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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dlsMTXDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1dlsMTXDihydrofolate reductase1.5.1.31.000
1u72MTXDihydrofolate reductase1.5.1.30.576
2w3mFOLDihydrofolate reductase1.5.1.30.544
4kebFOLDihydrofolate reductase1.5.1.30.537
1hfrMOTDihydrofolate reductase1.5.1.30.535
4m6kFOLDihydrofolate reductase1.5.1.30.533
3ghwGHWDihydrofolate reductase1.5.1.30.526
3gi2GHWDihydrofolate reductase1.5.1.30.520
4kfjFOLDihydrofolate reductase1.5.1.30.506
1hfpMOTDihydrofolate reductase1.5.1.30.501
1ohkCOPDihydrofolate reductase1.5.1.30.497
3l3rOAGDihydrofolate reductase1.5.1.30.494
4m6l21VDihydrofolate reductase1.5.1.30.487
3gyf51PDihydrofolate reductase1.5.1.30.483
1ohjCOPDihydrofolate reductase1.5.1.30.478
1kmsLIHDihydrofolate reductase1.5.1.30.469
1hfqMOTDihydrofolate reductase1.5.1.30.463
3nu03TUDihydrofolate reductase1.5.1.30.463
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.462
3ntz3TZDihydrofolate reductase1.5.1.30.459
2fzjDH3Dihydrofolate reductase1.5.1.30.449
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
3k4551PDihydrofolate reductase1.5.1.30.447