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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1cxzGSPTransforming protein RhoA

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1cxzGSPTransforming protein RhoA/1.000
1kmqGNPTransforming protein RhoA/0.598
2gcpGSPRho-related GTP-binding protein RhoC/0.577
1m7bGTPRho-related GTP-binding protein RhoE/0.570
3kz1GSPTransforming protein RhoA/0.563
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.555
1s1cGNPTransforming protein RhoA/0.547
5hpyGDPTransforming protein RhoA/0.539
1z2cGNPRho-related GTP-binding protein RhoC/0.523
4kvgGTPRas-related protein Rap-1A/0.517
1xtrGNPGTP-binding protein Rheb/0.516
1zc3GNPRas-related protein Ral-A/0.515
3lbnGNPGTPase HRas/0.513
4mitGTPRho-related protein racC/0.508
3eg5GNPCell division control protein 42 homolog/0.507
1zc4GNPRas-related protein Ral-A/0.506
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.503
3a58GNPGTP-binding protein RHO1/0.497
1g17GNPRas-related protein SEC4/0.496
3i3sGNPGTPase HRas/0.488
1xtsGTPGTP-binding protein Rheb/0.486
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.485
2gilGTPRas-related protein Rab-6A/0.483
3th5GNPRas-related C3 botulinum toxin substrate 1/0.482
2clsGTPRho-related GTP-binding protein Rho6/0.481
3oivGNPGTPase HRas/0.479
4js0GNPCell division control protein 42 homolog/0.477
1ow3GDPTransforming protein RhoA/0.475
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.474
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.471
3v4fGNPGTPase HRas/0.471
4lhwGNPRas-related protein Rab-8A/0.470
3rabGNPRas-related protein Rab-3A/0.468
5b2zGNPGTPase HRas/0.465
3kucGDPRas-related protein Rap-1A/0.464
3oiuGNPGTPase HRas/0.464
4nyiGNPGTPase HRas/0.462
3rs5GNPGTPase HRas/0.457
4dxaGSPRas-related protein Rap-1b/0.454
4cymGCPRas-related protein Rab-32/0.452
1yzqGNPRas-related protein Rab-6A/0.450
5dhaGNPGTP-binding nuclear protein Ran/0.450
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.449
2zetGTPRas-related protein Rab-27B/0.447
1a2bGSPTransforming protein RhoA/0.446
1t91GTPRas-related protein Rab-7a/0.446
1gwnGTPRho-related GTP-binding protein RhoE/0.445
4dltGNPGTPase HRas/0.445
3e5hGNPRas-related protein Rab-28/0.444
3bbpGTPRas-related protein Rab-6A/0.443
3tklGTPRas-related protein Rab-1A/0.440