scPDB - Distribution of Cavity Similarity values of 1cd2 entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1cd2	FOL	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	1.000
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.680
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.641
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.614
3qlx	QLR	Uncharacterized protein	/	0.600
3cse	N22	Uncharacterized protein	/	0.595
3qly	55V	Uncharacterized protein	/	0.578
3eek	53S	Uncharacterized protein	/	0.574
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.573
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.570
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.569
4h98	14Q	Uncharacterized protein	/	0.569
3eem	53V	Uncharacterized protein	/	0.566
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.566
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.566
3eej	53R	Uncharacterized protein	/	0.565
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.562
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.561
3eel	53T	Uncharacterized protein	/	0.558
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.553
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.551
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.550
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.549
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.545
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.544
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.541
3qlz	QLZ	Uncharacterized protein	/	0.538
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.536
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.535
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.535
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.525
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.523
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.518
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.518
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.514
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.512
3ia4	MTX	Dihydrofolate reductase	/	0.510
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.506
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.505
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.505
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.504
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.503
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.501
2w3v	TOP	Dihydrofolate reductase	/	0.501
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.499
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.498
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.497
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.497
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.496
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.495
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.495
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.495
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.494
3inv	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.493
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.493
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.493
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.493
3jwc	EKB	Dihydrofolate reductase	/	0.492
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.490
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.490
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.490
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.489
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.488
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.487
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.486
3dga	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.485
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.484
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.484
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.482
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.481
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.481
2zza	FOL	Dihydrofolate reductase	/	0.479
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.479
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.477
3tqb	FOL	Dihydrofolate reductase	/	0.475
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.473
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.471
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.471
3kjs	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.471
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.471
3tq9	MTX	Dihydrofolate reductase	/	0.470
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.470
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.470
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.469
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.467
3sa1	6DR	Dihydrofolate reductase	/	0.467
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.467
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.466
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.465
4ele	31I	Dihydrofolate reductase	/	0.464
4elb	34S	Dihydrofolate reductase	/	0.463
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.461
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.461
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.460
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.460
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.458
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.457
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.457
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.457
1kzj	CB3	Thymidylate synthase	/	0.455
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.454
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
3sa2	7DR	Dihydrofolate reductase	/	0.452
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.451
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.451
3sai	9DR	Dihydrofolate reductase	/	0.451
2z3u	CRR	Cytochrome P450	/	0.450
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.450
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.449
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.449
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.448
1og5	SWF	Cytochrome P450 2C9	/	0.448
2w3w	VG9	Dihydrofolate reductase	/	0.448
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.448
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.447
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.445
3jwm	5WB	Dihydrofolate reductase	/	0.445
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.445
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.444
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.444
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.443
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.443
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.441
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.440
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.440
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.440
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.440