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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1cx2S58Prostaglandin G/H synthase 21.14.99.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1cx2S58Prostaglandin G/H synthase 21.14.99.11.000
6coxS58Prostaglandin G/H synthase 21.14.99.10.561
5ikqJMSProstaglandin G/H synthase 21.14.99.10.526
4otyLURProstaglandin G/H synthase 21.14.99.10.512
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.472
1ht5FL2Prostaglandin G/H synthase 11.14.99.10.460
2oyuIMSProstaglandin G/H synthase 11.14.99.10.459
3kk6CELProstaglandin G/H synthase 11.14.99.10.459
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.455
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.455
3b6zCO7Enoyl reductase LovC10.448
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.447
4rrxLURProstaglandin G/H synthase 21.14.99.10.447
1diuBDMDihydrofolate reductase1.5.1.30.445
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.445
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.443
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.443