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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5jhnSAMHistone-lysine N-methyltransferase EHMT2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5jhnSAMHistone-lysine N-methyltransferase EHMT2/1.000
5jj0SAMHistone-lysine N-methyltransferase EHMT2/0.720
2o8jSAHHistone-lysine N-methyltransferase EHMT2/0.633
5jinSAMHistone-lysine N-methyltransferase EHMT2/0.568
3hnaSAHHistone-lysine N-methyltransferase EHMT1/0.555
3kmtSAHHistone H3K27 methylase/0.545
2rfiSAHHistone-lysine N-methyltransferase EHMT1/0.521
5czySAMEukaryotic huntingtin interacting protein B/0.515
3ooiSAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific2.1.1.430.495
2cekN8TAcetylcholinesterase3.1.1.70.485
3ru0SFGHistone-lysine N-methyltransferase SMYD32.1.1.430.484
4ypaSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.479
3cbpSFGHistone-lysine N-methyltransferase SETD72.1.1.430.477
3swcSAHHistone-lysine N-methyltransferase EHMT1/0.475
3pdnSFGHistone-lysine N-methyltransferase SMYD32.1.1.430.473
4ypeSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.468
2xvfFADPutative flavin-containing monooxygenase/0.463
4qenSAHHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH42.1.1.430.463
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.461
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.461
4ynmSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.461
2xukTZ5Acetylcholinesterase3.1.1.70.459
2xuiTZ5Acetylcholinesterase3.1.1.70.458
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.456
4j83SAMHistone-lysine N-methyltransferase SETD72.1.1.430.456
2h21SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.455
4ypuSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.453
3vqsJT1Genome polyprotein/0.452
1bil0IURenin3.4.23.150.451
3n71SFGHistone-lysine N-methyltransferase Smyd1/0.450
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.448
4nv10FXFormyl transferase/0.448
1pqc444Oxysterols receptor LXR-beta/0.446
1zzuDP1Nitric oxide synthase, brain1.14.13.390.446
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.446
4djw0KPBeta-secretase 13.4.23.460.445
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.444
2xuoTZ4Acetylcholinesterase3.1.1.70.444
2xufTZ4Acetylcholinesterase3.1.1.70.443
4o30SAHProbable Histone-lysine N-methyltransferase ATXR52.1.1.430.443
2fs4PZ1Renin3.4.23.150.441
4nv14TGFormyl transferase/0.441
3aho3A2Oligopeptidase/0.440
3fktSIIBeta-secretase 13.4.23.460.440
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.440
3pm1ETHTH-type transcriptional regulator QacR/0.440
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.440