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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5iotUMPFlavin-dependent thymidylate synthase2.1.1.148

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5iotUMPFlavin-dependent thymidylate synthase2.1.1.1481.000
3q43D66M1 family aminopeptidase3.4.110.461
5ig2NADShort-chain dehydrogenase/reductase SDR/0.460
2rc6NAPFerredoxin--NADP reductase/0.457
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.451
3q44D50M1 family aminopeptidase3.4.110.450
4oagADPMitochondrial dynamics protein MID51/0.450
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.448
1tllNAPNitric oxide synthase, brain1.14.13.390.446
4a5lNDPThioredoxin reductase/0.444
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3oeeANPATP synthase subunit alpha, mitochondrial/0.443
3oeeANPATP synthase subunit beta, mitochondrial3.6.3.140.443
2hldANPATP synthase subunit alpha, mitochondrial/0.441
2hldANPATP synthase subunit beta, mitochondrial3.6.3.140.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4dieC5PCytidylate kinase/0.441
2yutNAPPutative short-chain oxidoreductase/0.440
3cx4ADPGlycogen synthase2.4.1.210.440