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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ddrMTXDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1ddrMTXDihydrofolate reductase1.5.1.31.000
1ddsMTXDihydrofolate reductase1.5.1.30.699
1re7FOLDihydrofolate reductase1.5.1.30.636
4dfrMTXDihydrofolate reductase1.5.1.30.636
2drcMTXDihydrofolate reductase1.5.1.30.612
1draMTXDihydrofolate reductase1.5.1.30.595
1dyjDDFDihydrofolate reductase1.5.1.30.585
1dyhDZFDihydrofolate reductase1.5.1.30.574
1dyiFOLDihydrofolate reductase1.5.1.30.572
1dhjMTXDihydrofolate reductase1.5.1.30.567
3och2MXDihydrofolate reductase1.5.1.30.561
1rb3MTXDihydrofolate reductase1.5.1.30.554
1rb2FOLDihydrofolate reductase1.5.1.30.531
1jolFFODihydrofolate reductase1.5.1.30.525
3drcMTXDihydrofolate reductase1.5.1.30.520
1tdrMTXDihydrofolate reductase1.5.1.30.513
1drbMTXDihydrofolate reductase1.5.1.30.512
5hi6MTXDihydrofolate reductase/0.499
1ra3MTXDihydrofolate reductase1.5.1.30.494
1rd7FOLDihydrofolate reductase1.5.1.30.484
4x5iFOLDihydrofolate reductase1.5.1.30.482
4x5jFOLDihydrofolate reductase1.5.1.30.482
4cd2FOLDihydrofolate reductase1.5.1.30.479
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
1dhiMTXDihydrofolate reductase1.5.1.30.454
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.446
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440