sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1dhj	MTX	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	1.000
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.748
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.656
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.644
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.635
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.628
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	0.581
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.540
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.537
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.531
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.516
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.515
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.508
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	0.498
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.491
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.474
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.467
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.448
5hi6	MTX	Dihydrofolate reductase	/	0.443