sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 1.000 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.640 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.630 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.611 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.607 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.568 | |
| 1d7x | SPC | Stromelysin-1 | 3.4.24.17 | 0.567 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.564 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.564 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.563 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.557 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.556 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.556 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.554 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.553 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.551 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.550 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.547 | |
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 | 0.545 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.544 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.544 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.542 | |
| 4gql | R47 | Macrophage metalloelastase | 3.4.24.65 | 0.539 | |
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 0.536 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.533 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.533 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.531 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.530 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.529 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.529 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.528 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.528 | |
| 1d8m | BBH | Stromelysin-1 | 3.4.24.17 | 0.524 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.523 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.516 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.514 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.512 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.512 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.512 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.511 | |
| 2w0d | CGS | Macrophage metalloelastase | 3.4.24.65 | 0.509 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.509 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.507 | |
| 3oho | Z79 | Stromelysin-1 | 3.4.24.17 | 0.506 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.502 | |
| 1d5j | MM3 | Stromelysin-1 | 3.4.24.17 | 0.502 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.502 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.501 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.500 | |
| 2woa | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.500 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.497 | |
| 2wo8 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.497 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.495 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.494 | |
| 3kek | 3EK | Collagenase 3 | 3.4.24 | 0.492 | |
| 1biw | S80 | Stromelysin-1 | 3.4.24.17 | 0.491 | |
| 1xuc | PB3 | Collagenase 3 | 3.4.24 | 0.491 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.490 | |
| 2ow2 | 8MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.488 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.488 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.479 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.475 | |
| 1xud | PB4 | Collagenase 3 | 3.4.24 | 0.471 | |
| 2wo9 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.471 | |
| 1gkc | NFH | Matrix metalloproteinase-9 | 3.4.24.35 | 0.470 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.470 | |
| 2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.461 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.454 | |
| 1mnc | PLH | Neutrophil collagenase | 3.4.24.34 | 0.450 | |
| 2ow9 | SP6 | Collagenase 3 | 3.4.24 | 0.449 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.447 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.445 | |
| 1fm1 | WAY | Collagenase 3 | 3.4.24 | 0.443 | |
| 1hov | I52 | 72 kDa type IV collagenase | 3.4.24.24 | 0.443 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.441 |