sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ahb | FMP | Ribosome-inactivating protein momordin I | 3.2.2.22 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1ahb | FMP | Ribosome-inactivating protein momordin I | 3.2.2.22 | 1.000 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.526 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.509 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.508 | |
| 1lpc | CMP | Antiviral protein DAP-30 | 3.2.2.22 | 0.508 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.503 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.502 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.501 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.501 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.500 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.500 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.499 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.498 | |
| 3w3n | RX8 | Toll-like receptor 8 | / | 0.496 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.496 | |
| 5ilw | URI | Ribosome inactivating protein | / | 0.496 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.495 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.495 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.495 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.494 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.494 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.492 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.491 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.491 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.490 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.490 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.489 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.489 | |
| 2oad | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.488 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.487 | |
| 2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.486 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.485 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.485 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.484 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.484 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.483 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.483 | |
| 3nt2 | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.483 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.482 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.482 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 4emr | MGP | Ribosome inactivating protein | / | 0.482 | |
| 4rel | KMP | Glycosyltransferase | / | 0.482 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 4c72 | TLG | 3-oxoacyl-ACP synthase | / | 0.481 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.481 | |
| 4nv1 | TYD | Formyl transferase | / | 0.481 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.481 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.480 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.480 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.479 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.478 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.478 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.478 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.478 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.477 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.477 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.477 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.476 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.476 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.476 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.475 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.475 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.475 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.475 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.475 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.475 | |
| 4l0o | PLP | Cystathionine gamma-synthase | 2.5.1.48 | 0.475 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.474 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.474 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.474 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.474 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.473 | |
| 1x2e | ATX | Proline iminopeptidase | 3.4.11.5 | 0.473 | |
| 2c9b | PUG | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 2p98 | YE7 | Methionine aminopeptidase | / | 0.473 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.473 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.473 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.473 | |
| 1jsz | NDM | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | 2.1.1.57 | 0.472 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.472 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.472 | |
| 1wuq | 8GT | GTP cyclohydrolase 1 | / | 0.472 | |
| 4yao | 2AM | NADPH--cytochrome P450 reductase | / | 0.472 | |
| 3nya | JTZ | Beta-2 adrenergic receptor | / | 0.472 | |
| 1b8o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.471 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.471 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.471 | |
| 1e6z | NGO | Chitinase | / | 0.470 | |
| 1mrk | FMC | Ribosome-inactivating protein alpha-trichosanthin | 3.2.2.22 | 0.470 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.470 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.470 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.470 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.470 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.470 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.470 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.469 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.469 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.469 | |
| 3c1o | NAP | Eugenol synthase | / | 0.469 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.469 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.469 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.469 | |
| 4jbx | SK7 | Thymidine kinase | / | 0.469 | |
| 4jtp | ASC | Ribosome inactivating protein | / | 0.469 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.469 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.468 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.468 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.468 | |
| 2oac | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.468 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.468 | |
| 3o76 | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.468 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.468 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.467 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.467 | |
| 2fb3 | 5AD | GTP 3',8-cyclase | 4.1.99.18 | 0.467 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.467 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.467 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.467 | |
| 4itx | IN5 | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.467 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.467 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.467 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.466 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.466 | |
| 3g11 | P9C | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.466 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.466 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.466 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.466 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4kmz | FOL | Folate receptor beta | / | 0.466 | |
| 4xmx | BES | Aminopeptidase N | 3.4.11.2 | 0.466 | |
| 1m2x | MCO | Metallo-beta-lactamase type 2 | / | 0.465 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.465 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.465 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.465 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.465 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.465 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.465 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.465 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.464 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.464 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 3zmg | 6Z0 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.464 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.464 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.463 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.463 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.463 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.463 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3p9t | TCL | Repressor | / | 0.463 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.463 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.462 | |
| 1cq6 | PY4 | Aspartate aminotransferase | 2.6.1.1 | 0.462 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.462 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.462 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.462 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 3hgg | CHD | CmeR | / | 0.462 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.462 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.462 | |
| 3zov | WZV | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4jv3 | N32 | Beta-ketoacyl synthase | / | 0.462 | |
| 1e2n | RCA | Thymidine kinase | / | 0.461 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.461 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 2po3 | T4K | 4-dehydrase | / | 0.461 | |
| 3hiv | TXN | rRNA N-glycosidase | / | 0.461 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.461 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.461 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.461 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.460 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.460 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.460 | |
| 1ve7 | 4NP | Acylamino-acid-releasing enzyme | 3.4.19.1 | 0.460 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.460 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.460 | |
| 2wea | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.460 | |
| 3dz7 | O8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.460 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.460 | |
| 3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.460 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.460 | |
| 1el4 | CTZ | Obelin | / | 0.459 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.459 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.459 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.459 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.459 | |
| 3w3l | RX8 | Toll-like receptor 8 | / | 0.459 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.459 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.458 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.458 | |
| 1po7 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.458 | |
| 1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.458 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.458 | |
| 2hej | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.458 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.458 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3lut | NAP | Voltage-gated potassium channel subunit beta-2 | / | 0.458 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4azw | SAM | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.458 | |
| 4j7h | TRH | PCZA361.3 | / | 0.458 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.458 | |
| 4xcz | T3Q | Qdtf | / | 0.458 | |
| 1dia | L24 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.457 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.457 | |
| 1tiq | COA | Spermidine/spermine N(1)-acetyltransferase | / | 0.457 | |
| 1xnz | FCD | Methionine aminopeptidase | / | 0.457 | |
| 2r6k | GTX | Glutathione S-transferase A1 | 2.5.1.18 | 0.457 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.457 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.457 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.457 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.457 | |
| 4br3 | U85 | Choline kinase alpha | 2.7.1.32 | 0.457 | |
| 4da5 | 0H7 | Choline kinase alpha | 2.7.1.32 | 0.457 | |
| 4je5 | PLP | Aromatic/aminoadipate aminotransferase 1 | 2.6.1.39 | 0.457 | |
| 1e2j | THM | Thymidine kinase | / | 0.456 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.456 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.456 | |
| 2bd0 | BIO | Sepiapterin reductase | / | 0.456 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.456 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.456 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.456 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.456 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.456 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.456 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.456 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.456 | |
| 4ise | 1FW | Glucokinase | 2.7.1.2 | 0.456 | |
| 4j0y | 1H6 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.456 | |
| 1tkb | N1T | Transketolase 1 | 2.2.1.1 | 0.455 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.455 | |
| 1wsb | FMN | Flavodoxin | / | 0.455 | |
| 1x2b | STX | Proline iminopeptidase | 3.4.11.5 | 0.455 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.455 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.455 | |
| 2wzm | NA7 | Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346 | / | 0.455 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3b4p | 3B4 | Phenazine biosynthesis protein A/B | / | 0.455 | |
| 3n76 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.455 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.455 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.455 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.455 | |
| 4iku | SHX | Methionine aminopeptidase 1 | / | 0.455 | |
| 4mx1 | 1MX | Ricin | 3.2.2.22 | 0.455 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.455 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.455 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.455 | |
| 1i75 | NOJ | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.454 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.454 | |
| 1sdw | IYT | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.454 | |
| 1swg | BTN | Streptavidin | / | 0.454 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.454 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.454 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2ejz | SAH | Diphthine synthase | / | 0.454 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.454 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.454 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.454 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.454 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.454 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.454 | |
| 4bfd | 8T3 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.454 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.454 | |
| 4qfz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.454 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.454 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.454 | |
| 1by5 | GLY_GLY_GLY_AHO_AHO_AHO_FE | Ferrichrome-iron receptor | / | 0.453 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 1ifu | FMC | Ricin | 3.2.2.22 | 0.453 | |
| 1lgt | BP3 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.453 | |
| 1mra | APG | Mandelate racemase | / | 0.453 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.453 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.453 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.453 | |
| 2gou | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.453 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.453 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.453 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.453 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.453 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.453 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.453 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.453 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4ai8 | DZA | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.453 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.453 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.453 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.453 | |
| 1asc | NPL | Aspartate aminotransferase | 2.6.1.1 | 0.452 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.452 | |
| 1w19 | T4P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 2avx | HTF | Regulatory protein SdiA | / | 0.452 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.452 | |
| 2xda | JPS | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.452 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.452 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.452 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 4fli | Y16 | Methionine aminopeptidase 1 | / | 0.452 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 1n5v | NOM | ActVA 6 protein | / | 0.451 | |
| 1w35 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.451 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.451 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3lzz | GDP | Uncharacterized protein | / | 0.451 | |
| 4lh7 | 1X8 | DNA ligase | / | 0.451 | |
| 4mfe | BTN | Pyruvate carboxylase | / | 0.451 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.451 | |
| 5dp2 | NAP | CurF | / | 0.451 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.450 | |
| 1pua | COA | HAT A1 | / | 0.450 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.450 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.450 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.450 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.450 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.450 | |
| 3mvz | BHN | Nickel-binding periplasmic protein | / | 0.450 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.450 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.450 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.450 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4drk | I63 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.450 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.450 | |
| 4g5d | NDP | Prostaglandin F synthase | 1.1.1.188 | 0.450 | |
| 4j0p | 1H8 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.450 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.449 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.449 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1vfs | DCS | Alanine racemase | / | 0.449 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.449 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.449 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.449 | |
| 3ccb | B2Y | Dipeptidyl peptidase 4 | / | 0.449 | |
| 3e4v | FMN | Uncharacterized protein | / | 0.449 | |
| 3frk | TQP | QdtB | / | 0.449 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.449 | |
| 3mo0 | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.449 | |
| 3ssm | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.449 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.449 | |
| 4dxl | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.449 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.448 | |
| 1hlk | 113 | Metallo-beta-lactamase type 2 | / | 0.448 | |
| 1j8q | FMN | Flavodoxin | / | 0.448 | |
| 1s36 | CEI | Obelin | / | 0.448 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.448 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.448 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.448 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3dzj | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.448 | |
| 3ele | PLP | Aminotransferase | / | 0.448 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.448 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.448 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.448 | |
| 4dlc | UMP | Deoxyuridine triphosphatase, putative | / | 0.448 | |
| 4drn | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.448 | |
| 4gm4 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.448 | |
| 4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.448 | |
| 4v0s | 2HN | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.448 | |
| 1a4l | DCF | Adenosine deaminase | 3.5.4.4 | 0.447 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.447 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.447 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 2c6c | 24I | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.447 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.447 | |
| 2clm | F6F | Tryptophan synthase alpha chain | / | 0.447 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.447 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.447 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.447 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.447 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.447 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.447 | |
| 3v0m | 5GW | Histo-blood group ABO system transferase | / | 0.447 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.447 | |
| 4d03 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 4flj | Y08 | Methionine aminopeptidase 1 | / | 0.447 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.447 | |
| 4lrr | CF9 | Thymidylate synthase | / | 0.447 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.447 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.447 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1qru | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.446 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.446 | |
| 2r8o | T5X | Transketolase 1 | / | 0.446 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.446 | |
| 3ei8 | PL5 | LL-diaminopimelate aminotransferase, chloroplastic | / | 0.446 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.446 | |
| 3kaq | FMN | Flavodoxin | / | 0.446 | |
| 3mbg | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.446 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 1i7m | CG | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.445 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.445 | |
| 2aly | YSA | Phenylalanine--tRNA ligase alpha subunit | 6.1.1.20 | 0.445 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2vqj | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.445 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.445 | |
| 3c0z | SHH | Histone deacetylase 7 | 3.5.1.98 | 0.445 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.445 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.445 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4k30 | NLG | N-acetylglutamate synthase, mitochondrial | 2.3.1.1 | 0.445 | |
| 4mbs | MRV | C-C chemokine receptor type 5 | / | 0.445 | |
| 4nhy | PD2 | Prolyl 3-hydroxylase OGFOD1 | 1.14.11 | 0.445 | |
| 5ewk | P34 | Putative secreted protein | / | 0.445 | |
| 5jdz | SAH | Methyl transferase | / | 0.445 | |
| 1aqv | 0HG | Glutathione S-transferase P | 2.5.1.18 | 0.444 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.444 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.444 | |
| 1gm8 | SOX | Penicillin G acylase | 3.5.1.11 | 0.444 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.444 | |
| 1pwu | GM6 | Lethal factor | 3.4.24.83 | 0.444 | |
| 1rxj | BNI | Streptavidin | / | 0.444 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2tpl | HPP | Tyrosine phenol-lyase | 4.1.99.2 | 0.444 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.444 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.444 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3pch | CHB | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.444 | |
| 3w5u | FAD | Ferredoxin | / | 0.444 | |
| 4ba5 | PXG | Probable aminotransferase | / | 0.444 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4lng | JAN | CaaX farnesyltransferase beta subunit Ram1 | / | 0.444 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 4to0 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ej3 | CZH | Aequorin-2 | / | 0.443 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.443 | |
| 2glr | GTX | Glutathione S-transferase P 1 | 2.5.1.18 | 0.443 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.443 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2wgs | 1AZ | Glutamine synthetase | 6.3.1.2 | 0.443 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.443 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.443 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 3ntr | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.443 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.443 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.443 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.443 | |
| 3p8h | P8H | Lethal(3)malignant brain tumor-like protein 1 | / | 0.443 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.443 | |
| 3v2u | ATP | Protein GAL3 | / | 0.443 | |
| 4b1h | AR6 | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.443 | |
| 4e31 | JHZ | Methyltransferase | / | 0.443 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.443 | |
| 4iif | CTS | Beta-glucosidase 1 | 3.2.1.21 | 0.443 | |
| 4j1c | 1HO | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.443 | |
| 1az2 | NAP | Aldose reductase | 1.1.1.21 | 0.442 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.442 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.442 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.442 | |
| 1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.442 | |
| 1til | ATP | Anti-sigma F factor | / | 0.442 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2r5n | TPP | Transketolase 1 | / | 0.442 | |
| 2zit | NAD | Exotoxin A | 2.4.2.36 | 0.442 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.442 | |
| 3csj | CBL | Glutathione S-transferase P | 2.5.1.18 | 0.442 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.442 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.442 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.442 | |
| 3g6z | A7T | Renin | 3.4.23.15 | 0.442 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.442 | |
| 3ipk | PMS | Surface protein adhesin | / | 0.442 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.442 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.442 | |
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 0.442 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.442 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4qfx | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.442 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.442 | |
| 4rtb | SAM | Putative thiazole biosynthesis protein ThiH | / | 0.442 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.442 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.441 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.441 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.441 | |
| 1uhh | CZP | Aequorin-2 | / | 0.441 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.441 | |
| 2pgt | GPR | Glutathione S-transferase P | 2.5.1.18 | 0.441 | |
| 2q3o | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.441 | |
| 2xnp | WCX | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.441 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.441 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4gg1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.441 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.441 | |
| 4to2 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.441 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.441 | |
| 1ahg | TYR_PLP | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1fdk | GLE | Phospholipase A2 | 3.1.1.4 | 0.440 | |
| 1jf0 | CZH | Obelin | / | 0.440 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.440 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 1xry | BES | Bacterial leucyl aminopeptidase | 3.4.11.10 | 0.440 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 2v8p | CDP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.440 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.440 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.440 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.440 | |
| 3gc4 | AAQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 3h0w | N8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.440 | |
| 3h7u | NAP | NADPH-dependent aldo-keto reductase, chloroplastic | / | 0.440 | |
| 3jqr | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.440 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3pft | FMN | Flavin reductase | / | 0.440 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.440 | |
| 3pzc | GAP | Amino acid--[acyl-carrier-protein] ligase 1 | 6.2.1.n2 | 0.440 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.440 | |
| 4d6q | PD2 | Lysine-specific demethylase 4D | 1.14.11 | 0.440 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.440 |