sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1dhi	MTX	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	1.000
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.750
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.623
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.617
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.582
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.570
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.559
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.547
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.538
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	0.534
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.530
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.526
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.508
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.506
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.504
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.501
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.492
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.484
3clb	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.440