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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dhrNADDihydropteridine reductase1.5.1.34

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1dhrNADDihydropteridine reductase1.5.1.341.000
1dirNADDihydropteridine reductase1.5.1.340.599
1hdrNADDihydropteridine reductase1.5.1.340.549
3orfNADDihydropteridine reductase1.5.1.340.522
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.472
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.468
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.465
1bwsNDPGDP-L-fucose synthase/0.457
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.457
4nbwNADShort-chain dehydrogenase/reductase SDR/0.455
3q43D66M1 family aminopeptidase3.4.110.454
1k6cMK1Gag-Pol polyprotein3.4.23.160.452
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.452
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.450
2c29NAPDihydroflavonol 4-reductase/0.448
4dc0NDPPutative ketoacyl reductase1.3.10.448
4qecNAPElxO/0.447
2g8yNADHydroxycarboxylate dehydrogenase B/0.444
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.444
2dteNAIGlucose 1-dehydrogenase related protein/0.443
3ig6438Urokinase-type plasminogen activator3.4.21.730.442
4dbzNDPPutative ketoacyl reductase1.3.10.441
4q71FADBifunctional protein PutA/0.441