sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.864 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.837 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.810 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.804 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.798 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.791 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.768 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.763 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.762 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.758 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.746 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.737 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.729 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.725 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.724 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.717 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.716 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.716 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.716 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.712 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.706 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.706 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.704 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.698 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.697 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.695 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.694 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.692 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.690 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.679 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.676 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.676 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.672 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.670 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.670 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.669 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.668 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.667 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.663 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.663 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.662 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.661 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.660 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.655 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.655 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.653 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.653 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.653 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.649 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.649 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.647 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.646 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.646 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.641 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.641 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.641 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.638 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.638 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.636 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.635 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.635 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.633 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.628 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.628 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.626 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.626 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.622 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.618 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.609 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.608 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.607 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.599 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.596 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.596 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.587 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.581 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.577 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.577 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.569 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.568 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.565 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.560 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.554 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.552 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.549 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.549 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.548 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.546 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.544 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.544 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.540 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.534 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.529 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.528 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.527 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.526 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.526 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.522 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.519 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.515 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.512 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.512 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.512 | |
| 4knn | E1F | Carbonic anhydrase 13 | 4.2.1.1 | 0.503 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.502 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.496 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.490 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.488 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.488 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.487 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.486 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.486 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.485 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.484 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.483 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.483 | |
| 3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.483 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.482 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.481 | |
| 2a84 | ATP | Pantothenate synthetase | 6.3.2.1 | 0.480 | |
| 5fl4 | 9FK | Carbonic anhydrase 9 | 4.2.1.1 | 0.478 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.475 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.475 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.474 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.474 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.473 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.473 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.472 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.470 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.470 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.468 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.468 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.467 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.467 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.467 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.466 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.466 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.465 | |
| 1c9w | NAP | Aldose reductase-related protein 2 | / | 0.464 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.464 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.464 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.464 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.464 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.463 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.463 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.463 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.463 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.462 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.462 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.461 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.461 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.461 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.460 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.460 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.460 | |
| 1q51 | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.459 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3a6r | FMN | FMN-binding protein | / | 0.459 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.459 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.458 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.458 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.458 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.457 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.457 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.457 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.457 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.456 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.456 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.455 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.455 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.455 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.455 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 4iae | 1DX | Alr2278 protein | / | 0.455 | |
| 1c7o | PPG | Hemolysin | / | 0.454 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.454 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.453 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.453 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.453 | |
| 4iah | 1DX | Alr2278 protein | / | 0.453 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.453 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.452 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.452 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.452 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.452 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.452 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1po7 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.451 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.451 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.451 | |
| 3v2u | ATP | Protein GAL3 | / | 0.451 | |
| 4c1e | MCO | Beta-lactamase class B VIM-2 | / | 0.451 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.451 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.450 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.450 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.450 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.450 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.450 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.450 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.450 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.450 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.449 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.449 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.449 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.449 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.449 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.449 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.449 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.449 | |
| 5d5b | CAU | Beta-2 adrenergic receptor | / | 0.449 | |
| 2e1m | FAD | L-glutamate oxidase | / | 0.448 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.448 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.448 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.448 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.448 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.448 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.447 | |
| 3ksq | Z96 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.447 | |
| 4jic | FMN | GTN Reductase | / | 0.447 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.446 | |
| 1o1s | 1NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.446 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.446 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.446 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.446 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.446 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 1s4p | GDP | Glycolipid 2-alpha-mannosyltransferase | / | 0.445 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.445 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.445 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.445 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.445 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.445 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.445 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.445 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.444 | |
| 1bdm | NAX | Malate dehydrogenase | / | 0.444 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.444 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.444 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.444 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.444 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.444 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.444 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 4rr6 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.444 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.444 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.443 | |
| 1efa | NPF | Lactose operon repressor | / | 0.443 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.443 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 1til | ATP | Anti-sigma F factor | / | 0.443 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.443 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.443 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.443 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.443 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.443 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.443 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.443 | |
| 4tyq | AP5 | Adenylate kinase | / | 0.443 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.443 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.442 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.442 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.442 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.442 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.442 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.442 | |
| 3a6q | FMN | FMN-binding protein | / | 0.442 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4boe | CLR | Japanin | / | 0.442 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.442 | |
| 4n1g | CEI | Obelin | / | 0.442 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.442 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.442 | |
| 1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.441 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.441 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.441 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.441 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.441 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.441 | |
| 3wag | TYD | Glycosyltransferase | / | 0.441 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.441 | |
| 4m11 | MXM | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.441 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.441 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.441 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.440 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.440 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1s64 | 778 | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.440 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.440 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.440 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.440 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.440 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.440 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.440 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.440 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.440 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.440 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.440 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.440 |