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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1axwMTXThymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1axwMTXThymidylate synthase/1.000
1jtqLY3Thymidylate synthase/0.669
1dnaCB3Thymidylate synthase/0.614
1kceCB3Thymidylate synthase/0.571
1fwmCB3Thymidylate synthase/0.553
1aiqCB3Thymidylate synthase/0.550
1dduCB3Thymidylate synthase/0.546
1tduCB3Thymidylate synthase/0.535
1zprCB3Thymidylate synthase/0.527
2bbqPFGThymidylate synthase/0.527
1tsdF89Thymidylate synthase/0.526
1trgCB3Thymidylate synthase/0.525
1kzjCB3Thymidylate synthase/0.519
2ftoCB3Thymidylate synthase/0.508
1nceCB3Thymidylate synthase/0.505
2tscCB3Thymidylate synthase/0.505
1jtuLYBThymidylate synthase/0.502
3bgxMEFThymidylate synthase/0.498
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.496
1ju6LYAThymidylate synthase2.1.1.450.494
1tysDHFThymidylate synthase/0.493
4fqsLYAThymidylate synthase ThyA/0.491
1kziTHGThymidylate synthase/0.486
1bq1CB3Thymidylate synthase/0.484
4gevCB3Thymidylate synthase/0.483
1jutLYDThymidylate synthase/0.482
4foxD16Thymidylate synthase ThyA/0.481
1dduDDUThymidylate synthase/0.474
1hvyD16Thymidylate synthase2.1.1.450.473
4knzCB3Thymidylate synthase/0.473
1an5CB3Thymidylate synthase/0.470
1synF89Thymidylate synthase/0.470
3uwlFOZThymidylate synthase/0.467
1tduDURThymidylate synthase/0.465
1f4fTP3Thymidylate synthase/0.461
4ez8DHFThymidylate synthase2.1.1.450.460
3bhlTHGThymidylate synthase/0.459
1jujLYAThymidylate synthase2.1.1.450.456
2kceD16Thymidylate synthase/0.455
1ci7CB3Thymidylate synthase2.1.1.450.451
1f28F89Thymidylate synthase2.1.1.450.449
3bhrTHGThymidylate synthase/0.448
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
4o7uTHFThymidylate synthase/0.442