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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1drfFOLDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1drfFOLDihydrofolate reductase1.5.1.31.000
1pd9CO4Dihydrofolate reductase1.5.1.30.556
1dhfFOLDihydrofolate reductase1.5.1.30.550
3n0hTOPDihydrofolate reductase1.5.1.30.547
2dhfDZFDihydrofolate reductase1.5.1.30.544
1s3uTQDDihydrofolate reductase1.5.1.30.525
1mvsDTMDihydrofolate reductase1.5.1.30.520
2w3bNDPDihydrofolate reductase1.5.1.30.511
3s3vTOPDihydrofolate reductase1.5.1.30.510
3s7a684Dihydrofolate reductase1.5.1.30.507
3oafOAGDihydrofolate reductase1.5.1.30.503
4g95OAGDihydrofolate reductase1.5.1.30.495
3d84NDPDihydrofolate reductase1.5.1.30.473
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.472
1mvtDTMDihydrofolate reductase1.5.1.30.466
1dr3TAPDihydrofolate reductase1.5.1.30.465
3nxxNDPDihydrofolate reductase1.5.1.30.455
1diuBDMDihydrofolate reductase1.5.1.30.446
1s3vTQDDihydrofolate reductase1.5.1.30.445
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3eigMTXDihydrofolate reductase1.5.1.30.445
4elb34SDihydrofolate reductase/0.445
1u71MXADihydrofolate reductase1.5.1.30.443
1dr5NAPDihydrofolate reductase1.5.1.30.441
4elb34RDihydrofolate reductase/0.440
4elf35IDihydrofolate reductase/0.440