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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
6gsvGPSGlutathione S-transferase Mu 12.5.1.18

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
6gsvGPSGlutathione S-transferase Mu 12.5.1.181.000
3gstGPRGlutathione S-transferase Mu 12.5.1.180.592
1mtcGPRGlutathione S-transferase Mu 12.5.1.180.576
6gsuGPSGlutathione S-transferase Mu 12.5.1.180.573
6gswGPSGlutathione S-transferase Mu 12.5.1.180.548
2gstGPSGlutathione S-transferase Mu 12.5.1.180.538
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.502
4a802ANMajor pollen allergen Bet v 1-A/0.500
3gurBYGGlutathione S-transferase Mu 22.5.1.180.496
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.494
4bfzZVZPantothenate kinase2.7.1.330.492
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.489
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.487
2g247IGRenin3.4.23.150.484
4a862ANMajor pollen allergen Bet v 1-A/0.484
6gsxGPSGlutathione S-transferase Mu 12.5.1.180.484
2gv8NDPThiol-specific monooxygenase1.14.130.482
4a83DXCMajor pollen allergen Bet v 1-A/0.482
1b4pGPSGlutathione S-transferase Mu 2/0.481
2g1o2IGRenin3.4.23.150.481
4m83ERYOleandomycin glycosyltransferase2.4.10.481
1s63778Protein farnesyltransferase subunit beta2.5.1.580.480
2g1r3IGRenin3.4.23.150.480
1psa0ZLPepsin A3.4.23.10.479
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.479
3h3qH13Collagen type IV alpha-3-binding protein/0.478
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.477
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.477
3h3t16HCollagen type IV alpha-3-binding protein/0.475
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.475
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.474
2npfMOUElongation factor 2/0.474
1jedADPSulfate adenylyltransferase/0.473
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.473
1xddAAYIntegrin alpha-L/0.470
3t82SG4Carbonic anhydrase 24.2.1.10.470
1gtrATPGlutamine--tRNA ligase6.1.1.180.469
2g1s4IGRenin3.4.23.150.469
3iocA5DPantothenate synthetase6.3.2.10.469
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.468
1xe65FPPlasmepsin-23.4.23.390.468
2ikuLIYRenin3.4.23.150.468
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
4dptAGSMevalonate diphosphate decarboxylase/0.468
4jiq1L5GTN Reductase/0.468
1c7oPPGHemolysin/0.467
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.467
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.467
1tl7FOKAdenylate cyclase type 2/0.467
1tl7FOKAdenylate cyclase type 5/0.467
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.466
1xe55FEPlasmepsin-23.4.23.390.466
2iko7IGRenin3.4.23.150.466
2rqfJH3Hemolymph juvenile hormone binding protein/0.466
2x06NADL-sulfolactate dehydrogenase/0.466
4bfxZVXPantothenate kinase2.7.1.330.466
4i1iNADMalate dehydrogenase/0.466
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.466
1fm4DXCMajor pollen allergen Bet v 1-L/0.465
1vbiNADMalate/L-lactate dehydrogenase family protein/0.465
2i7nACOPantothenate kinase 12.7.1.330.465
2rlcCHDCholoylglycine hydrolase3.5.1.240.465
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3gwfNAPCyclohexanone monooxygenase/0.465
4dbc3QPAspartate aminotransferase2.6.1.10.465
2qw034Z4-chlorobenzoyl CoA ligase/0.464
2rhrEMOPutative ketoacyl reductase1.3.10.464
3h3sH15Collagen type IV alpha-3-binding protein/0.464
3qt62P0Mevalonate diphosphate decarboxylase/0.464
4a81DXCMajor pollen allergen Bet v 1-A/0.464
1culFOKAdenylate cyclase type 2/0.463
1culFOKAdenylate cyclase type 5/0.463
1h65GDPTranslocase of chloroplast 343.6.50.463
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.463
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.462
2i7pACOPantothenate kinase 32.7.1.330.462
3b2sB2STrichothecene 3-O-acetyltransferase/0.462
3hkuTORCarbonic anhydrase 24.2.1.10.462
1jd0AZMCarbonic anhydrase 124.2.1.10.461
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.461
3tjzGNPADP-ribosylation factor 1/0.461
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.461
2ea2F77Methionine aminopeptidase 2/0.460
2g1y5IGRenin3.4.23.150.460
2g226IGRenin3.4.23.150.460
2ok7FADFerredoxin--NADP reductase, apicoplast/0.460
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.460
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.459
2g1n1IGRenin3.4.23.150.459
3bl7DD1m7GpppX diphosphatase3.6.1.590.459
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.459
3eblGA4Gibberellin receptor GID1/0.459
3vt9YI4Vitamin D3 receptor/0.459
4psbGA3Cytokinin-specific binding protein/0.459
7stdCRPScytalone dehydratase4.2.1.940.459
1qr6NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.458
2oa7GTXGlutathione S-transferase P 12.5.1.180.458
3br3ETHTH-type transcriptional regulator QacR/0.458
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.458
3oqfS51Renin3.4.23.150.458
1w6hTITPlasmepsin-23.4.23.390.457
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.457
3fr5I4AFatty acid-binding protein, adipocyte/0.457
3o76GTBGlutathione S-transferase P 12.5.1.180.457
5irnADPNucleotide binding oligomerization domain containing 2/0.457
1a5bIGPTryptophan synthase alpha chain/0.456
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.456
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.456
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3fw3ETSCarbonic anhydrase 44.2.1.10.456
5ftcADPTPR domain protein/0.456
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.455
1bil0IURenin3.4.23.150.455
2ea4F79Methionine aminopeptidase 2/0.455
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.455
2pgtGPRGlutathione S-transferase P2.5.1.180.455
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.455
3fhxPLPPyridoxal kinase2.7.1.350.455
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.455
4cukNAID-lactate dehydrogenase/0.455
2zi53L1Deoxycytidine kinase2.7.1.740.454
3mauPLRPutative sphingosine-1-phosphate lyase/0.454
3q9bB3NAcetylpolyamine amidohydrolase/0.454
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.454
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
4uz6SCRPalmitoleoyl-protein carboxylesterase NOTUM/0.454
1hnaGDNGlutathione S-transferase Mu 22.5.1.180.453
1obbNADAlpha-glucosidase3.2.1.200.453
1ppjANYCytochrome b/0.453
1r58AO5Methionine aminopeptidase 2/0.453
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.453
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.453
3lqfNADGalactitol dehydrogenase/0.453
4bftZVTPantothenate kinase2.7.1.330.453
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.453
4jlm1NNDeoxycytidine kinase2.7.1.740.453
4pzrCOAHistone acetyltransferase p300/0.453
4q0kGA3Phytohormone-binding protein/0.453
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.452
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.452
2gjnFMNNitronate monooxygenase1.13.12.160.452
2il2LIXRenin3.4.23.150.452
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.452
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.452
1m13HYFNuclear receptor subfamily 1 group I member 2/0.451
2dvlFADAcyl-CoA dehydrogenase/0.451
2yd0BESEndoplasmic reticulum aminopeptidase 13.4.110.451
3c1y2BADNA integrity scanning protein DisA/0.451
3h2sNDPPutative NADH-flavin reductase/0.451
3h3r14HCollagen type IV alpha-3-binding protein/0.451
4a87NARMajor pollen allergen Bet v 1-A/0.451
4cdmFO1Deoxyribodipyrimidine photolyase/0.451
4n6hEJ4Delta-type opioid receptor/0.451
4yerADPAntibiotic ABC transporter, ATP-binding protein, putative/0.451
1fmlRTLRetinol dehydratase/0.450
1obnASVIsopenicillin N synthase1.21.3.10.450
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.450
1tehNADAlcohol dehydrogenase class-31.1.1.10.450
1toiHCIAspartate aminotransferase2.6.1.10.450
2d29FADAcyl-CoA dehydrogenase/0.450
3b4fTUOCarbonic anhydrase 24.2.1.10.450
3e8xNAPBH1520 protein/0.450
3phjDHKShikimate dehydrogenase (NADP(+))/0.450
4b4vL34Bifunctional protein FolD/0.450
4jxxATPGlutamine--tRNA ligase6.1.1.180.450
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.449
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.449
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.449
2a94AP0L-lactate dehydrogenase1.1.1.270.449
2g21L1BRenin3.4.23.150.449
2i4qUA4Renin3.4.23.150.449
2onmADPAldehyde dehydrogenase, mitochondrial1.2.1.30.449
2zshGA3Gibberellin receptor GID1A30.449
3bk2U5PRibonuclease J/0.449
3wagTYDGlycosyltransferase/0.449
4bfvZVVPantothenate kinase2.7.1.330.449
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.449
5cc9DDFDihydrofolate reductase1.5.1.30.449
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.448
1ra8FOLDihydrofolate reductase1.5.1.30.448
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.448
2dv3SAHDiphthine synthase/0.448
2ejzSAHDiphthine synthase/0.448
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.448
2xy3DUPSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.448
3igpDT7Carbonic anhydrase 24.2.1.10.448
3mjrAC2Deoxycytidine kinase2.7.1.740.448
3td7FADProbable FAD-linked sulfhydryl oxidase R5961.8.3.20.448
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.448
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.448
1t2cNAIL-lactate dehydrogenase1.1.1.270.447
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.447
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.447
3gncQQQGlutaryl-CoA dehydrogenase/0.447
4b4w9L9Bifunctional protein FolD/0.447
4jldADPAdenylate kinase/0.447
6stdMS2Scytalone dehydratase4.2.1.940.447
1a8rGTPGTP cyclohydrolase 13.5.4.160.446
1aqv0HGGlutathione S-transferase P2.5.1.180.446
2abaSTRPentaerythritol tetranitrate reductase/0.446
2qimZEAClass 10 plant pathogenesis-related protein/0.446
3ed1GA3Gibberellin receptor GID1/0.446
3mauEXTPutative sphingosine-1-phosphate lyase/0.446
3pfdFDAAcyl-CoA dehydrogenase FadE25/0.446
3rsv3RSBeta-secretase 13.4.23.460.446
4a84DXCMajor pollen allergen Bet v 1-A/0.446
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.446
4zj8SUVOrexin receptor type 1/0.446
1a9cGTPGTP cyclohydrolase 13.5.4.160.445
1h62ANBPentaerythritol tetranitrate reductase/0.445
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.445
1qrtATPGlutamine--tRNA ligase6.1.1.180.445
1xq04TRCarbonic anhydrase 24.2.1.10.445
2e15SAHDiphthine synthase/0.445
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.445
3apwDP0Alpha-1-acid glycoprotein 2/0.445
3hl0NADMaleylacetate reductase/0.445
3lzwNAPFerredoxin--NADP reductase 21.18.1.20.445
3p5pA3CTaxadiene synthase4.2.3.170.445
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.445
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.445
4drm0MCPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.445
4g7gVFVLanosterol 14-alpha-demethylase/0.445
4hmsFMNPhenazine biosynthesis protein PhzG1.40.445
1tkaN3TTransketolase 12.2.1.10.444
2c4jGSOGlutathione S-transferase Mu 22.5.1.180.444
2ibzUQ6Cytochrome b/0.444
3imgBZ3Pantothenate synthetase6.3.2.10.444
3qe2FMNNADPH--cytochrome P450 reductase/0.444
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.444
3vvpBNUUncharacterized protein/0.444
4bfuZVUPantothenate kinase2.7.1.330.444
4xq6FMNDihydroorotate dehydrogenase (quinone)/0.444
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.443
1h61PDNPentaerythritol tetranitrate reductase/0.443
1ikgREXD-alanyl-D-alanine carboxypeptidase3.4.16.40.443
1lbcCYZGlutamate receptor 2/0.443
1qtqQSIGlutamine--tRNA ligase6.1.1.180.443
1tu8GTXGlutathione S-transferase 22.5.1.180.443
2bi4NADLactaldehyde reductase1.1.1.770.443
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.443
2xfsJ01Uncharacterized protein/0.443
3fr28CAFatty acid-binding protein, adipocyte/0.443
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.443
3sxjSAMPutative methyltransferase/0.443
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.443
4ef4C2EStimulator of interferon genes protein/0.443
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.443
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1h73ANPHomoserine kinase2.7.1.390.442
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.442
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.442
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.442
2bjfDXCCholoylglycine hydrolase3.5.1.240.442
2gvdFKPAdenylate cyclase type 2/0.442
2gvdFKPAdenylate cyclase type 5/0.442
2uxoTACHTH-type transcriptional regulator TtgR/0.442
3hl4CDCCholine-phosphate cytidylyltransferase A/0.442
3kb1ADPIron-sulfur cluster carrier protein/0.442
3mj4URMUDP-galactopyranose mutase/0.442
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.442
4iae1DXAlr2278 protein/0.442
4lcjNADC-terminal-binding protein 2/0.442
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.442
1dr4HBIDihydrofolate reductase1.5.1.30.441
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.441
1uxjNADMalate dehydrogenase/0.441
2c20NADUDP-glucose 4-epimerase/0.441
2p6lSAHDiphthine synthase/0.441
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.441
2v59LZKBiotin carboxylase6.3.4.140.441
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.441
3oqkS52Renin3.4.23.150.441
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.441
4djaFAD(6-4) photolyase/0.441
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.441
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.441
4m4922YL-lactate dehydrogenase A chain1.1.1.270.441
4x7vMIVMycinamicin III 3''-O-methyltransferase2.1.1.2370.441
1cjkFOKAdenylate cyclase type 2/0.440
1cjkFOKAdenylate cyclase type 5/0.440
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.440
1p5rCOAFormyl-CoA:oxalate CoA-transferase/0.440
2dxdANPNucleoside diphosphate kinase2.7.4.60.440
2el3SAHDiphthine synthase/0.440
2eu3FF3Carbonic anhydrase 24.2.1.10.440
2hk9NAPShikimate dehydrogenase (NADP(+))/0.440
2vatCOAAcetyl-CoA--deacetylcephalosporin C acetyltransferase2.3.1.1750.440
3af1GDPPantothenate kinase2.7.1.330.440
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3own3OXRenin3.4.23.150.440
3ske054Genome polyprotein2.7.7.480.440
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.440
4layI63Peptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.440
4lh71X8DNA ligase/0.440
4mlp2CXCryptochrome-2/0.440
5stdUNNScytalone dehydratase4.2.1.940.440
6ctsCICCitrate synthase, mitochondrial2.3.3.10.440