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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5jlaNADPutative short-chain dehydrogenase/reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5jlaNADPutative short-chain dehydrogenase/reductase/1.000
2wsbNADGalactitol dehydrogenase/0.572
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.551
3sjuNDPKeto reductase/0.550
3wdsNADNADH-dependent quinuclidinone reductase/0.544
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.543
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.539
2wdzNADGalactitol dehydrogenase/0.539
1iy8NADLevodione reductase/0.532
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.531
4gh5NADShort-chain dehydrogenase/reductase SDR/0.528
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.523
4j7xNAPSepiapterin reductase1.1.1.1530.522
3ak4NADNADH-dependent quinuclidinone reductase/0.521
1ae1NAPTropinone reductase 1/0.518
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.518
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.516
4fn4NADShort chain dehydrogenase/0.516
1x7hNDPPutative ketoacyl reductase1.3.10.515
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.515
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.514
1mg5NAIAlcohol dehydrogenase1.1.1.10.513
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.512
3lqfNADGalactitol dehydrogenase/0.512
1w4zNAPPutative ketoacyl reductase1.3.10.511
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.508
4dc1NDPPutative ketoacyl reductase1.3.10.507
3w8eNAD3-hydroxybutyrate dehydrogenase/0.506
3toxNAPPutative oxidoreductase/0.505
1ipeNDPTropinone reductase 21.1.1.2360.504
3rj9NADAlcohol dehydrogenase1.1.1.10.503
4hwkNAPSepiapterin reductase1.1.1.1530.503
1zemNADXylitol dehydrogenase/0.502
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.499
4yaiNAIC alpha-dehydrogenase/0.499
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.498
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.498
4j7uNAPSepiapterin reductase1.1.1.1530.498
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.497
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.497
4nbwNADShort-chain dehydrogenase/reductase SDR/0.497
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.496
1snyNAPLD36273p/0.496
5lc1NADL-threonine 3-dehydrogenase/0.496
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.495
1sbyNADAlcohol dehydrogenase1.1.1.10.494
3d3wNAPL-xylulose reductase1.1.1.100.494
1b15NAEAlcohol dehydrogenase1.1.1.10.493
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.493
1n5dNDPCarbonyl reductase [NADPH] 1/0.492
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.492
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.491
2dteNAIGlucose 1-dehydrogenase related protein/0.491
3vdqNAD3-hydroxybutyrate dehydrogenase/0.491
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.491
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.491
1b16NAQAlcohol dehydrogenase1.1.1.10.490
2yutNAPPutative short-chain oxidoreductase/0.490
3qrwNDPPutative ketoacyl reductase1.3.10.490
2bd0NAPSepiapterin reductase/0.489
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.489
4yagNAIC alpha-dehydrogenase/0.489
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.488
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.488
3a1nNADNDP-sugar epimerase/0.488
3uxyNADShort-chain dehydrogenase/reductase SDR/0.488
3w8fNAD3-hydroxybutyrate dehydrogenase/0.488
3p19NDPPutative blue fluorescent protein/0.487
1x7gNAPPutative ketoacyl reductase1.3.10.486
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.485
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.485
3rj5NADAlcohol dehydrogenase1.1.1.10.483
1g6kNADGlucose 1-dehydrogenase1.1.1.470.482
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.481
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.481
1gcoNADGlucose 1-dehydrogenase1.1.1.470.481
1pr9NAPL-xylulose reductase1.1.1.100.481
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.480
5idwNAPShort-chain dehydrogenase/reductase SDR/0.480
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.479
3w8dNAD3-hydroxybutyrate dehydrogenase/0.479
4qecNAPElxO/0.479
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.478
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.478
1wntNAPL-xylulose reductase1.1.1.100.477
3sx2NADUncharacterized protein/0.477
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.474
5ig2NADShort-chain dehydrogenase/reductase SDR/0.474
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.473
3s55NADPutative short-chain dehydrogenase/reductase/0.473
1geeNADGlucose 1-dehydrogenase1.1.1.470.472
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.471
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.471
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.471
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.470
1oaaNAPSepiapterin reductase1.1.1.1530.469
2yy7NADL-threonine dehydrogenase/0.469
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.469
3a4vNADNDP-sugar epimerase/0.467
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.467
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.467
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.467
3f1kNAPUncharacterized oxidoreductase YciK10.466
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.464
4esoNAPPutative oxidoreductase/0.464
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.462
3gy0NAPNAD(P)-dependent oxidoreductase/0.462
5jydNADShort chain dehydrogenase/0.461
1rwbNADGlucose 1-dehydrogenase1.1.1.470.460
1xg5NAPDehydrogenase/reductase SDR family member 11/0.460
1b14NADAlcohol dehydrogenase1.1.1.10.457
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.457
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.457
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.456
3l77NJPShort-chain alcohol dehydrogenase/0.454
1kvrNADUDP-glucose 4-epimerase5.1.3.20.453
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.453
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.452
4b79NADProbable short-chain dehydrogenase/0.452
2p5uNADUDP-glucose 4-epimerase/0.451
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.450
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.449
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3ai2NDPNADPH-sorbose reductase/0.449
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.449
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.448
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.448
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.447
4bmvNAPShort-chain dehydrogenase/0.446
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.446
3ggoNAIPrephenate dehydrogenase/0.445
4qedNAPElxO/0.445
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.444
1i3lNADUDP-glucose 4-epimerase/0.444
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.443
1nahNADUDP-glucose 4-epimerase5.1.3.20.442
3tscNADUncharacterized protein/0.442
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.441
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.441
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440