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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5iqbGNPBifunctional AAC/APH2.3.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5iqbGNPBifunctional AAC/APH2.3.11.000
5iqdGNPBifunctional AAC/APH2.3.10.716
5iqaGNPBifunctional AAC/APH2.3.10.681
5bylGCPBifunctional AAC/APH2.3.10.670
5iqeGNPBifunctional AAC/APH2.3.10.636
5iqhGNPBifunctional AAC/APH2.3.10.620
5iqiGNPBifunctional AAC/APH2.3.10.618
5iqgGDPBifunctional AAC/APH2.3.10.610
5iqfGDPBifunctional AAC/APH2.3.10.591
4orkGDPBifunctional AAC/APH2.3.10.575
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.474
2hq9FADMll6688 protein/0.473
4dh3ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
4ix5ANPUncharacterized protein/0.469
5dp2NAPCurF/0.469
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
2puiADPMethylthioribose kinase2.7.1.1000.467
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
4xj3GTPCyclic GMP-AMP synthase/0.467
3kpfFADPolyamine oxidase1.5.3.140.466
3up0D7SaceDAF-12/0.466
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.465
2dw4FADLysine-specific histone demethylase 1A10.464
3arvSAUChitinase A/0.464
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.462
3qtsX46Cyclin-dependent kinase 22.7.11.220.462
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4uofDATNucleoside diphosphate kinase/0.462
5ce3ADPProtein kinase YopO/0.460
1pd9CO4Dihydrofolate reductase1.5.1.30.458
3tdwGDPGentamicin resistance protein/0.458
4iafADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
1jpaANPEphrin type-B receptor 22.7.10.10.457
3idbANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
1h83FADPolyamine oxidase1.5.3.140.456
3gc9B45Mitogen-activated protein kinase 112.7.11.240.456
3nga3NGCasein kinase II subunit alpha2.7.11.10.456
3tdvGDPGentamicin resistance protein/0.455
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.454
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.453
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.453
1psdNADD-3-phosphoglycerate dehydrogenase1.1.1.950.452
4ia1BIVVitamin D3 receptor A/0.451
1o6qR17Squalene--hopene cyclase4.2.1.1290.450
2g8yNADHydroxycarboxylate dehydrogenase B/0.450
4z34ON7Lysophosphatidic acid receptor 1/0.450
1cdkANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.449
2hm9TRRDihydrofolate reductase1.5.1.30.449
4dieC5PCytidylate kinase/0.449
4tvbNADHomospermidine synthase2.5.1.440.449
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1x8b824Wee1-like protein kinase2.7.10.20.448
3bgxTMPThymidylate synthase/0.448
3sf6FDAGlutaryl-CoA dehydrogenase/0.448
2bkkADPAminoglycoside 3'-phosphotransferase2.7.1.950.447
3itzP66Mitogen-activated protein kinase 14/0.447
4bfyZVYPantothenate kinase2.7.1.330.447
4f1yCNIGlutamate receptor 3/0.447
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.447
1xpqFADPolyamine oxidase FMS1/0.446
2dr3ADPUPF0273 protein PH0284/0.446
2vd5BI8Myotonin-protein kinase2.7.11.10.446
3bbfGDPNucleoside diphosphate kinase B2.7.4.60.446
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.446
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1bwlFMNNADPH dehydrogenase 11.6.99.10.445
1zzlTZYMitogen-activated protein kinase 14/0.445
3adaNADSubunit alpha of sarocosine oxidase/0.445
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.445
1mczRMNBenzoylformate decarboxylase4.1.1.70.444
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.444
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.444
2qocANPEphrin type-A receptor 32.7.10.10.444
4askK0ILysine-specific demethylase 6B1.14.110.444
4iadADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
4echFADPolyamine oxidase FMS1/0.443
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.443
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4ma628EAra h 8 allergen/0.443
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2qcsANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.442
4xj43ATCyclic GMP-AMP synthase/0.442
5dozNDPJamJ/0.442
1sq5ADPPantothenate kinase2.7.1.330.441
3rpr25ZCyclin-dependent kinase 22.7.11.220.441
3w8eNAD3-hydroxybutyrate dehydrogenase/0.441
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4pd6URINucleoside permease/0.441
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.440
2p2fCOAAcetyl-coenzyme A synthetase/0.440
2yac937Serine/threonine-protein kinase PLK12.7.11.210.440
3ddw055Glycogen phosphorylase, liver form2.4.1.10.440
3hu1AGSTransitional endoplasmic reticulum ATPase3.6.4.60.440
3hu3AGSTransitional endoplasmic reticulum ATPase3.6.4.60.440
3pqbVGPPutative oxidoreductase/0.440
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4dshFDAUncharacterized protein/0.440
4uugPXGBranched-chain amino acid aminotransferase, putative/0.440