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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1bzfTMQDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1bzfTMQDihydrofolate reductase1.5.1.31.000
1disBDMDihydrofolate reductase1.5.1.30.494
1diuBDMDihydrofolate reductase1.5.1.30.492
1ddsMTXDihydrofolate reductase1.5.1.30.469
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
1dhfFOLDihydrofolate reductase1.5.1.30.459
1re7FOLDihydrofolate reductase1.5.1.30.453
2cig1DGDihydrofolate reductase1.5.1.30.449
1rb3MTXDihydrofolate reductase1.5.1.30.448
4cd2FOLDihydrofolate reductase1.5.1.30.447
1ddrMTXDihydrofolate reductase1.5.1.30.446
2drcMTXDihydrofolate reductase1.5.1.30.443
1ao8MTXDihydrofolate reductase1.5.1.30.442
2dhfDZFDihydrofolate reductase1.5.1.30.442
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.442
1ia3TQ5Dihydrofolate reductase1.5.1.30.441
1dr3TAPDihydrofolate reductase1.5.1.30.440
1draMTXDihydrofolate reductase1.5.1.30.440
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440