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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1d4dFADFumarate reductase flavoprotein subunit1.3.5.4

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1d4dFADFumarate reductase flavoprotein subunit1.3.5.41.000
1d4cFADFumarate reductase flavoprotein subunit1.3.5.40.575
1qo8FADFumarate reductase flavoprotein subunit/0.574
1knrFADL-aspartate oxidase1.4.3.160.504
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.493
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.490
3ctyFADProbable thioredoxin reductase/0.485
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.485
5c3jFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.481
1kf6FADFumarate reductase flavoprotein subunit1.3.5.40.480
2rgoFADAlpha-Glycerophosphate Oxidase/0.456
5l3dFADLysine-specific histone demethylase 1A10.454
2du8FADD-amino-acid oxidase1.4.3.30.450
3sfeFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.449
4udqFAD5-(hydroxymethyl)furfural oxidase/0.447
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.445
4c3xFAD3-ketosteroid dehydrogenase/0.444
4yntFDAGlucose oxidase, putative/0.444
1wamFADUDP-galactopyranose mutase5.4.99.90.443
3vqrFADPutative oxidoreductase/0.443
4ap3FADSteroid monooxygenase/0.443
1v0jFADUDP-galactopyranose mutase5.4.99.90.441
4yshFADGlycine oxidase/0.441
4at0FADPossible succinate dehydrogenase/0.440
4h4yFADBiphenyl dioxygenase ferredoxin reductase subunit/0.440
4udrFAD5-(hydroxymethyl)furfural oxidase/0.440