | |
| 2xda | JPS | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.451 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.450 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.450 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.450 | |
| 2e16 | SAH | Diphthine synthase | / | 0.450 | |
| 3e6e | DCS | Alanine racemase | / | 0.450 | |
| 3e78 | TPP | High affinity transport system protein p37 | / | 0.450 | |
| 3eku | CY9 | Actin-5C | / | 0.450 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 5f59 | SAH | Histone-lysine N-methyltransferase 2C | 2.1.1.43 | 0.450 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 1n3s | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.449 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 2ejk | SAH | Diphthine synthase | / | 0.449 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.449 | |
| 2gmu | PDG | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.449 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.449 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.449 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.449 | |
| 5je4 | SAH | Methyl transferase | / | 0.449 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1tll | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 1z41 | FMN | NADPH dehydrogenase | / | 0.448 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.448 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2wzw | FMN | Nitroreductase NfnB | / | 0.448 | |
| 2y01 | Y00 | Beta-1 adrenergic receptor | / | 0.448 | |
| 2zts | ADP | Uncharacterized protein | / | 0.448 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.448 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.448 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.448 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.448 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.448 | |
| 4xmx | BES | Aminopeptidase N | 3.4.11.2 | 0.448 | |
| 1c9w | NAP | Aldose reductase-related protein 2 | / | 0.447 | |
| 1cqx | FAD | Flavohemoprotein | / | 0.447 | |
| 1e79 | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.447 | |
| 1e79 | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1ozq | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 1zsk | 421 | Coagulation factor XI | 3.4.21.27 | 0.447 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.447 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.447 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.447 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.447 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.447 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.447 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.447 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 4pl0 | ANP | Microcin-J25 export ATP-binding/permease protein McjD | / | 0.447 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.447 | |
| 5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.447 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.446 | |
| 1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.446 | |
| 1u2r | SO1 | Elongation factor 2 | / | 0.446 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.446 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.446 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.446 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.446 | |
| 2p6d | SAH | Diphthine synthase | / | 0.446 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.446 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3er9 | 3AT | Poly(A) polymerase catalytic subunit | 2.7.7.19 | 0.446 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3lq4 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.446 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.446 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.446 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.446 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.446 | |
| 4phl | PIL | Phosphodiesterase | / | 0.446 | |
| 5fx2 | FMN | Flavodoxin | / | 0.446 | |
| 1a4l | DCF | Adenosine deaminase | 3.5.4.4 | 0.445 | |
| 1po7 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
| 1vhz | APR | ADP compounds hydrolase NudE | 3.6.1 | 0.445 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.445 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.445 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.445 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3kmy | D8Y | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.445 | |
| 3owx | XRA | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.445 | |
| 4f3g | KAI | Glutamate receptor 3 | / | 0.445 | |
| 4h03 | NAD | Iota toxin component Ia | / | 0.445 | |
| 4wct | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.445 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1til | ATP | Anti-sigma F factor | / | 0.444 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.444 | |
| 2vqj | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.444 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.444 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 3nhj | A2Z | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4bek | XK0 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4e32 | DWN | Methyltransferase | / | 0.444 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.444 | |
| 4k2x | FAD | Polyketide oxygenase/hydroxylase | / | 0.444 | |
| 4l7h | 1W1 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.444 | |
| 4odo | FK5 | Peptidyl-prolyl cis-trans isomerase | / | 0.444 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.444 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.444 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.443 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.443 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.443 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.443 | |
| 2cts | COA | Citrate synthase, mitochondrial | 2.3.3.1 | 0.443 | |
| 2eeq | SAH | Diphthine synthase | / | 0.443 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.443 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.443 | |
| 2wzg | UPG | Uncharacterized protein | / | 0.443 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.443 | |
| 3uaz | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.443 | |
| 4ac0 | MIY | Tetracycline repressor protein class B from transposon Tn10 | / | 0.443 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 4j7g | TRH | PCZA361.3 | / | 0.443 | |
| 4js1 | CTN | Beta-galactoside alpha-2,6-sialyltransferase 1 | 2.4.99.1 | 0.443 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.443 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.443 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.442 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.442 | |
| 2aqb | TL6 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.442 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.442 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.442 | |
| 2tpl | HPP | Tyrosine phenol-lyase | 4.1.99.2 | 0.442 | |
| 2wat | COA | Fatty acid synthase subunit alpha | 2.3.1.86 | 0.442 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.442 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3ntq | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.442 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.442 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4bfd | 8T3 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4tla | ADP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.442 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.442 | |
| 5dp2 | NAP | CurF | / | 0.442 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1k8z | IAG | Tryptophan synthase alpha chain | / | 0.441 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.441 | |
| 2owv | SAH | Diphthine synthase | / | 0.441 | |
| 2po3 | T4K | 4-dehydrase | / | 0.441 | |
| 2r5n | TPP | Transketolase 1 | / | 0.441 | |
| 2re8 | GSU | Glutamine--tRNA ligase | 6.1.1.18 | 0.441 | |
| 2zrv | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3eks | CY9 | Actin-5C | / | 0.441 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.441 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.441 | |
| 4a3u | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.441 | |
| 4k1x | FAD | NADPH:ferredoxin reductase | / | 0.441 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.441 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.441 | |
| 1hzz | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.440 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.440 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.440 | |
| 2wp9 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.440 | |
| 2wp9 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.440 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3cso | XNI | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.440 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.440 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.440 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.440 |