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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5kp2COA3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5kp2COA3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2/1.000
4bb3KKAIsopenicillin N synthase1.21.3.10.483
2iviACWIsopenicillin N synthase1.21.3.10.471
3lqfNADGalactitol dehydrogenase/0.470
4uymVOR14-alpha sterol demethylase Cyp51B/0.467
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.465
2xw7NDPDihydrofolate reductase/0.464
4dvi2IWTankyrase-12.4.2.300.464
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.462
4rvgTYDD-mycarose 3-C-methyltransferase/0.461
2bu9HFVIsopenicillin N synthase1.21.3.10.460
3zoiM2WIsopenicillin N synthase1.21.3.10.460
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.458
4at0FADPossible succinate dehydrogenase/0.458
1pq944BOxysterols receptor LXR-beta/0.456
1pqc444Oxysterols receptor LXR-beta/0.455
4q0kGA3Phytohormone-binding protein/0.455
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.454
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.454
1xddAAYIntegrin alpha-L/0.454
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.454
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.453
3d4bDZDNAD-dependent protein deacetylase/0.452
3up0D7SaceDAF-12/0.452
4jqh1MFAlr2278 protein/0.452
3u8hBHPPhospholipase A2, membrane associated/0.450
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.448
2gv8NDPThiol-specific monooxygenase1.14.130.448
2xlpFADPutative flavin-containing monooxygenase/0.448
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.448
1kl2FONSerine hydroxymethyltransferase/0.447
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.447
3lfeZ84Mitogen-activated protein kinase 14/0.447
1uzwCDHIsopenicillin N synthase1.21.3.10.446
1cf3FADGlucose oxidase1.1.3.40.445
1p8dCO1Oxysterols receptor LXR-beta/0.445
3atzFMNProstaglandin F2a synthase/0.445
4iae1DXAlr2278 protein/0.445
2rm2W43Genome polyprotein/0.444
4b4w9L9Bifunctional protein FolD/0.444
1knrFADL-aspartate oxidase1.4.3.160.443
3w5rLOAVitamin D3 receptor/0.443
4bquCLRJapanin/0.443
5k2cZMAAdenosine receptor A2a/0.443
2flhZEACytokinin-specific binding protein/0.442
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.442
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.442
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3vt7VDXVitamin D3 receptor/0.441
1cjtFOKAdenylate cyclase type 2/0.440
1cjtFOKAdenylate cyclase type 5/0.440
1cjuFOKAdenylate cyclase type 2/0.440
1cjuFOKAdenylate cyclase type 5/0.440
2xlrFADPutative flavin-containing monooxygenase/0.440