sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1db4 | 8IN | Phospholipase A2, membrane associated |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 1.000 | |
| 1dcy | I3N | Phospholipase A2, membrane associated | / | 0.751 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.655 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.612 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.550 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.517 | |
| 1kvo | OAP | Phospholipase A2, membrane associated | / | 0.505 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.499 | |
| 3nju | ANN | Acidic phospholipase A2 3 | 3.1.1.4 | 0.486 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.473 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.464 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.459 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.458 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 2oli | IOP | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.457 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 4lb2 | DM5 | Serum albumin | / | 0.457 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.456 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 4hmb | PZZ | Phospholipase A2 VRV-PL-VIIIa | / | 0.454 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.453 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 4qmy | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.452 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.449 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.449 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 1ep4 | S11 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.446 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
| 1eio | GCH | Gastrotropin | / | 0.445 | |
| 1vbm | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.445 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.445 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1fml | RTL | Retinol dehydratase | / | 0.442 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.442 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.442 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.440 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.440 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.440 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.440 | |
| 4l4x | NDP | AmphI | / | 0.440 |