Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
5hi2 | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
5hi2 | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 1.000 | |
4fc0 | 0T2 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.637 | |
4ksp | 1SU | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.581 | |
3hv5 | R24 | Mitogen-activated protein kinase 14 | / | 0.566 | |
4aa0 | AA0 | Mitogen-activated protein kinase 14 | / | 0.531 | |
4agw | NG7 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.528 | |
3efl | 706 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.524 | |
3dtw | A96 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.520 | |
3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.518 | |
3kq7 | KQ7 | Mitogen-activated protein kinase 14 | / | 0.517 | |
4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.516 | |
2oiq | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.512 | |
2hyy | STI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.506 | |
3hng | 8ST | Vascular endothelial growth factor receptor 1 | 2.7.10.1 | 0.505 | |
3vnt | 0JA | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.505 | |
1iep | STI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.502 | |
3cp9 | C19 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.494 | |
3gcs | BAX | Mitogen-activated protein kinase 14 | / | 0.488 | |
4ase | AV9 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.488 | |
2qu6 | 857 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.481 | |
2xir | 00J | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.480 | |
2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.476 | |
4o2z | 046 | Mitogen-activated protein kinase | / | 0.476 | |
3eta | 351 | Insulin receptor | 2.7.10.1 | 0.471 | |
4eyj | N61 | Mitogen-activated protein kinase 13 | 2.7.11.24 | 0.467 | |
2p2i | 608 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.458 | |
4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.453 | |
3vhk | BPK | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.450 |