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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dreMTXDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
1dreMTXDihydrofolate reductase1.5.1.31.000
7dfrFOLDihydrofolate reductase1.5.1.30.680
1rh3MTXDihydrofolate reductase1.5.1.30.639
3ql3FOLDihydrofolate reductase1.5.1.30.621
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.600
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.593
4nx6FOLDihydrofolate reductase1.5.1.30.591
1rx2FOLDihydrofolate reductase1.5.1.30.590
1aoeGW3Dihydrofolate reductase1.5.1.30.589
3dauMTXDihydrofolate reductase1.5.1.30.589
1ra2FOLDihydrofolate reductase1.5.1.30.588
2fzhDH1Dihydrofolate reductase1.5.1.30.588
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.583
3tq8TOPDihydrofolate reductase/0.583
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.581
4x5fFOLDihydrofolate reductase1.5.1.30.581
1dyrTOPDihydrofolate reductase1.5.1.30.579
3qlrQLRDihydrofolate reductase1.5.1.30.579
4fhbFOLDihydrofolate reductase1.5.1.30.577
4x5gFOLDihydrofolate reductase1.5.1.30.577
2zzaFOLDihydrofolate reductase/0.576
3dfrMTXDihydrofolate reductase1.5.1.30.574
1klkPMDDihydrofolate reductase1.5.1.30.573
3qlxQLRUncharacterized protein/0.573
3tq9MTXDihydrofolate reductase/0.573
4g8zTOPDihydrofolate reductase1.5.1.30.573
1rx3MTXDihydrofolate reductase1.5.1.30.572
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.571
3qls55VDihydrofolate reductase1.5.1.30.570
3qly55VUncharacterized protein/0.570
1m78CLZDihydrofolate reductase1.5.1.30.565
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.565
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.564
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.563
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.562
1cd2FOLDihydrofolate reductase1.5.1.30.560
4nx7FOLDihydrofolate reductase1.5.1.30.560
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.558
4ixgIXGDihydrofolate reductase1.5.1.30.557
1dg5TOPDihydrofolate reductase1.5.1.30.553
3fywXCFDihydrofolate reductase1.5.1.30.553
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.552
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.550
2w3vTOPDihydrofolate reductase/0.549
3srsM23Dihydrofolate reductase1.5.1.30.547
1bozPRDDihydrofolate reductase1.5.1.30.546
3sai9DRDihydrofolate reductase/0.546
1ia1TQ3Dihydrofolate reductase1.5.1.30.545
1ludTRRDihydrofolate reductase1.5.1.30.544
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.544
3sqyQ11Dihydrofolate reductase1.5.1.30.544
1dajMOTDihydrofolate reductase1.5.1.30.543
2w3wVG9Dihydrofolate reductase/0.543
3eek53SUncharacterized protein/0.541
3sr5Q12Dihydrofolate reductase1.5.1.30.541
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.540
1vj3TABDihydrofolate reductase1.5.1.30.538
2fziDH3Dihydrofolate reductase1.5.1.30.538
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.538
4p68MTXDihydrofolate reductase/0.538
3freTOPDihydrofolate reductase1.5.1.30.537
3frfXCFDihydrofolate reductase1.5.1.30.537
2cd2FOLDihydrofolate reductase1.5.1.30.536
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.535
4h9753SDihydrofolate reductase1.5.1.30.535
3ia4MTXDihydrofolate reductase/0.532
1m7aMQUDihydrofolate reductase1.5.1.30.530
3sgy06WDihydrofolate reductase1.5.1.30.530
4m7vRARDihydrofolate reductase/0.530
3eem53VUncharacterized protein/0.528
4h9506UDihydrofolate reductase1.5.1.30.527
4h9814QUncharacterized protein/0.527
3cseN22Uncharacterized protein/0.524
3eej53RUncharacterized protein/0.524
3i8aN22Dihydrofolate reductase1.5.1.30.524
3fy8XCFDihydrofolate reductase1.5.1.30.523
4kjjFOLDihydrofolate reductase1.5.1.30.522
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.521
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.520
3fraI2HDihydrofolate reductase1.5.1.30.519
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.519
3oafOAGDihydrofolate reductase1.5.1.30.518
3rg9WRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.517
3sh25DRDihydrofolate reductase1.5.1.30.517
4m6l21VDihydrofolate reductase1.5.1.30.517
1ly3COGDihydrofolate reductase1.5.1.30.515
4ixeIXEDihydrofolate reductase1.5.1.30.515
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.512
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.510
3datMTXDihydrofolate reductase/0.510
3sa27DRDihydrofolate reductase/0.509
4p66MTXDihydrofolate reductase/0.509
3k47D09Dihydrofolate reductase1.5.1.30.508
3qlwN22Dihydrofolate reductase1.5.1.30.508
4hu1V13Carbonic anhydrase 134.2.1.10.508
4xe606UDihydrofolate reductase1.5.1.30.508
1rx8FOLDihydrofolate reductase1.5.1.30.507
3qlsNDPDihydrofolate reductase1.5.1.30.507
3jwm5WBDihydrofolate reductase/0.505
1df7MTXDihydrofolate reductase1.5.1.30.503
1e26GPBDihydrofolate reductase1.5.1.30.503
1rx1NAPDihydrofolate reductase1.5.1.30.503
3ddw055Glycogen phosphorylase, liver form2.4.1.10.503
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.503
4h9614QDihydrofolate reductase1.5.1.30.503
4qjcIXEDihydrofolate reductase1.5.1.30.503
1ai9NDPDihydrofolate reductase1.5.1.30.502
2w3aTOPDihydrofolate reductase1.5.1.30.502
3nxrD2DDihydrofolate reductase1.5.1.30.502
4ixfIXFDihydrofolate reductase1.5.1.30.502
2fzjDH3Dihydrofolate reductase1.5.1.30.501
3v1mHPK2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase3.7.1.80.501
4g95OAGDihydrofolate reductase1.5.1.30.501
1kmsLIHDihydrofolate reductase1.5.1.30.500
4ap1NAPSteroid monooxygenase/0.499
1ie9VDXVitamin D3 receptor/0.498
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.498
1b2lNDCAlcohol dehydrogenase1.1.1.10.497
5i2hAGIO-methyltransferase family 2/0.497
2w9hTOPDihydrofolate reductase1.5.1.30.496
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.495
1bzfTMQDihydrofolate reductase1.5.1.30.494
4m2xTMQDihydrofolate reductase1.5.1.30.494
3tqbFOLDihydrofolate reductase/0.493
3w0hW12Vitamin D3 receptor/0.491
1ddsMTXDihydrofolate reductase1.5.1.30.490
1s3yTQTDihydrofolate reductase1.5.1.30.490
1xj7DHTAndrogen receptor/0.490
5cccDDFDihydrofolate reductase1.5.1.30.490
2vaxCSCAcetyl-CoA--deacetylcephalosporin C acetyltransferase2.3.1.1750.489
3gyf51PDihydrofolate reductase1.5.1.30.489
3srqQ19Dihydrofolate reductase1.5.1.30.489
2h55DZ8Heat shock protein HSP 90-alpha/0.488
1dtpAPUDiphtheria toxin/0.487
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.487
2fszOHTEstrogen receptor beta/0.487
2oalFADFlavin-dependent tryptophan halogenase RebH1.14.19.90.487
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.487
3drcMTXDihydrofolate reductase1.5.1.30.487
3h3sH15Collagen type IV alpha-3-binding protein/0.486
2j9lATPH(+)/Cl(-) exchange transporter 5/0.485
1ia2TQ4Dihydrofolate reductase1.5.1.30.484
1xp9AIJEstrogen receptor/0.484
1zky689Estrogen receptor/0.484
3maaFKPAdenylate cyclase type 2/0.484
3maaFKPAdenylate cyclase type 5/0.484
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.484
1rb3MTXDihydrofolate reductase1.5.1.30.483
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.483
3fyvXCFDihydrofolate reductase1.5.1.30.483
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.483
1ddrMTXDihydrofolate reductase1.5.1.30.482
1tllFMNNitric oxide synthase, brain1.14.13.390.482
1upw444Oxysterols receptor LXR-beta/0.482
3uf6CODLmo1369 protein/0.482
2ociTYCValacyclovir hydrolase3.10.481
3eel53TUncharacterized protein/0.481
1dgfNDPCatalase1.11.1.60.480
1drhNAPDihydrofolate reductase1.5.1.30.480
1errRALEstrogen receptor/0.480
2c3oTPPPyruvate synthase/0.480
2dxdANPNucleoside diphosphate kinase2.7.4.60.480
2w6qOA5Biotin carboxylase6.3.4.140.480
3h3r14HCollagen type IV alpha-3-binding protein/0.480
3lnbCOAN-acetyltransferase family protein/0.480
3v4aPK1Androgen receptor/0.480
1osvCHCBile acid receptor/0.479
1rg7MTXDihydrofolate reductase1.5.1.30.479
2pdaTPPPyruvate synthase/0.479
4awo99BHeat shock protein HSP 90-alpha/0.479
4kak06UDihydrofolate reductase1.5.1.30.479
4rujVDXVitamin D3 receptor A/0.479
1diuBDMDihydrofolate reductase1.5.1.30.478
3l3rOAGDihydrofolate reductase1.5.1.30.478
3rl45GPMetallophosphoesterase MPPED23.10.478
3w0yDS4Vitamin D3 receptor/0.478
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.478
1rx8NAPDihydrofolate reductase1.5.1.30.477
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.477
3nxyD2HDihydrofolate reductase1.5.1.30.477
3qlrNDPDihydrofolate reductase1.5.1.30.477
4oal245Cytokinin dehydrogenase 4/0.477
1m78NDPDihydrofolate reductase1.5.1.30.476
1s3wTQTDihydrofolate reductase1.5.1.30.476
1uyhPU0Heat shock protein HSP 90-alpha/0.476
4a802ANMajor pollen allergen Bet v 1-A/0.476
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.476
1fbyREARetinoic acid receptor RXR-alpha/0.475
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.475
2hasC3OVitamin D3 receptor/0.475
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.475
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.475
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.475
4i8vBHFCytochrome P450 1A11.14.14.10.475
4j7xSASSepiapterin reductase1.1.1.1530.475
2rlcCHDCholoylglycine hydrolase3.5.1.240.474
2wi72KLHeat shock protein HSP 90-alpha/0.474
3itzP66Mitogen-activated protein kinase 14/0.474
4a8v2ANMajor pollen allergen Bet v 1-J/0.474
4j26ESTEstrogen receptor beta/0.474
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.473
1ohjCOPDihydrofolate reductase1.5.1.30.473
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.473
3och2MXDihydrofolate reductase1.5.1.30.473
4bvnP32Beta-1 adrenergic receptor/0.473
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
4rrhA3SProbable threonine--tRNA ligase 26.1.1.30.473
1bk0ACVIsopenicillin N synthase1.21.3.10.472
2dw4FADLysine-specific histone demethylase 1A10.472
3tqaNDPDihydrofolate reductase/0.472
5eccNAPDehydrofolate reductase type I/0.472
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.471
1rftPXMPyridoxal kinase2.7.1.350.471
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.471
2npxNADNADH peroxidase1.11.1.10.471
3nxxNDPDihydrofolate reductase1.5.1.30.471
3w0c6DSVitamin D3 receptor/0.471
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.471
3emlZMAAdenosine receptor A2a/0.471
2hb8MVDVitamin D3 receptor/0.470
2v58LZJBiotin carboxylase6.3.4.140.470
3a783EVVitamin D3 receptor/0.470
3eigMTXDihydrofolate reductase1.5.1.30.470
3nxvD2FDihydrofolate reductase1.5.1.30.470
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.470
3w0aDS5Vitamin D3 receptor/0.470
4okt198Androgen receptor/0.470
4okx198Androgen receptor/0.470
5jtbZMAAdenosine receptor A2a/0.470
1gwrESTEstrogen receptor/0.469
4gdaBTNStreptavidin/0.469
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.468
1ia3TQ5Dihydrofolate reductase1.5.1.30.468
2ocfESTEstrogen receptor/0.468
2zbaZBATrichothecene 3-O-acetyltransferase/0.468
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
3h4vDVPPteridine reductase 11.5.1.330.468
3ipkPMSSurface protein adhesin/0.468
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
4k6fNAPPutative Acetoacetyl-CoA reductase/0.468
1fw0KAIGlutamate receptor 2/0.467
1gky5GPGuanylate kinase2.7.4.80.467
1jlcFTCGag-Pol polyprotein2.7.7.490.467
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.467
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.467
3anlSYC1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.467
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.467
4kfj1R0Dihydrofolate reductase1.5.1.30.467
4qtuSAM18S rRNA (guanine(1575)-N(7))-methyltransferase/0.467
5cwa0GAAnthranilate synthase component 14.1.3.270.467
1draMTXDihydrofolate reductase1.5.1.30.466
1gpeFADGlucose oxidase1.1.3.40.466
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
1ppkIVVPenicillopepsin-13.4.23.200.466
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.466
2oc4IMHPurine nucleoside phosphorylase2.4.2.10.466
2z4jDHTAndrogen receptor/0.466
3akn11DFatty acid-binding protein, intestinal/0.466
3c14FOKAdenylate cyclase type 2/0.466
3c14FOKAdenylate cyclase type 5/0.466
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.466
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.466
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.466
3nxoD2BDihydrofolate reductase1.5.1.30.466
3nxtD2EDihydrofolate reductase1.5.1.30.466
3zs5SB2Mitogen-activated protein kinase 14/0.466
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.466
4iteTEYVitamin D3 receptor/0.466
4kd79DRDihydrofolate reductase1.5.1.30.466
4knnE1FCarbonic anhydrase 134.2.1.10.466
4mv8ACPBiotin carboxylase6.3.4.140.466
4yswNAIXanthine dehydrogenase/oxidase/0.466
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.465
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
2j62GSZO-GlcNAcase NagJ/0.465
2rtmIMIStreptavidin/0.465
3dhbC6LN-acyl homoserine lactonase AiiA3.1.1.810.465
3kpzZNEVitamin D3 receptor/0.465
4eiyZMAAdenosine receptor A2a/0.465
4m8hR4MRetinoic acid receptor RXR-alpha/0.465
5iqdGNPBifunctional AAC/APH2.3.10.465
1ia1NDPDihydrofolate reductase1.5.1.30.464
1o5gCR9Prothrombin3.4.21.50.464
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.464
1xpcAITEstrogen receptor/0.464
2r6jNDPEugenol synthase 11.1.1.3180.464
3cr0809Wee1-like protein kinase2.7.10.20.464
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.464
3h3t16HCollagen type IV alpha-3-binding protein/0.464
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.464
3l05SN0N-acetylornithine carbamoyltransferase2.1.3.90.464
3oapREARetinoic acid receptor RXR-alpha/0.464
4ruoBIVVitamin D3 receptor A/0.464
5im3DTPRibonucleoside-diphosphate reductase/0.464
1gj5130Prothrombin3.4.21.50.463
1jtqLY3Thymidylate synthase/0.463
2hb7O1CVitamin D3 receptor/0.463
2yjaESTEstrogen receptor/0.463
3ix4TX1Transcriptional activator protein LasR/0.463
3pre3REPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
3r8zZ63Cyclin-dependent kinase 22.7.11.220.463
3zkyWT4Isopenicillin N synthase1.21.3.10.463
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
4hy6FJ1Heat shock protein HSP 90-alpha/0.463
4ia1BIVVitamin D3 receptor A/0.463
4ivw1GJEstrogen receptor/0.463
4rraA3TProbable threonine--tRNA ligase 26.1.1.30.463
5dtoSAHGenome polyprotein/0.463
5k2aZMAAdenosine receptor A2a/0.463
1j3jNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.462
1pd9CO4Dihydrofolate reductase1.5.1.30.462
1qknRALEstrogen receptor beta/0.462
1rx02MCIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.462
1s3uTQDDihydrofolate reductase1.5.1.30.462
1tdrMTXDihydrofolate reductase1.5.1.30.462
2bxqIMNSerum albumin/0.462
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
2jfaRALEstrogen receptor/0.462
2qpyDHTAndrogen receptor/0.462
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.462
2rtnIMIStreptavidin/0.462
2w6pOA4Biotin carboxylase6.3.4.140.462
2z7gEH9Adenosine deaminase3.5.4.40.462
2zcePYLPyrrolysine--tRNA ligase/0.462
3ix8TX3Transcriptional activator protein LasR/0.462
3ollESTEstrogen receptor beta/0.462
3pm0BHFCytochrome P450 1B1/0.462
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
3sf6FDAGlutaryl-CoA dehydrogenase/0.462
3zeiAWHO-acetylserine sulfhydrylase/0.462
4frs0V6Beta-secretase 13.4.23.460.462
4k4j1O8Retinoic acid receptor RXR-alpha/0.462
5bukFADFADH2-dependent halogenase/0.462
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.461
1k749CRRetinoic acid receptor RXR-alpha/0.461
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.461
1srhMOBStreptavidin/0.461
2cig1DGDihydrofolate reductase1.5.1.30.461
2npfMOUElongation factor 2/0.461
2vbpVB1Isopenicillin N synthase1.21.3.10.461
3a8wATPProtein kinase C iota type2.7.11.130.461
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.461
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.461
3gcq1BUMitogen-activated protein kinase 14/0.461
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.461
4rrmA3TProbable threonine--tRNA ligase 26.1.1.30.461
1dr3TAPDihydrofolate reductase1.5.1.30.460
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
1gj4132Prothrombin3.4.21.50.460
1l2jETCEstrogen receptor beta/0.460
1pdhFASp-hydroxybenzoate hydroxylase/0.460
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.460
1re7FOLDihydrofolate reductase1.5.1.30.460
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
2nv7555Estrogen receptor beta/0.460
2op18PCEnoyl-ACP reductase/0.460
2vr1ATFBiotin carboxylase6.3.4.140.460
3i1y33NBifunctional epoxide hydrolase 23.3.2.100.460
3juqAKDPhenazine biosynthesis protein A/B/0.460
4f6w0SSCyclin-dependent kinase 82.7.11.220.460
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.460
4hni16WCasein kinase I isoform epsilon2.7.11.10.460
4oeaDHTAndrogen receptor/0.460
4psbGA3Cytokinin-specific binding protein/0.460
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.460
5iqbGNPBifunctional AAC/APH2.3.10.460
1ay0TPPTransketolase 12.2.1.10.459
1drbMTXDihydrofolate reductase1.5.1.30.459
1f4gTP4Thymidylate synthase/0.459
1ie8KH1Vitamin D3 receptor/0.459
1s19MC9Vitamin D3 receptor/0.459
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2mokFMNFlavodoxin 1/0.459
2o6hINI6,7-dimethyl-8-ribityllumazine synthase 12.5.1.780.459
2rtoIMIStreptavidin/0.459
2vcmM11Isopenicillin N synthase1.21.3.10.459
2wuuNHWGlycylpeptide N-tetradecanoyltransferase/0.459
2x7jTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.459
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.459
3c3dFO12-phospho-L-lactate transferase/0.459
3eluSAMMethyltransferase/0.459
3hz142CHeat shock protein HSP 90-alpha/0.459
3nmhPYVAbscisic acid receptor PYL2/0.459
3r336MEDihydrofolate reductase1.5.1.30.459
3v3m0ENReplicase polyprotein 1a3.4.19.120.459
4a81DXCMajor pollen allergen Bet v 1-A/0.459
4g8bHL6Alpha/beta hydrolase fold protein/0.459
4nh82LCHeat shock protein HSP 90-alpha/0.459
4ohaHFTAndrogen receptor/0.459
4qysPLRTryptophan synthase beta chain 24.2.1.200.459
1l2iETCEstrogen receptor/0.458
1mraAPGMandelate racemase/0.458
1pq6965Oxysterols receptor LXR-beta/0.458
1svlADPLarge T antigen3.6.40.458
1thnADPAnti-sigma F factor/0.458
2bfpH4BPteridine reductase 11.5.1.330.458
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.458
2cleF6FTryptophan synthase alpha chain/0.458
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
2g72F21Phenylethanolamine N-methyltransferase2.1.1.280.458
2hamC33Vitamin D3 receptor/0.458
2hcdBIVVitamin D3 receptor A/0.458
2iviACWIsopenicillin N synthase1.21.3.10.458
2j2pSC2Ficolin-2/0.458
2rr1W8RGenome polyprotein/0.458
2yjxYJXHeat shock protein HSP 90-alpha/0.458
2zynBCDPeriplasmic binding protein/0.458
3apwDP0Alpha-1-acid glycoprotein 2/0.458
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3uayADNPurine nucleoside phosphorylase DeoD-type/0.458
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.458
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.458
4mv3ACPBiotin carboxylase6.3.4.140.458
4o71CPBBromodomain-containing protein 4/0.458
4pxmESTEstrogen receptor/0.458
4rrlA3SProbable threonine--tRNA ligase 26.1.1.30.458
5iqiGNPBifunctional AAC/APH2.3.10.458
1culFOKAdenylate cyclase type 2/0.457
1culFOKAdenylate cyclase type 5/0.457
1ml6GBXGlutathione S-transferase A22.5.1.180.457
1r2jFADFkbI/0.457
1ra3MTXDihydrofolate reductase1.5.1.30.457
1txiTX5Vitamin D3 receptor/0.457
2fa3ACOHydroxymethylglutaryl-CoA synthase/0.457
2pg0FADAcyl-CoA dehydrogenase/0.457
2v59LZKBiotin carboxylase6.3.4.140.457
2w3mFOLDihydrofolate reductase1.5.1.30.457
3aosJH2Hemolymph juvenile hormone binding protein/0.457
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.457
3biz61EWee1-like protein kinase2.7.10.20.457
3mnrSD1Heat shock protein HSP 90-alpha/0.457
3pi0F91Endothiapepsin3.4.23.220.457
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.457
3pllF06Endothiapepsin3.4.23.220.457
3w0iO11Vitamin D3 receptor/0.457
4fhi0S4Vitamin D3 receptor A/0.457
4lvb20NNicotinamide phosphoribosyltransferase2.4.2.120.457
4py6R78Bromodomain protein, putative/0.457
4wqmFADToluene-4-monooxygenase electron transfer component1.18.1.30.457
4y3zF41Endothiapepsin3.4.23.220.457
4zasTYDCalS13/0.457
1cjkFOKAdenylate cyclase type 2/0.456
1cjkFOKAdenylate cyclase type 5/0.456
1kqwRTLCellular retinol-binding protein type II/0.456
1nbhSAMGlycine N-methyltransferase2.1.1.200.456
1qiqACCIsopenicillin N synthase1.21.3.10.456
1tl7FOKAdenylate cyclase type 2/0.456
1tl7FOKAdenylate cyclase type 5/0.456
2aaxPDNMineralocorticoid receptor/0.456
2ayrL4GEstrogen receptor/0.456
2hm9TRRDihydrofolate reductase1.5.1.30.456
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.456
2pulACPMethylthioribose kinase2.7.1.1000.456
2q7gCCLPyrrolysine--tRNA ligase/0.456
2q7iTESAndrogen receptor/0.456
2rtkGLLStreptavidin/0.456
2vmyFFOSerine hydroxymethyltransferase/0.456
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.456
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3v1s0LHStrictosidine synthase4.3.3.20.456
4a86H35Major pollen allergen Bet v 1-A/0.456
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.456
4okb198Androgen receptor/0.456
4uugPXGBranched-chain amino acid aminotransferase, putative/0.456
4wx2F6FTryptophan synthase alpha chain/0.456
4wx2F6FTryptophan synthase beta chain4.2.1.200.456
5il2SAHN6-adenosine-methyltransferase 70 kDa subunit/0.456
5uviZMAAdenosine receptor A2a/0.456
1f5fDHTSex hormone-binding globulin/0.455
1hrvSDZGenome polyprotein/0.455
1rc4DDFDihydrofolate reductase1.5.1.30.455
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.455
2g0gSP0Peroxisome proliferator-activated receptor gamma/0.455
2g44T3OEstrogen receptor/0.455
2izkGLLStreptavidin/0.455
2pbzATPUncharacterized protein/0.455
2zioAYBPyrrolysine--tRNA ligase/0.455
3bgrT27Gag-Pol polyprotein2.7.7.490.455
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3ojiPYVAbscisic acid receptor PYL3/0.455
3t7x4SHEndothiapepsin3.4.23.220.455
4rriA3TProbable threonine--tRNA ligase 26.1.1.30.455
1cbqRE9Cellular retinoic acid-binding protein 2/0.454
1l9kSAHGenome polyprotein2.7.7.480.454
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.454
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.454
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.454
1susSAHCaffeoyl-CoA O-methyltransferase2.1.1.1040.454
1uycPU7Heat shock protein HSP 90-alpha/0.454
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.454
2amb17HAndrogen receptor/0.454
2hl2SSAThreonine--tRNA ligase6.1.1.30.454
3d84NDPDihydrofolate reductase1.5.1.30.454
3elePLPAminotransferase/0.454
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
3s3vTOPDihydrofolate reductase1.5.1.30.454
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.454
4a862ANMajor pollen allergen Bet v 1-A/0.454
4g20484Vitamin D3 receptor A/0.454
4imoPWZProstaglandin-H2 D-isomerase5.3.99.20.454
4kiq1RAMitogen-activated protein kinase 14/0.454
4nb6444Nuclear receptor ROR-gamma/0.454
4rrbA3TProbable threonine--tRNA ligase 26.1.1.30.454
4uofDATNucleoside diphosphate kinase/0.454
5iqaGNPBifunctional AAC/APH2.3.10.454
1blzACVIsopenicillin N synthase1.21.3.10.453
1yimCM4Estrogen receptor/0.453
1zw9H64ATP-dependent molecular chaperone HSP82/0.453
2cjfRP43-dehydroquinate dehydratase4.2.1.100.453
3d0bSNXHeat shock protein HSP 90-alpha/0.453
3nr4PYVAbscisic acid receptor PYL2/0.453
3reoEUG(Iso)eugenol O-methyltransferase2.1.1.1460.453
3s1dZIRCytokinin dehydrogenase 11.5.99.120.453
3s79ASDAromatase1.14.14.140.453
3vrvYSDVitamin D3 receptor/0.453
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.453
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4fqsLYAThymidylate synthase ThyA/0.453
4kfbT27Gag-Pol polyprotein2.7.7.490.453
4lgaA2OAbscisic acid receptor PYL2/0.453
4lwbQJ8Nitric oxide synthase oxygenase1.14.13.1650.453
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
1dr5NAPDihydrofolate reductase1.5.1.30.452
1g0rTHMGlucose-1-phosphate thymidylyltransferase/0.452
1i58ACPChemotaxis protein CheA2.7.13.30.452
1qnfHDFDeoxyribodipyrimidine photo-lyase4.1.99.30.452
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.452
1x7jGENEstrogen receptor beta/0.452
1xxjUNCUricase1.7.3.30.452
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.452
2fj1CTCTetracycline repressor protein class D/0.452
2he5NDPAldo-keto reductase family 1 member C211.1.10.452
2w71L23Biotin carboxylase6.3.4.140.452
2y67N21UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.452
2ykiYKIHeat shock protein HSP 90-alpha/0.452
2ylpTESAndrogen receptor/0.452
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3ertOHTEstrogen receptor/0.452
3fnu006HAP protein/0.452
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.452
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3rtnRTNBeta-secretase 13.4.23.460.452
3t2wBTNAvidin/streptavidin/0.452
3uxvGUNNADPH-dependent 7-cyano-7-deazaguanine reductase/0.452
3x0a5GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.452
4iarERM5-hydroxytryptamine receptor 1B/0.452
4jlj1NMDeoxycytidine kinase2.7.1.740.452
4plpNADHomospermidine synthase2.5.1.440.452
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.452
5gcnCOAHAT A1/0.452
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.451
1fmlRTLRetinol dehydratase/0.451
1ia4TQ6Dihydrofolate reductase1.5.1.30.451
1qxlFR8Adenosine deaminase3.5.4.40.451
1wxyFRKAdenosine deaminase3.5.4.40.451
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2on6IMHPurine nucleoside phosphorylase2.4.2.10.451
2zl9VDAVitamin D3 receptor/0.451
3br3ETHTH-type transcriptional regulator QacR/0.451
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
3negPYVAbscisic acid receptor PYL1/0.451
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
3rinI2OMitogen-activated protein kinase 14/0.451
4gqe6KJNitric oxide synthase, brain1.14.13.390.451
4hh0FMNAppA protein/0.451
4l8u9AZSerum albumin/0.451
4mubOAQSulfotransferase oxamniquine resistance protein/0.451
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.451
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.451
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.451
1hfqMOTDihydrofolate reductase1.5.1.30.450
1kmvLIIDihydrofolate reductase1.5.1.30.450
1n4hREANuclear receptor ROR-beta/0.450
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.450
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.450
1synF89Thymidylate synthase/0.450
1tkaN3TTransketolase 12.2.1.10.450
1xddAAYIntegrin alpha-L/0.450
1z6tADPApoptotic protease-activating factor 1/0.450
2fduD1GCytochrome P450 2A61.14.130.450
2jdcCAOProbable acetyltransferase/0.450
2q7kTESAndrogen receptor/0.450
2rm2W43Genome polyprotein/0.450
2vkmBSDBeta-secretase 13.4.23.460.450
2vt4P32Beta-1 adrenergic receptor/0.450
2w6oOA3Biotin carboxylase6.3.4.140.450
2zlaVDBVitamin D3 receptor/0.450
3btjDEQHTH-type transcriptional regulator QacR/0.450
3exfTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.450
3exfTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.450
3g11P9C3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.450
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.450
3pahXDEPhenylalanine-4-hydroxylase1.14.16.10.450
3q5kD1UHeat shock protein 83-1/0.450
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.450
3up0D7SaceDAF-12/0.450
3up3XCAaceDAF-12/0.450
4at0FADPossible succinate dehydrogenase/0.450
4fkxCDPNucleoside diphosphate kinase/0.450
4itfTFYVitamin D3 receptor/0.450
4m8e29VRetinoic acid receptor RXR-alpha/0.450
4n1gCEIObelin/0.450
4qo9627Serine/threonine-protein kinase 242.7.11.10.450
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.450
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.450
5k2bZMAAdenosine receptor A2a/0.450
1cqp803Integrin alpha-L/0.449
1dghNDPCatalase1.11.1.60.449
1dyhDZFDihydrofolate reductase1.5.1.30.449
1gvv0GMEndothiapepsin3.4.23.220.449
1kekHTLPyruvate synthase/0.449
1lbbKAIGlutamate receptor 2/0.449
1nq7ARLNuclear receptor ROR-beta/0.449
1opbRETRetinol-binding protein 2/0.449
1rt4UC1Gag-Pol polyprotein2.7.7.490.449
1rx7FOLDihydrofolate reductase1.5.1.30.449
1u71MXADihydrofolate reductase1.5.1.30.449
2acwUPGGlycosyltransferase/0.449
2bxmIMNSerum albumin/0.449
2e0nSAHPrecorrin-2 C20-methyltransferase/0.449
2g8yNADHydroxycarboxylate dehydrogenase B/0.449
2ji9TPWOxalyl-CoA decarboxylase4.1.1.80.449
2qg2A91Heat shock protein HSP 90-alpha/0.449
2qo9ANPEphrin type-A receptor 32.7.10.10.449
2rtiGLLStreptavidin/0.449
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.449
2wo7ASVIsopenicillin N synthase1.21.3.10.449
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.449
3elySAHMethyltransferase/0.449
3jzfJZKBiotin carboxylase6.3.4.140.449
3mneDEXGlucocorticoid receptor/0.449
3oht1N1Mitogen-activated protein kinase/0.449
3qiyQI1Botulinum neurotoxin type A3.4.24.690.449
3rl35GPMetallophosphoesterase MPPED23.10.449
3w4k3LDD-amino-acid oxidase1.4.3.30.449
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
4j6cSTRCytochrome P450 monooxygenase/0.449
4jq8KJ8Epidermal growth factor receptor2.7.10.10.449
4k6mSAHGenome polyprotein/0.449
4mgkCMPRap guanine nucleotide exchange factor 4/0.449
1bnnAL1Carbonic anhydrase 24.2.1.10.448
1db1VDXVitamin D3 receptor/0.448
1dr4HBIDihydrofolate reductase1.5.1.30.448
1lriCLRBeta-elicitin cryptogein/0.448
1p0pBCHCholinesterase3.1.1.80.448
1p8dCO1Oxysterols receptor LXR-beta/0.448
1rx4DDFDihydrofolate reductase1.5.1.30.448
1tduDURThymidylate synthase/0.448
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.448
2fwyH64Heat shock protein HSP 90-alpha/0.448
2hvcLGDAndrogen receptor/0.448
2r0pK2CPutative FAD-monooxygenase/0.448
2v0uFMNNPH1-1/0.448
2wjoQUDBeta-secretase 13.4.23.460.448
2ykeYKEHeat shock protein HSP 90-alpha/0.448
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.448
3dd125DGlycogen phosphorylase, liver form2.4.1.10.448
3fl8RARDihydrofolate reductase/0.448
3gkjHC3Niemann-Pick C1 protein/0.448
3h3qH13Collagen type IV alpha-3-binding protein/0.448
3l0lHC3Nuclear receptor ROR-gamma/0.448
3m7rVDXVitamin D3 receptor/0.448
3nj0PYVAbscisic acid receptor PYL2/0.448
3q95ESLEstrogen receptor/0.448
3t37FADPyridoxine 4-oxidase/0.448
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.448
3zraORBProgesterone receptor/0.448
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.448
4ax8ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.448
4e0u0MVCyclic dipeptide N-prenyltransferase/0.448
4fflADPUncharacterized protein/0.448
4fvrATPTyrosine-protein kinase JAK2/0.448
4j0s1H3Bromodomain-containing protein 4/0.448
4jdaA9SAbscisic acid receptor PYL3/0.448
4o95245Cytokinin dehydrogenase 4/0.448
5dxgESTEstrogen receptor/0.448
5k2cZMAAdenosine receptor A2a/0.448
3sn6P0GBeta-2 adrenergic receptor/0.448
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1hb3SCVIsopenicillin N synthase1.21.3.10.447
1obnASVIsopenicillin N synthase1.21.3.10.447
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.447
1suoCPZCytochrome P450 2B41.14.14.10.447
1t7rDHTAndrogen receptor/0.447
1xp6AIUEstrogen receptor/0.447
2c3u2TPPyruvate synthase/0.447
2cjpVPREpoxide hydrolase/0.447
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.447
2jlaTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.447
2m56CAMCamphor 5-monooxygenase1.14.15.10.447
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
2rehFADNitroalkane oxidase1.7.3.10.447
2xx513NATP-dependent molecular chaperone HSP82/0.447
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3fhxPLPPyridoxal kinase2.7.1.350.447
3hz5Z64Heat shock protein HSP 90-alpha/0.447
3i53SAH2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.447
3inxJZCHeat shock protein HSP 90-alpha/0.447
3lakKR1Gag-Pol polyprotein2.7.7.490.447
3nmpPYVAbscisic acid receptor PYL2/0.447
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.447
3p67FMNPentaerythritol tetranitrate reductase/0.447
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3wtkTH4Acetylcholine-binding protein/0.447
4a87NARMajor pollen allergen Bet v 1-A/0.447
4awq592Heat shock protein HSP 90-alpha/0.447
4bdoKAIGlutamate receptor ionotropic, kainate 2/0.447
4ffrATPUncharacterized protein/0.447
4k9yK9YFocal adhesion kinase 12.7.10.20.447
4kwi1TJReductase homolog/0.447
4nbwNADShort-chain dehydrogenase/reductase SDR/0.447
4rrdA3TProbable threonine--tRNA ligase 26.1.1.30.447
4rrkA3TProbable threonine--tRNA ligase 26.1.1.30.447
4u7wNDPMxaA/0.447
1dr3HBIDihydrofolate reductase1.5.1.30.446
1g9rUPFLgtC/0.446
1hb1OCVIsopenicillin N synthase1.21.3.10.446
1jnzFADAdenylylsulfate reductase, subunit A (AprA)/0.446
1jomFFODihydrofolate reductase1.5.1.30.446
1nenDNTSuccinate dehydrogenase iron-sulfur subunit1.3.5.10.446
1nenDNTSuccinate dehydrogenase cytochrome b556 subunit/0.446
1qjfACSIsopenicillin N synthase1.21.3.10.446
1uykPUXHeat shock protein HSP 90-alpha/0.446
1x7e244Estrogen receptor/0.446
2bf7HBIPteridine reductase 11.5.1.330.446
2c4iBTNAvidin/0.446
2f2uM77Rho-associated protein kinase 22.7.11.10.446
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
2hl0A3SThreonine--tRNA ligase6.1.1.30.446
2j0sANPEukaryotic initiation factor 4A-III3.6.4.130.446
2pipDHTAndrogen receptor/0.446
2puhHPK2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase3.7.1.80.446
2zwaSAHtRNA wybutosine-synthesizing protein 42.1.1.2900.446
2zymACXPeriplasmic binding protein/0.446
3akzGSUGlutamate--tRNA ligase 2/0.446
3c3xNAPEugenol synthase 11.1.1.3180.446
3d9zD9ZCarbonic anhydrase 24.2.1.10.446
3dazMZMCarbonic anhydrase 24.2.1.10.446
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.446
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.446
3ipq965Oxysterols receptor LXR-alpha/0.446
3m09RARDihydrofolate reductase1.5.1.30.446
3m4nPA9N-acetylornithine carbamoyltransferase2.1.3.90.446
3njuANNAcidic phospholipase A2 33.1.1.40.446
3nrcTCLEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.446
3tkyN7I(Iso)eugenol O-methyltransferase2.1.1.1460.446
3vrtYS2Vitamin D3 receptor/0.446
4ctjSAMGenome polyprotein/0.446
4dpy2P0Mevalonate diphosphate decarboxylase/0.446
4gk3L87Ephrin type-A receptor 32.7.10.10.446
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.446
4oh5HFTAndrogen receptor/0.446
4rr6A3SProbable threonine--tRNA ligase 26.1.1.30.446
4twpAXITyrosine-protein kinase ABL12.7.10.20.446
4xnhACON-terminal acetyltransferase A complex subunit NAT52.3.10.446
1dliUDXUDP-glucose 6-dehydrogenase/0.445
1e92HBIPteridine reductase 11.5.1.330.445
1fvpFMANon-fluorescent flavoprotein/0.445
1og5SWFCytochrome P450 2C9/0.445
1u3r338Estrogen receptor beta/0.445
1w06W05Isopenicillin N synthase1.21.3.10.445
1w1rZEACytokinin dehydrogenase 11.5.99.120.445
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
2ftoCB3Thymidylate synthase/0.445
2gbyBRNHTH-type transcriptional regulator QacR/0.445
2harOCCVitamin D3 receptor/0.445
2iogIOGEstrogen receptor/0.445
2piuDHTAndrogen receptor/0.445
2pnuENMAndrogen receptor/0.445
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
2yee2ECHeat shock protein HSP 90-alpha/0.445
2yhdTESAndrogen receptor/0.445
3bbfGDPNucleoside diphosphate kinase B2.7.4.60.445
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.445
3e2sFADBifunctional protein PutA1.5.5.20.445
3eksCY9Actin-5C/0.445
3fznD7KBenzoylformate decarboxylase4.1.1.70.445
3ghh2NFCD38 molecule/0.445
3lz6A0DCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3uudESTEstrogen receptor/0.445
4bqrIBHEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4cavMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.445
4dscA8SAbscisic acid receptor PYL3/0.445
4g1y0VOVitamin D3 receptor A/0.445
4gg70J8Hepatocyte growth factor receptor2.7.10.10.445
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.445
4jtqFLPAldo-keto reductase family 1 member C2/0.445
4mryCEIObelin/0.445
4mv4ACPBiotin carboxylase6.3.4.140.445
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.445
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.445
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.445
4ys22BAUncharacterized protein/0.445
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.445
5k2dZMAAdenosine receptor A2a/0.445
1ef92CPMethylmalonyl-CoA decarboxylase4.1.1.410.444
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.444
1mabADPATP synthase subunit beta, mitochondrial3.6.3.140.444
1ppl1Z7Penicillopepsin-13.4.23.200.444
1s1vTNKGag-Pol polyprotein2.7.7.490.444
1s4eADPGalactokinase/0.444
1sreHABStreptavidin/0.444
1x8b824Wee1-like protein kinase2.7.10.20.444
1x8lOXRRetinol dehydratase/0.444
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
2bakAQZMitogen-activated protein kinase 14/0.444
2d29FADAcyl-CoA dehydrogenase/0.444
2drcMTXDihydrofolate reductase1.5.1.30.444
2jf9OHTEstrogen receptor/0.444
2jibTPPOxalyl-CoA decarboxylase4.1.1.80.444
2pklDHTAndrogen receptor/0.444
2q7lTESAndrogen receptor/0.444
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.444
3i6rJ5ZDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.444
3lfcZ86Mitogen-activated protein kinase 14/0.444
3ntz3TZDihydrofolate reductase1.5.1.30.444
3pbzF02Endothiapepsin3.4.23.220.444
3ry2BTNStreptavidin/0.444
3uvvREARetinoic acid receptor RXR-alpha/0.444
4a9yAQZMitogen-activated protein kinase 14/0.444
4dfrMTXDihydrofolate reductase1.5.1.30.444
4yal2AMNADPH--cytochrome P450 reductase/0.444
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.444
1coyANDCholesterol oxidase1.1.3.60.443
1dg8NDPDihydrofolate reductase1.5.1.30.443
1dhiMTXDihydrofolate reductase1.5.1.30.443
1g1aNADdTDP-glucose 4,6-dehydratase/0.443
1hvyD16Thymidylate synthase2.1.1.450.443
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.443
1ogiFADFerredoxin--NADP reductase1.18.1.20.443
1pq944BOxysterols receptor LXR-beta/0.443
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.443
1s6qTPBGag-Pol polyprotein2.7.7.490.443
1sriDMBStreptavidin/0.443
1u3q272Estrogen receptor beta/0.443
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2a2xNA9Prothrombin3.4.21.50.443
2bdyUNBProthrombin3.4.21.50.443
2c3p1TPPyruvate synthase/0.443
2dvlFADAcyl-CoA dehydrogenase/0.443
2jedLG8Protein kinase C theta type2.7.11.130.443
2pl0STITyrosine-protein kinase Lck2.7.10.20.443
2qcxPF1Aminopyrimidine aminohydrolase/0.443
2vczVC3Hematopoietic prostaglandin D synthase/0.443
2zjmF1MBeta-secretase 13.4.23.460.443
3a0iAJIGlucokinase2.7.1.20.443
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
3fwjCAMCamphor 5-monooxygenase1.14.15.10.443
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.443
3h4vNAPPteridine reductase 11.5.1.330.443
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.443
3hz137DHeat shock protein HSP 90-alpha/0.443
3iaaTYDCalG2/0.443
3zgl10E4-hydroxy-3-methylbut-2-enyl diphosphate reductase/0.443
3zrbORCProgesterone receptor/0.443
4a83DXCMajor pollen allergen Bet v 1-A/0.443
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.443
4b6s2HN3-dehydroquinate dehydratase4.2.1.100.443
4bx7B4FStreptavidin/0.443
4dptAGSMevalonate diphosphate decarboxylase/0.443
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4g67SAHUncharacterized ACR, COG1565 superfamily/0.443
4j24ESTEstrogen receptor beta/0.443
4kebFOLDihydrofolate reductase1.5.1.30.443
4ng2OHNTranscriptional activator protein LasR/0.443
4xfjANPArgininosuccinate synthase/0.443
5hbsRTLRetinol-binding protein 1/0.443
1al7HSTPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.442
1cbsREACellular retinoic acid-binding protein 2/0.442
1dduCB3Thymidylate synthase/0.442
1fm99CRRetinoic acid receptor RXR-alpha/0.442
1i9hBNIStreptavidin/0.442
1omoNADAlanine dehydrogenase/0.442
1srjNABStreptavidin/0.442
1uy9PU6Heat shock protein HSP 90-alpha/0.442
1z5cADPType 2 DNA topoisomerase 6 subunit B/0.442
2ao6R18Androgen receptor/0.442
2bfaCB3Pteridine reductase 11.5.1.330.442
2bp1NDPAflatoxin B1 aldehyde reductase member 2/0.442
2fwzH71Heat shock protein HSP 90-alpha/0.442
2j7yE3OEstrogen receptor beta/0.442
2ouzC3DEstrogen receptor/0.442
2p1u4TNRetinoic acid receptor RXR-alpha/0.442
2p1v5TNRetinoic acid receptor RXR-alpha/0.442
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.442
2pioDHTAndrogen receptor/0.442
2pirDHTAndrogen receptor/0.442
2rs1W84Genome polyprotein/0.442
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
3l034OHEstrogen receptor/0.442
3nmvPYVAbscisic acid receptor PYL2/0.442
3pm1ETHTH-type transcriptional regulator QacR/0.442
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.442
3t88S0N1,4-dihydroxy-2-naphthoyl-CoA synthase/0.442
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.442
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.442
3vt65YIVitamin D3 receptor/0.442
3vv8B02Beta-secretase 13.4.23.460.442
4bhw01KHistone acetyltransferase p300/0.442
4burNADApoptosis-inducing factor 1, mitochondrial1.1.10.442
4c66H4CBromodomain-containing protein 4/0.442
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.442
4f3gKAIGlutamate receptor 3/0.442
4j6dTESCytochrome P450 monooxygenase/0.442
4okw198Androgen receptor/0.442
5pahLDPPhenylalanine-4-hydroxylase1.14.16.10.442
7catNDPCatalase1.11.1.60.442
1getNAPGlutathione reductase1.8.1.70.441
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.441
1jtuLYBThymidylate synthase/0.441
1p33MTXPteridine reductase 11.5.1.330.441
1t90NADMalonate-semialdehyde dehydrogenase1.2.1.270.441
1xq3R18Androgen receptor/0.441
2ojg19AMitogen-activated protein kinase 12.7.11.240.441
2p1dSAHGenome polyprotein2.7.7.480.441
2pamTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.441
2vq5LDPS-norcoclaurine synthase/0.441
2yx6ADPUncharacterized protein/0.441
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3erdDESEstrogen receptor/0.441
3gagFMNPutative NADH dehydrogenase NAD(P)H nitroreductase/0.441
3hf6LX0Tryptophan 5-hydroxylase 11.14.16.40.441
3inwJZBHeat shock protein HSP 90-alpha/0.441
3k8q22APurine nucleoside phosphorylase2.4.2.10.441
3koo24DBifunctional epoxide hydrolase 23.3.2.100.441
3t3r9PLCytochrome P450 2A61.14.130.441
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
3vt7VDXVitamin D3 receptor/0.441
3wo0ADPAlanine--anticapsin ligase/0.441
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4bfxZVXPantothenate kinase2.7.1.330.441
4deg0JJHepatocyte growth factor receptor2.7.10.10.441
4foxD16Thymidylate synthase ThyA/0.441
4hlwTESAndrogen receptor/0.441
4iw8KN3Estrogen receptor/0.441
4ofrDHTAndrogen receptor/0.441
4qzuRTLRetinol-binding protein 2/0.441
4wa9AXITyrosine-protein kinase ABL12.7.10.20.441
4yjdFADD-amino-acid oxidase1.4.3.30.441
1aiqCB3Thymidylate synthase/0.440
1e2nRCAThymidine kinase/0.440
1kziTHGThymidylate synthase/0.440
1n0uSO1Elongation factor 2/0.440
1o5rFR9Adenosine deaminase3.5.4.40.440
1qxoFMNChorismate synthase/0.440
1rkhVD2Vitamin D3 receptor/0.440
1towCRZFatty acid-binding protein, adipocyte/0.440
1umlFR4Adenosine deaminase3.5.4.40.440
1uomPTIEstrogen receptor/0.440
1uydPU8Heat shock protein HSP 90-alpha/0.440
1uyuCAMCamphor 5-monooxygenase1.14.15.10.440
1vyw292Cyclin-dependent kinase 22.7.11.220.440
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.440
2fhnBNIAvidin-related protein 4/5/0.440
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.440
2gvcFADThiol-specific monooxygenase1.14.130.440
2i5nUQ1Reaction center protein L chain/0.440
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.440
2piqDHTAndrogen receptor/0.440
2pixDHTAndrogen receptor/0.440
2v8pCDP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.440
2va7C27Beta-secretase 13.4.23.460.440
2w3bNDPDihydrofolate reductase1.5.1.30.440
2webPP4Penicillopepsin-13.4.23.200.440
2wehFB1Carbonic anhydrase 24.2.1.10.440
2zfq45UProthrombin3.4.21.50.440
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.440
3fl9TOPDihydrofolate reductase/0.440
3p5sAVUCD38 molecule/0.440
3p9tTCLRepressor/0.440
3rtmRTMBeta-secretase 13.4.23.460.440
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.440
3uptTPPTransketolase/0.440
3vf60H6Glucokinase2.7.1.20.440
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.440
4a9oA9OBromodomain-containing protein 2/0.440
4aoxFADSteroid monooxygenase/0.440
4b5bBBEGlucose-1-phosphate thymidylyltransferase/0.440
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4bjx73BBromodomain-containing protein 4/0.440
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.440
4fj1GEN17beta-hydroxysteroid dehydrogenase/0.440
4g47TZFMycocyclosin synthase1.14.21.90.440
4k9oTPPBenzoylformate decarboxylase4.1.1.70.440
4kxjP34Nucleoprotein/0.440
4n3r2GUTankyrase-12.4.2.300.440
4o701QKBromodomain-containing protein 4/0.440
4ocvANPAminoglycoside phosphotransferase/0.440
4oedDHTAndrogen receptor/0.440
4uohADPNucleoside diphosphate kinase/0.440
4x5hFOLDihydrofolate reductase1.5.1.30.440
5iubCLRAdenosine receptor A2a/0.440