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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1a42BZUCarbonic anhydrase 24.2.1.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1a42BZUCarbonic anhydrase 24.2.1.11.000
1bnnAL1Carbonic anhydrase 24.2.1.10.773
3dazMZMCarbonic anhydrase 24.2.1.10.737
1bn1AL5Carbonic anhydrase 24.2.1.10.735
2h15B19Carbonic anhydrase 24.2.1.10.727
1bn4AL9Carbonic anhydrase 24.2.1.10.721
1bnwTPDCarbonic anhydrase 24.2.1.10.708
1bntAL2Carbonic anhydrase 24.2.1.10.706
3k2fNKXCarbonic anhydrase 24.2.1.10.705
1i91INQCarbonic anhydrase 24.2.1.10.701
3d9zD9ZCarbonic anhydrase 24.2.1.10.698
3eft3BSCarbonic anhydrase 24.2.1.10.686
1i9nIOACarbonic anhydrase 24.2.1.10.684
1i9mINWCarbonic anhydrase 24.2.1.10.676
1kwrSG2Carbonic anhydrase 24.2.1.10.672
1cilETSCarbonic anhydrase 24.2.1.10.663
3dc3AZMCarbonic anhydrase 24.2.1.10.661
1bnqAL4Carbonic anhydrase 24.2.1.10.657
1if6FBUCarbonic anhydrase 24.2.1.10.657
3m5eJDRCarbonic anhydrase 24.2.1.10.655
2eu3FF3Carbonic anhydrase 24.2.1.10.651
1i90INMCarbonic anhydrase 24.2.1.10.649
1g52F2BCarbonic anhydrase 24.2.1.10.648
1if4FBSCarbonic anhydrase 24.2.1.10.647
3d8wD8WCarbonic anhydrase 24.2.1.10.641
3po6DT9Carbonic anhydrase 24.2.1.10.640
1zsbAZMCarbonic anhydrase 24.2.1.10.638
3qykIE2Carbonic anhydrase 24.2.1.10.638
4kap1QVCarbonic anhydrase 24.2.1.10.638
1g4oBSBCarbonic anhydrase 24.2.1.10.636
3sbhE65Carbonic anhydrase 24.2.1.10.636
3v2jAZMCarbonic anhydrase 24.2.1.10.633
1bn3AL6Carbonic anhydrase 24.2.1.10.631
3b4fTUOCarbonic anhydrase 24.2.1.10.630
1if5FBTCarbonic anhydrase 24.2.1.10.625
3mhoJ43Carbonic anhydrase 24.2.1.10.621
1bnuAL3Carbonic anhydrase 24.2.1.10.620
1g4jFFBCarbonic anhydrase 24.2.1.10.620
3betCTFCarbonic anhydrase 24.2.1.10.619
4itoMPXCarbonic anhydrase 24.2.1.10.617
1xpz4TZCarbonic anhydrase 24.2.1.10.616
1bnmAL8Carbonic anhydrase 24.2.1.10.613
4bf6X0QCarbonic anhydrase 24.2.1.10.609
3dd82C7Carbonic anhydrase 24.2.1.10.607
4ilx1EZCarbonic anhydrase 24.2.1.10.602
1kwqSG1Carbonic anhydrase 24.2.1.10.601
1ttm667Carbonic anhydrase 24.2.1.10.598
2wehFB1Carbonic anhydrase 24.2.1.10.598
3dcsMZMCarbonic anhydrase 24.2.1.10.597
3mhlJ71Carbonic anhydrase 24.2.1.10.597
4m2rBZ1Carbonic anhydrase 24.2.1.10.596
1cnwEG1Carbonic anhydrase 24.2.1.10.590
3m67E36Carbonic anhydrase 24.2.1.10.587
3n4bWWZCarbonic anhydrase 24.2.1.10.587
2h4nAZMCarbonic anhydrase 24.2.1.10.585
3ni5C1HCarbonic anhydrase 24.2.1.10.584
3hkuTORCarbonic anhydrase 24.2.1.10.583
1i8zINLCarbonic anhydrase 24.2.1.10.582
2wejFB2Carbonic anhydrase 24.2.1.10.581
3igpDT7Carbonic anhydrase 24.2.1.10.579
1bnvAL7Carbonic anhydrase 24.2.1.10.578
1if7SBRCarbonic anhydrase 24.2.1.10.578
3ml2SU0Carbonic anhydrase 24.2.1.10.576
3m2yBE0Carbonic anhydrase 24.2.1.10.575
4kniE1ECarbonic anhydrase 24.2.1.10.573
3dccD9ZCarbonic anhydrase 24.2.1.10.572
4n16CHDCarbonic anhydrase 24.2.1.10.569
3n2pAYXCarbonic anhydrase 24.2.1.10.567
4itp1GDCarbonic anhydrase 24.2.1.10.566
1g45FSBCarbonic anhydrase 24.2.1.10.565
2x7tWZBCarbonic anhydrase 24.2.1.10.565
3mzcS6ICarbonic anhydrase 24.2.1.10.565
4k13ETSCarbonic anhydrase 24.2.1.10.565
3kigDA4Carbonic anhydrase 24.2.1.10.563
2weoFBWCarbonic anhydrase 24.2.1.10.561
1cnxEG2Carbonic anhydrase 24.2.1.10.560
3ffpLC1Carbonic anhydrase 24.2.1.10.558
3p5lIT5Carbonic anhydrase 24.2.1.10.558
3bl1BL1Carbonic anhydrase 24.2.1.10.556
3mnaDWHCarbonic anhydrase 24.2.1.10.555
4m2vBZ1Carbonic anhydrase 24.2.1.10.555
4mo82VQCarbonic anhydrase 24.2.1.10.553
3t84SG6Carbonic anhydrase 24.2.1.10.552
1okmSABCarbonic anhydrase 24.2.1.10.551
1cnyEG3Carbonic anhydrase 24.2.1.10.549
1i9pIOECarbonic anhydrase 24.2.1.10.549
5fltVJJCarbonic anhydrase 24.2.1.10.546
3oysOYSCarbonic anhydrase 24.2.1.10.543
3oyqOYQCarbonic anhydrase 24.2.1.10.540
4pxxCHDCarbonic anhydrase 24.2.1.10.539
3n0nP9BCarbonic anhydrase 24.2.1.10.538
2wd2MS5Carbonic anhydrase 24.2.1.10.536
3dbuD8WCarbonic anhydrase 24.2.1.10.536
4ht2V50Carbonic anhydrase 124.2.1.10.535
3mdzEZLCarbonic anhydrase 74.2.1.10.534
3oikWZBCarbonic anhydrase 24.2.1.10.533
3mhcARZCarbonic anhydrase 24.2.1.10.531
1oklMNSCarbonic anhydrase 24.2.1.10.530
2x7uWZACarbonic anhydrase 24.2.1.10.528
3oimVZ5Carbonic anhydrase 24.2.1.10.527
3oy0OY0Carbonic anhydrase 24.2.1.10.527
3s8xE59Carbonic anhydrase 24.2.1.10.526
3saxE50Carbonic anhydrase 24.2.1.10.526
2q1qOSPCarbonic anhydrase 24.2.1.10.522
1jd0AZMCarbonic anhydrase 124.2.1.10.520
4bf19FKCarbonic anhydrase 24.2.1.10.518
1eouSMSCarbonic anhydrase 24.2.1.10.515
3dcwEZLCarbonic anhydrase 24.2.1.10.513
3sbiE90Carbonic anhydrase 24.2.1.10.511
4kp8E1GCarbonic anhydrase 124.2.1.10.510
4kp5E1FCarbonic anhydrase 124.2.1.10.508
3f7bAG5Carbonic anhydrase 44.2.1.10.504
3nb5R21Carbonic anhydrase 24.2.1.10.504
3fw3ETSCarbonic anhydrase 44.2.1.10.501
3rz8RZ8Carbonic anhydrase 24.2.1.10.500
4xiwAZMCarbonic anhydrase, alpha type/0.500
3f7uAG4Carbonic anhydrase 44.2.1.10.496
3l14I7BCarbonic anhydrase 24.2.1.10.496
3zncBZ1Carbonic anhydrase 44.2.1.10.496
1i9qIOFCarbonic anhydrase 24.2.1.10.492
1if8SBSCarbonic anhydrase 24.2.1.10.491
3mhiJ90Carbonic anhydrase 24.2.1.10.488
3t82SG4Carbonic anhydrase 24.2.1.10.487
2powI7CCarbonic anhydrase 24.2.1.10.486
3m96E38Carbonic anhydrase 24.2.1.10.486
1oknSTBCarbonic anhydrase 24.2.1.10.480
4knmE1ECarbonic anhydrase 134.2.1.10.480
4lu3AZMCarbonic anhydrase 144.2.1.10.480
4k0zMZMCarbonic anhydrase 24.2.1.10.476
1g54FFBCarbonic anhydrase 24.2.1.10.475
4knjE1FCarbonic anhydrase 24.2.1.10.474
1oq5CELCarbonic anhydrase 24.2.1.10.472
4k0tD9ZCarbonic anhydrase 24.2.1.10.470
4dz7D02Carbonic anhydrase 24.2.1.10.469
3rsv3RSBeta-secretase 13.4.23.460.468
4nvk2NYPeroxidase/0.468
1xe65FPPlasmepsin-23.4.23.390.466
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.465
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.463
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.460
3s3vTOPDihydrofolate reductase1.5.1.30.460
3e8xNAPBH1520 protein/0.458
3h3r14HCollagen type IV alpha-3-binding protein/0.458
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.458
1ydaAZMCarbonic anhydrase 24.2.1.10.457
3t85SG7Carbonic anhydrase 24.2.1.10.456
3qsaTA7Anthranilate phosphoribosyltransferase/0.455
1w6hTITPlasmepsin-23.4.23.390.454
2a92NAIL-lactate dehydrogenase/0.453
4yp6NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.453
4bftZVTPantothenate kinase2.7.1.330.451
4giu636Anthranilate phosphoribosyltransferase/0.451
2cy0NAPShikimate dehydrogenase (NADP(+))/0.450
4eb5PLPCysteine desulfurase IscS 2/0.450
4knnE1FCarbonic anhydrase 134.2.1.10.450
3dd0EZLCarbonic anhydrase 24.2.1.10.448
2rqfJH3Hemolymph juvenile hormone binding protein/0.447
4a87NARMajor pollen allergen Bet v 1-A/0.447
1vi2NADQuinate/shikimate dehydrogenase/0.446
1x1dSAHC-20 methyltransferase/0.446
2qimZEAClass 10 plant pathogenesis-related protein/0.446
3p62FMNPentaerythritol tetranitrate reductase/0.446
3jyqNADQuinate/shikimate dehydrogenase (NAD(+))/0.445
3oadLPORenin3.4.23.150.445
4a83DXCMajor pollen allergen Bet v 1-A/0.445
1xddAAYIntegrin alpha-L/0.444
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.444
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.443
4bfvZVVPantothenate kinase2.7.1.330.443
4hu1V13Carbonic anhydrase 134.2.1.10.443
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.442
3ziuLSSLeucyl-tRNA synthetase/0.442
4bfzZVZPantothenate kinase2.7.1.330.442
1x1bSAHC-20 methyltransferase/0.441
1bwsNDPGDP-L-fucose synthase/0.440
1h50FMNPentaerythritol tetranitrate reductase/0.440
1q51CAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.440