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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1az1ALRAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1az1ALRAldose reductase1.1.1.211.000
2nvdITBAldose reductase1.1.1.210.519
1pwmFIDAldose reductase1.1.1.210.472
3s3vTOPDihydrofolate reductase1.5.1.30.460
3n0hTOPDihydrofolate reductase1.5.1.30.459
1s3uTQDDihydrofolate reductase1.5.1.30.457
2aclL05Oxysterols receptor LXR-alpha/0.442