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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5jtbZMAAdenosine receptor A2a

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5jtbZMAAdenosine receptor A2a/1.000
5k2dZMAAdenosine receptor A2a/0.683
5k2bZMAAdenosine receptor A2a/0.677
5k2cZMAAdenosine receptor A2a/0.674
5uviZMAAdenosine receptor A2a/0.657
5k2aZMAAdenosine receptor A2a/0.654
4eiyZMAAdenosine receptor A2a/0.640
5iua6DXAdenosine receptor A2a/0.638
5iu86DZAdenosine receptor A2a/0.637
3emlZMAAdenosine receptor A2a/0.627
5iubCLRAdenosine receptor A2a/0.595
5iu4ZMAAdenosine receptor A2a/0.576
4ug2NGIAdenosine receptor A2a/0.530
4uhrNGIAdenosine receptor A2a/0.524
5g53NECAdenosine receptor A2a/0.518
3vg9ZMAAdenosine receptor A2a/0.494
4iaq2GM5-hydroxytryptamine receptor 1B/0.477
2hcdBIVVitamin D3 receptor A/0.470
3qm4PN0Cytochrome P450 2D6/0.467
3vt65YIVitamin D3 receptor/0.465
4r20AERCytochrome P450 family 17 polypeptide 2/0.463
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.462
2zb8IMNProstaglandin reductase 21.3.1.480.460
3qwbNDPProbable quinone oxidoreductase1.6.5.50.460
3pwhZMAAdenosine receptor A2a/0.460
2o4rVD5Vitamin D3 receptor/0.457
3vt5YI2Vitamin D3 receptor/0.457
4ia3BIVVitamin D3 receptor A/0.457
4g1d0VKVitamin D3 receptor A/0.456
2ydvNECAdenosine receptor A2a/0.455
2zl9VDAVitamin D3 receptor/0.454
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.453
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.453
2zlaVDBVitamin D3 receptor/0.452
3tdaPN0Cytochrome P450 2D6/0.452
3vtdTKDVitamin D3 receptor/0.451
1db1VDXVitamin D3 receptor/0.450
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.450
2e48FADD-amino-acid oxidase1.4.3.30.450
3vt45YIVitamin D3 receptor/0.450
4r21STRCytochrome P450 family 17 polypeptide 2/0.450
4ruoBIVVitamin D3 receptor A/0.450
3ctj320Hepatocyte growth factor receptor2.7.10.10.449
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.449
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4equG6ISerine/threonine-protein kinase 102.7.11.10.448
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
3abiNADUncharacterized protein/0.447
3is9AC7Gag-Pol polyprotein2.7.7.490.447
2dvlFADAcyl-CoA dehydrogenase/0.446
3dr1C5DVitamin D3 receptor A/0.445
3ds6A17Mitogen-activated protein kinase 14/0.445
1blzACVIsopenicillin N synthase1.21.3.10.444
1tw2ERTCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.444
3w0hW12Vitamin D3 receptor/0.444
5hs1VORLanosterol 14-alpha demethylase/0.444
3qakUKAAdenosine receptor A2a/0.444
1p8dCO1Oxysterols receptor LXR-beta/0.443
1txiTX5Vitamin D3 receptor/0.443
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.443
1iyzNDPProbable quinone oxidoreductase/0.442
3hazFADBifunctional protein PutA/0.442
3kpzZNEVitamin D3 receptor/0.442
3tubFPUTyrosine-protein kinase SYK2.7.10.20.442
1bk0ACVIsopenicillin N synthase1.21.3.10.441
4fhi0S4Vitamin D3 receptor A/0.441
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1rk3VDXVitamin D3 receptor/0.440
3vtbTKAVitamin D3 receptor/0.440
3w0yDS4Vitamin D3 receptor/0.440
5dp2NAPCurF/0.440