scPDB - Distribution of Cavity Similarity values of 1dr2 entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1dr2	TAP	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
1dr2	TAP	Dihydrofolate reductase	1.5.1.3	1.000
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.821
1dr5	NAP	Dihydrofolate reductase	1.5.1.3	0.797
1dr3	TAP	Dihydrofolate reductase	1.5.1.3	0.787
8dfr	NDP	Dihydrofolate reductase	1.5.1.3	0.749
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.557
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.552
3d84	NDP	Dihydrofolate reductase	1.5.1.3	0.540
3nxx	NDP	Dihydrofolate reductase	1.5.1.3	0.539
2h2q	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.525
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.524
3kjs	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.522
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.521
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.519
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.513
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.512
1ai9	NDP	Dihydrofolate reductase	1.5.1.3	0.510
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.509
2w3b	NDP	Dihydrofolate reductase	1.5.1.3	0.509
3inv	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.506
3clb	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.505
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.502
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.497
3qls	NDP	Dihydrofolate reductase	1.5.1.3	0.496
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.490
4m6j	NDP	Dihydrofolate reductase	1.5.1.3	0.489
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.487
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.486
1dg8	NDP	Dihydrofolate reductase	1.5.1.3	0.485
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.485
3dga	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.485
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.485
3hbb	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.485
3dg8	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.480
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.479
3tqa	NDP	Dihydrofolate reductase	/	0.479
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.477
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.477
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	0.476
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.471
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.470
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.465
1ia1	NDP	Dihydrofolate reductase	1.5.1.3	0.461
3qlr	NDP	Dihydrofolate reductase	1.5.1.3	0.460
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.459
3kjr	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.459
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.456
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.456
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.455
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.454
4kl9	NDP	Dihydrofolate reductase	1.5.1.3	0.454
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.450
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.450
5ecc	NAP	Dehydrofolate reductase type I	/	0.449
1j3k	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.448
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.445
1j3j	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.445
4kne	1CY	Dihydrofolate reductase	1.5.1.3	0.444
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.443
1ra8	FOL	Dihydrofolate reductase	1.5.1.3	0.443
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.443
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.443
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.443
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.441
1m78	NDP	Dihydrofolate reductase	1.5.1.3	0.440