sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.649 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.616 | |
| 3eel | 53T | Uncharacterized protein | / | 0.613 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.596 | |
| 3eej | 53R | Uncharacterized protein | / | 0.595 | |
| 3qly | 55V | Uncharacterized protein | / | 0.592 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.592 | |
| 3cse | N22 | Uncharacterized protein | / | 0.590 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.589 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.588 | |
| 3eem | 53V | Uncharacterized protein | / | 0.588 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.588 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.587 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.584 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.583 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.583 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.582 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.579 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.579 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.577 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.576 | |
| 3eek | 53S | Uncharacterized protein | / | 0.572 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.572 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.572 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.571 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.570 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.560 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.558 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.558 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.555 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.550 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.542 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.541 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.538 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.538 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.534 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.525 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.520 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.518 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.513 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.512 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.510 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.510 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.510 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.508 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.502 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.499 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.496 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.496 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.491 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.490 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.486 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.485 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.483 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.480 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.477 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.477 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.476 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.472 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.471 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.471 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.471 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.470 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 1m8i | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.469 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.468 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.468 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.468 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.467 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.467 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.466 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3b9l | AZZ | Serum albumin | / | 0.465 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.464 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.463 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.463 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.462 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.462 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.461 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.461 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1err | RAL | Estrogen receptor | / | 0.460 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.460 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.460 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.459 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.458 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.457 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.457 | |
| 3h1j | SMA | Cytochrome b | / | 0.457 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.457 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.456 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.456 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.456 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.455 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.455 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.455 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.454 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.454 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.454 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.454 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.453 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.453 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.453 | |
| 2p15 | EZT | Estrogen receptor | / | 0.453 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.453 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2acw | UPG | Glycosyltransferase | / | 0.452 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.452 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.452 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4kb8 | 1QN | Casein kinase I isoform delta | 2.7.11.1 | 0.452 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.452 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.451 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.451 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.451 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.451 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.451 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.450 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.450 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.450 | |
| 2xvv | 9DN | Serum albumin | / | 0.450 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.450 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.450 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.449 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 3v49 | PK0 | Androgen receptor | / | 0.449 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.448 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.448 | |
| 1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.447 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.447 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.447 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.447 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.447 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.446 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.446 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4hai | I23 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.446 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.445 | |
| 1pp9 | SMA | Cytochrome b | / | 0.445 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.445 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.445 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.445 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1yin | CM3 | Estrogen receptor | / | 0.444 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.444 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.444 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.444 | |
| 4xwt | U5P | Ribonuclease J | / | 0.444 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.443 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2wet | FAD | Tryptophan 5-halogenase | / | 0.443 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.443 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.442 | |
| 1sqv | UHD | Cytochrome b | / | 0.442 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.442 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.442 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4zas | TYD | CalS13 | / | 0.442 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.442 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.441 | |
| 1g69 | TZP | Thiamine-phosphate synthase | / | 0.441 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.441 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.441 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3sfi | 3SF | HTH-type transcriptional regulator EthR | / | 0.441 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.441 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.441 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.441 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.441 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.441 | |
| 1wrl | TFP | Troponin C, slow skeletal and cardiac muscles | / | 0.440 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3reo | EUG | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.440 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.440 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.440 | |
| 5il2 | SAH | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.440 |