sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1a2b | GSP | Transforming protein RhoA |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1a2b | GSP | Transforming protein RhoA | / | 1.000 | |
| 2gcp | GSP | Rho-related GTP-binding protein RhoC | / | 0.611 | |
| 1kmq | GNP | Transforming protein RhoA | / | 0.596 | |
| 1cxz | GSP | Transforming protein RhoA | / | 0.595 | |
| 1m7b | GTP | Rho-related GTP-binding protein RhoE | / | 0.589 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.576 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.568 | |
| 4js0 | GNP | Cell division control protein 42 homolog | / | 0.568 | |
| 3a58 | GNP | GTP-binding protein RHO1 | / | 0.553 | |
| 3kz1 | GSP | Transforming protein RhoA | / | 0.548 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.547 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.544 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.543 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.538 | |
| 4mit | GTP | Rho-related protein racC | / | 0.537 | |
| 3eg5 | GNP | Cell division control protein 42 homolog | / | 0.534 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.533 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.525 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.523 | |
| 2rge | GNP | GTPase HRas | / | 0.520 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.518 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.517 | |
| 5hpy | GDP | Transforming protein RhoA | / | 0.516 | |
| 3th5 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.514 | |
| 4nyi | GNP | GTPase HRas | / | 0.513 | |
| 3a6p | GTP | GTP-binding nuclear protein Ran | / | 0.512 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.512 | |
| 4xoi | GTP | Transforming protein RhoA | / | 0.512 | |
| 1zc4 | GNP | Ras-related protein Ral-A | / | 0.509 | |
| 2cls | GTP | Rho-related GTP-binding protein Rho6 | / | 0.508 | |
| 3ddc | GNP | GTPase HRas | / | 0.508 | |
| 1gwn | GTP | Rho-related GTP-binding protein RhoE | / | 0.506 | |
| 2rgb | GNP | GTPase HRas | / | 0.505 | |
| 2c5l | GTP | GTPase HRas | / | 0.504 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.504 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.504 | |
| 3w3z | GTP | GTP-binding nuclear protein Ran | / | 0.504 | |
| 1g17 | GNP | Ras-related protein SEC4 | / | 0.503 | |
| 2bku | GTP | GTP-binding nuclear protein Ran | / | 0.503 | |
| 2rgc | GNP | GTPase HRas | / | 0.502 | |
| 3oiv | GNP | GTPase HRas | / | 0.502 | |
| 4nyj | GNP | GTPase HRas | / | 0.502 | |
| 4hdq | GNP | Ras-related protein Rap-1b | / | 0.497 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.495 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.494 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.494 | |
| 3lbn | GNP | GTPase HRas | / | 0.493 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.489 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.488 | |
| 2zet | GTP | Ras-related protein Rab-27B | / | 0.488 | |
| 4dlt | GNP | GTPase HRas | / | 0.488 | |
| 3kuc | GDP | Ras-related protein Rap-1A | / | 0.486 | |
| 4dsn | GCP | GTPase KRas | / | 0.486 | |
| 4o25 | GTP | GTP-binding protein Rheb | / | 0.486 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.485 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.485 | |
| 3tgp | GNP | GTPase HRas | / | 0.485 | |
| 1lfd | GNP | GTPase HRas | / | 0.484 | |
| 3oiu | GNP | GTPase HRas | / | 0.483 | |
| 4hdo | GNP | Ras-related protein Rap-1b | / | 0.483 | |
| 4xvr | GNP | GTPase HRas | / | 0.482 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.480 | |
| 3rab | GNP | Ras-related protein Rab-3A | / | 0.479 | |
| 4gzm | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.476 | |
| 3v4f | GNP | GTPase HRas | / | 0.473 | |
| 1z2c | GNP | Rho-related GTP-binding protein RhoC | / | 0.469 | |
| 4kvg | GTP | Ras-related protein Rap-1A | / | 0.466 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.465 | |
| 3oiw | GNP | GTPase HRas | / | 0.464 | |
| 1ibr | GNP | GTP-binding nuclear protein Ran | / | 0.463 | |
| 2ic5 | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.463 | |
| 4rkf | GNP | Ras-related protein Rab-3 | / | 0.463 | |
| 4dvg | GSP | Rho family GTPase | / | 0.461 | |
| 3sbe | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.460 | |
| 4gzl | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.460 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.459 | |
| 4g0n | GNP | GTPase HRas | / | 0.459 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.458 | |
| 5jlj | GNP | GTP-binding nuclear protein Ran | / | 0.458 | |
| 3lbh | GNP | GTPase HRas | / | 0.457 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.456 | |
| 3rs7 | GNP | GTPase HRas | / | 0.456 | |
| 4dlz | GNP | GTPase HRas | / | 0.456 | |
| 3l8y | GNP | GTPase HRas | / | 0.454 | |
| 2msd | GNP | MHC class I alpha chain | / | 0.453 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.452 | |
| 3ea5 | GDP | GTP-binding nuclear protein Ran | / | 0.452 | |
| 4dlw | GNP | GTPase HRas | / | 0.452 | |
| 3i3s | GNP | GTPase HRas | / | 0.450 | |
| 3tkl | GTP | Ras-related protein Rab-1A | / | 0.450 | |
| 3k8y | GNP | GTPase HRas | / | 0.448 | |
| 4xvq | GNP | GTPase HRas | / | 0.448 | |
| 5b2z | GNP | GTPase HRas | / | 0.448 | |
| 3lbi | GNP | GTPase HRas | / | 0.445 | |
| 2rgg | GNP | GTPase HRas | / | 0.444 | |
| 3rs5 | GNP | GTPase HRas | / | 0.444 | |
| 3x1z | GNP | Ras-related protein Rap-1b | / | 0.441 | |
| 2cl6 | CAG | GTPase HRas | / | 0.440 |