Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
5gcn | COA | HAT A1 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
5gcn | COA | HAT A1 | / | 1.000 | |
5iub | CLR | Adenosine receptor A2a | / | 0.519 | |
1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.517 | |
5iu4 | ZMA | Adenosine receptor A2a | / | 0.517 | |
1xdd | AAY | Integrin alpha-L | / | 0.515 | |
5jtb | ZMA | Adenosine receptor A2a | / | 0.512 | |
2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.508 | |
5g53 | NEC | Adenosine receptor A2a | / | 0.507 | |
4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.506 | |
5hbs | RTL | Retinol-binding protein 1 | / | 0.506 | |
3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.505 | |
5iua | 6DX | Adenosine receptor A2a | / | 0.505 | |
1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.502 | |
5uvi | ZMA | Adenosine receptor A2a | / | 0.502 | |
1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.500 | |
2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.500 | |
4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.499 | |
2ydo | ADN | Adenosine receptor A2a | / | 0.499 | |
3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.498 | |
4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.497 | |
1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.496 | |
1fmj | RTL | Retinol dehydratase | / | 0.496 | |
3bgx | MEF | Thymidylate synthase | / | 0.496 | |
3eml | ZMA | Adenosine receptor A2a | / | 0.496 | |
2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.495 | |
3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.495 | |
4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.493 | |
1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
4j26 | EST | Estrogen receptor beta | / | 0.492 | |
5fsx | ADP | Uncharacterized protein | / | 0.492 | |
3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.491 | |
3qly | 55V | Uncharacterized protein | / | 0.490 | |
4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.490 | |
3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.489 | |
1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.487 | |
2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.487 | |
4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.486 | |
4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
2b1z | 17M | Estrogen receptor | / | 0.485 | |
2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
3up3 | XCA | aceDAF-12 | / | 0.485 | |
5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.485 | |
1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.484 | |
4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.484 | |
3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.483 | |
3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.483 | |
1ppj | ANY | Cytochrome b | / | 0.482 | |
2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.482 | |
3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.482 | |
1qsn | COA | HAT A1 | / | 0.481 | |
2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.481 | |
3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.481 | |
4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.481 | |
1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.480 | |
1zky | 689 | Estrogen receptor | / | 0.480 | |
3gb4 | D3M | DdmC | / | 0.480 | |
3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.480 | |
4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.480 | |
4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.480 | |
5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
1s64 | 778 | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.479 | |
1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.479 | |
4eiy | ZMA | Adenosine receptor A2a | / | 0.479 | |
1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
5k2c | ZMA | Adenosine receptor A2a | / | 0.478 | |
5k2a | ZMA | Adenosine receptor A2a | / | 0.478 | |
1f5f | DHT | Sex hormone-binding globulin | / | 0.477 | |
1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.477 | |
2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.477 | |
3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.477 | |
3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.477 | |
3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.477 | |
3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.477 | |
3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.477 | |
1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.476 | |
3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.476 | |
3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.476 | |
4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.476 | |
4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.476 | |
1crb | RTL | Retinol-binding protein 1 | / | 0.475 | |
2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.475 | |
3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.475 | |
1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.474 | |
3aba | FLI | Cytochrome P450 | / | 0.474 | |
3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.474 | |
3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.474 | |
3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.474 | |
4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.474 | |
4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.474 | |
1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.473 | |
1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.473 | |
2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.473 | |
3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.473 | |
3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.473 | |
4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.473 | |
4pxm | EST | Estrogen receptor | / | 0.473 | |
5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.473 | |
5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.473 | |
1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.472 | |
4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.472 | |
4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.472 | |
1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.471 | |
1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.471 | |
3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.471 | |
3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.470 | |
4fr1 | 0V2 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.470 | |
4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.470 | |
5k2b | ZMA | Adenosine receptor A2a | / | 0.470 | |
1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.469 | |
1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.469 | |
1rgs | CMP | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.469 | |
1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.469 | |
2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.469 | |
2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.469 | |
3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.469 | |
1r8q | AFB | Cytohesin-2 | / | 0.468 | |
1r8q | AFB | ADP-ribosylation factor 1 | / | 0.468 | |
1upw | 444 | Oxysterols receptor LXR-beta | / | 0.468 | |
2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.468 | |
3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
3oll | EST | Estrogen receptor beta | / | 0.468 | |
4qzu | RTL | Retinol-binding protein 2 | / | 0.468 | |
5dp2 | NAP | CurF | / | 0.468 | |
1r2j | FAD | FkbI | / | 0.467 | |
2dvo | ITT | dITP/XTP pyrophosphatase | 3.6.1.19 | 0.467 | |
2fto | CB3 | Thymidylate synthase | / | 0.467 | |
2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.467 | |
3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.467 | |
3p2o | NAD | Bifunctional protein FolD | / | 0.467 | |
4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
4b4w | 9L9 | Bifunctional protein FolD | / | 0.467 | |
4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.467 | |
4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.467 | |
4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.467 | |
4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.467 | |
4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.467 | |
1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.466 | |
1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.466 | |
2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.466 | |
3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.466 | |
3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.466 | |
3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.466 | |
3v2u | ATP | Protein GAL3 | / | 0.466 | |
4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.466 | |
4giy | 0WY | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.466 | |
1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.465 | |
2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.465 | |
2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.465 | |
2rab | NAD | Glutathione amide reductase | / | 0.465 | |
2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.465 | |
3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.465 | |
4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
4uoh | ADP | Nucleoside diphosphate kinase | / | 0.465 | |
5k2d | ZMA | Adenosine receptor A2a | / | 0.465 | |
1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
1l0o | ADP | Anti-sigma F factor | / | 0.464 | |
2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.464 | |
4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
4j6d | TES | Cytochrome P450 monooxygenase | / | 0.464 | |
4nie | NBH | Nuclear receptor ROR-gamma | / | 0.464 | |
4tqq | UQ1 | Reaction center protein L chain | / | 0.464 | |
1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.463 | |
1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.463 | |
1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.463 | |
1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.463 | |
2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.463 | |
3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.463 | |
3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.463 | |
4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.463 | |
4ktl | 1CQ | Cytochrome P450 | / | 0.463 | |
1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.462 | |
2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.462 | |
3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.462 | |
3med | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.462 | |
3q95 | ESL | Estrogen receptor | / | 0.462 | |
3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.461 | |
1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
1l2i | ETC | Estrogen receptor | / | 0.461 | |
2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.461 | |
2xve | FAD | Putative flavin-containing monooxygenase | / | 0.461 | |
3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.461 | |
3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.461 | |
3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
4b4v | L34 | Bifunctional protein FolD | / | 0.461 | |
4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
3arv | SAU | Chitinase A | / | 0.460 | |
4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
4iae | 1DX | Alr2278 protein | / | 0.460 | |
4jqh | 1MF | Alr2278 protein | / | 0.460 | |
1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.459 | |
1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.459 | |
1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
1tdu | CB3 | Thymidylate synthase | / | 0.459 | |
1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.459 | |
2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.459 | |
2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.459 | |
3eku | CY9 | Actin-5C | / | 0.459 | |
3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
3gkj | HC3 | Niemann-Pick C1 protein | / | 0.459 | |
3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.459 | |
3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.459 | |
4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.459 | |
5cb5 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.459 | |
5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.459 | |
2bif | ANP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.458 | |
2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.458 | |
2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.458 | |
2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.458 | |
2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.458 | |
3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.458 | |
3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
3q2m | CKI | Spectinomycin phosphotransferase | / | 0.458 | |
3tda | PN0 | Cytochrome P450 2D6 | / | 0.458 | |
3vtc | TK3 | Vitamin D3 receptor | / | 0.458 | |
4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.458 | |
4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.458 | |
4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.458 | |
4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
1cqp | 803 | Integrin alpha-L | / | 0.457 | |
1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.457 | |
1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
1qm5 | PLP | Maltodextrin phosphorylase | 2.4.1.1 | 0.457 | |
1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.457 | |
2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.457 | |
2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.457 | |
2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.457 | |
2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.457 | |
2vcw | ZZA | Hematopoietic prostaglandin D synthase | / | 0.457 | |
2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.457 | |
2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
2yat | EEU | Estrogen receptor | / | 0.457 | |
3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
3h18 | PMS | Esterase/lipase | / | 0.457 | |
3njo | PYV | Abscisic acid receptor PYR1 | / | 0.457 | |
3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
3uud | EST | Estrogen receptor | / | 0.457 | |
3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.457 | |
4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.457 | |
4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.457 | |
4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.457 | |
4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.457 | |
4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.457 | |
1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
1x8l | OXR | Retinol dehydratase | / | 0.456 | |
2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.456 | |
2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.456 | |
2ocf | EST | Estrogen receptor | / | 0.456 | |
3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
3up0 | D7S | aceDAF-12 | / | 0.456 | |
4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.456 | |
4j6c | STR | Cytochrome P450 monooxygenase | / | 0.456 | |
4k37 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.456 | |
1a4z | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.455 | |
1b4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.455 | |
1re0 | AFB | ADP-ribosylation factor 1 | / | 0.455 | |
1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.455 | |
2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.455 | |
2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.455 | |
2xtb | KRM | Adenosine kinase, putative | / | 0.455 | |
2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.455 | |
3cop | ADP | Glycogen synthase | 2.4.1.21 | 0.455 | |
3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.455 | |
3tm5 | SFG | Uncharacterized protein | / | 0.455 | |
3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
4at0 | FAD | Possible succinate dehydrogenase | / | 0.455 | |
4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.455 | |
4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
3qak | UKA | Adenosine receptor A2a | / | 0.455 | |
1ddu | CB3 | Thymidylate synthase | / | 0.454 | |
1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
1svl | ADP | Large T antigen | 3.6.4 | 0.454 | |
1x7r | GEN | Estrogen receptor | / | 0.454 | |
2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.454 | |
2fhn | BNI | Avidin-related protein 4/5 | / | 0.454 | |
2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.454 | |
2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
2x9v | TMQ | Pteridine reductase | / | 0.454 | |
2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.454 | |
3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.454 | |
3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.454 | |
3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.454 | |
3gl2 | D3M | DdmC | / | 0.454 | |
3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.454 | |
3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.454 | |
3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.454 | |
4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.454 | |
4b2g | V1N | Uncharacterized protein | / | 0.454 | |
4fhd | 0TT | Spore photoproduct lyase | / | 0.454 | |
4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.454 | |
1fml | RTL | Retinol dehydratase | / | 0.453 | |
1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.453 | |
3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.453 | |
3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.453 | |
5ckw | ANP | Uncharacterized protein | / | 0.453 | |
5h8t | RTL | Retinol-binding protein 1 | / | 0.453 | |
3rfm | CFF | Adenosine receptor A2a | / | 0.453 | |
1c7o | PPG | Hemolysin | / | 0.452 | |
1d2s | DHT | Sex hormone-binding globulin | / | 0.452 | |
1gnw | GTX | Glutathione S-transferase F2 | 2.5.1.18 | 0.452 | |
1gwr | EST | Estrogen receptor | / | 0.452 | |
1lri | CLR | Beta-elicitin cryptogein | / | 0.452 | |
1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.452 | |
1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.452 | |
1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
2fai | 459 | Estrogen receptor | / | 0.452 | |
2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.452 | |
2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.452 | |
2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.452 | |
2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.452 | |
3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.452 | |
3kr6 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.452 | |
3oji | PYV | Abscisic acid receptor PYL3 | / | 0.452 | |
3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.452 | |
4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.452 | |
4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.452 | |
4f1o | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.452 | |
5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.452 | |
1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.451 | |
1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.451 | |
1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
1n4q | LYS_CYS_VAL_ILE_LEU | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.451 | |
1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.451 | |
2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.451 | |
2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
2vke | TAC | Tetracycline repressor protein class D | / | 0.451 | |
3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.451 | |
3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.451 | |
3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
3p3z | P3Z | Putative cytochrome P450 | / | 0.451 | |
3vrw | YS5 | Vitamin D3 receptor | / | 0.451 | |
4bmp | FMN | Protein NrdI | / | 0.451 | |
4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.451 | |
4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.451 | |
4ixd | 1HV | Integrin alpha-L | / | 0.451 | |
4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.451 | |
1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.450 | |
1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.450 | |
1s36 | CEI | Obelin | / | 0.450 | |
2g44 | T3O | Estrogen receptor | / | 0.450 | |
2p4i | MR9 | Angiopoietin-1 receptor | 2.7.10.1 | 0.450 | |
2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.450 | |
3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.450 | |
3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
3ry2 | BTN | Streptavidin | / | 0.450 | |
3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.450 | |
3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.450 | |
3zv5 | BPY | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.450 | |
4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.450 | |
4ehy | ADP | Tetraacyldisaccharide 4'-kinase | / | 0.450 | |
4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.450 | |
4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.450 | |
4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.450 | |
4lb2 | DM5 | Serum albumin | / | 0.450 | |
4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.450 | |
4p53 | NAI | 2-epi-5-epi-valiolone synthase | / | 0.450 | |
4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.450 | |
4xiv | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.450 | |
1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.449 | |
1iiu | RTL | Retinol-binding protein 4 | / | 0.449 | |
1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.449 | |
1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.449 | |
1yin | CM3 | Estrogen receptor | / | 0.449 | |
2fdy | D4G | Cytochrome P450 2A6 | 1.14.13 | 0.449 | |
2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.449 | |
2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.449 | |
2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
2ydv | NEC | Adenosine receptor A2a | / | 0.449 | |
2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.449 | |
3bhr | THG | Thymidylate synthase | / | 0.449 | |
3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
3nmv | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
3v94 | WYQ | Phosphodiesterase | / | 0.449 | |
4ea1 | 3RX | Dehydrosqualene synthase | / | 0.449 | |
4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.449 | |
4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.449 | |
4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.449 | |
1ne4 | RP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.448 | |
1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.448 | |
1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.448 | |
1x1c | SAH | C-20 methyltransferase | / | 0.448 | |
2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.448 | |
2e0i | FAD | DNA photolyase | / | 0.448 | |
2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.448 | |
2rjp | 886 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | 3.4.24.82 | 0.448 | |
2vqo | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.448 | |
3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.448 | |
3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.448 | |
3otq | MZL | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.448 | |
3p9t | TCL | Repressor | / | 0.448 | |
3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.448 | |
4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.448 | |
4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.448 | |
4c49 | HCY | Corticosteroid-binding globulin | / | 0.448 | |
4gev | CB3 | Thymidylate synthase | / | 0.448 | |
4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.448 | |
4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.448 | |
5fm7 | ADP | RuvB-like helicase | / | 0.448 | |
5iu8 | 6DZ | Adenosine receptor A2a | / | 0.448 | |
1cde | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.447 | |
1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.447 | |
1kt3 | RTL | Retinol-binding protein 4 | / | 0.447 | |
1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.447 | |
1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.447 | |
2p15 | EZT | Estrogen receptor | / | 0.447 | |
2qgt | EED | Estrogen receptor | / | 0.447 | |
2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.447 | |
2y88 | 2ER | Phosphoribosyl isomerase A | 5.3.1.16 | 0.447 | |
3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
3d4b | DZD | NAD-dependent protein deacetylase | / | 0.447 | |
3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
3g7f | UQ1 | Reaction center protein L chain | / | 0.447 | |
3huc | G97 | Mitogen-activated protein kinase 14 | / | 0.447 | |
3l6j | Z90 | Alr2278 protein | / | 0.447 | |
3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
3pqb | VGP | Putative oxidoreductase | / | 0.447 | |
4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.447 | |
4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.447 | |
4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
4ffr | ATP | Uncharacterized protein | / | 0.447 | |
4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.447 | |
1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
1jjt | BDS | Beta-lactamase | / | 0.446 | |
1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.446 | |
1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.446 | |
1opb | RET | Retinol-binding protein 2 | / | 0.446 | |
1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.446 | |
1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.446 | |
2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.446 | |
2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.446 | |
3cse | N22 | Uncharacterized protein | / | 0.446 | |
3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.446 | |
3jpu | TY4 | Transcriptional activator protein LasR | / | 0.446 | |
3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
3s79 | ASD | Aromatase | 1.14.14.14 | 0.446 | |
3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.446 | |
4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
4h6p | FMN | Chromate reductase | / | 0.446 | |
4ite | TEY | Vitamin D3 receptor | / | 0.446 | |
4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.446 | |
5l7d | CLR | Smoothened homolog | / | 0.446 | |
1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.445 | |
1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.445 | |
1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
1qkn | RAL | Estrogen receptor beta | / | 0.445 | |
1s19 | MC9 | Vitamin D3 receptor | / | 0.445 | |
1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.445 | |
2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.445 | |
2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.445 | |
2qa8 | GEN | Estrogen receptor | / | 0.445 | |
2rtm | IMI | Streptavidin | / | 0.445 | |
2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
3p5s | AVU | CD38 molecule | / | 0.445 | |
3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.445 | |
3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.445 | |
3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
4g21 | 0VP | Vitamin D3 receptor A | / | 0.445 | |
4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
4iah | 1DX | Alr2278 protein | / | 0.445 | |
4knz | CB3 | Thymidylate synthase | / | 0.445 | |
4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
4y9u | NAP | NADPH--cytochrome P450 reductase | / | 0.445 | |
1dfo | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.444 | |
1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.444 | |
1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.444 | |
1ie8 | KH1 | Vitamin D3 receptor | / | 0.444 | |
1l2j | ETC | Estrogen receptor beta | / | 0.444 | |
1n4s | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.444 | |
1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.444 | |
2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.444 | |
2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.444 | |
2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.444 | |
2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.444 | |
2wes | FAD | Tryptophan 5-halogenase | / | 0.444 | |
2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
3n5w | XFJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.444 | |
4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.444 | |
4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.444 | |
4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.444 | |
4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.444 | |
1hk4 | T44 | Serum albumin | / | 0.443 | |
1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
1rsg | FAD | Polyamine oxidase FMS1 | / | 0.443 | |
1x7j | GEN | Estrogen receptor beta | / | 0.443 | |
1y56 | FMN | Uncharacterized protein | / | 0.443 | |
1y56 | FMN | 382aa long hypothetical sarcosine oxidase | / | 0.443 | |
2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
2g5o | DRQ | Estrogen receptor | / | 0.443 | |
2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.443 | |
2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.443 | |
2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.443 | |
2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.443 | |
2yhu | WHF | Pteridine reductase | / | 0.443 | |
3bej | MUF | Bile acid receptor | / | 0.443 | |
3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.443 | |
3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
3neg | PYV | Abscisic acid receptor PYL1 | / | 0.443 | |
3q5p | TAC | Multidrug-efflux transporter 1 regulator | / | 0.443 | |
3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.443 | |
4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.443 | |
4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.443 | |
4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
4k36 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.443 | |
4ktf | 1TM | Cytochrome P450 | / | 0.443 | |
4nqg | CZH | Mitrocomin | / | 0.443 | |
4xiv | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.443 | |
5iw5 | NMN | NADH pyrophosphatase | / | 0.443 | |
1dtn | APG | Mandelate racemase | / | 0.442 | |
1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.442 | |
1kl2 | FON | Serine hydroxymethyltransferase | / | 0.442 | |
1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
1n3s | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.442 | |
1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.442 | |
1u0h | ONM | Adenylate cyclase type 2 | / | 0.442 | |
1u0h | ONM | Adenylate cyclase type 5 | / | 0.442 | |
1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
2oal | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.442 | |
2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
2p5u | NAD | UDP-glucose 4-epimerase | / | 0.442 | |
2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.442 | |
3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.442 | |
3hl0 | NAD | Maleylacetate reductase | / | 0.442 | |
3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.442 | |
4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
4l17 | DNQ | Glutamate receptor 2 | / | 0.442 | |
4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.442 | |
4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.442 | |
4y1b | NAP | AntE | / | 0.442 | |
5epe | SAH | Uncharacterized protein | / | 0.442 | |
4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.442 | |
1kqw | RTL | Cellular retinol-binding protein type II | / | 0.441 | |
1n71 | COA | Aac(6')-Ii protein | / | 0.441 | |
1tys | DHF | Thymidylate synthase | / | 0.441 | |
1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.441 | |
1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.441 | |
1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.441 | |
2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
2bkt | RPF | Renin | 3.4.23.15 | 0.441 | |
2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.441 | |
2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
2z4j | DHT | Androgen receptor | / | 0.441 | |
2zl9 | VDA | Vitamin D3 receptor | / | 0.441 | |
2zlc | VDX | Vitamin D3 receptor | / | 0.441 | |
3b05 | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
3c14 | FOK | Adenylate cyclase type 2 | / | 0.441 | |
3c14 | FOK | Adenylate cyclase type 5 | / | 0.441 | |
3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.441 | |
3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.441 | |
3ebf | 332 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.441 | |
3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
3kpz | ZNE | Vitamin D3 receptor | / | 0.441 | |
3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.441 | |
3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
3slk | NDP | Polyketide synthase extender module 2 | / | 0.441 | |
3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.441 | |
3uwl | FOZ | Thymidylate synthase | / | 0.441 | |
3w5p | 4OA | Vitamin D3 receptor | / | 0.441 | |
3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.441 | |
3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.441 | |
4fev | PP1 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
4gdp | FAD | Polyamine oxidase FMS1 | / | 0.441 | |
4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.441 | |
4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.441 | |
4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.441 | |
4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
1e3v | DXC | Steroid Delta-isomerase | 5.3.3.1 | 0.440 | |
1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.440 | |
1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.440 | |
1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.440 | |
1lhw | ESM | Sex hormone-binding globulin | / | 0.440 | |
1mra | APG | Mandelate racemase | / | 0.440 | |
1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.440 | |
1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.440 | |
1sui | FRE | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.440 | |
1thn | ADP | Anti-sigma F factor | / | 0.440 | |
1u3r | 338 | Estrogen receptor beta | / | 0.440 | |
1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.440 | |
2lfo | GCH | Fatty acid-binding protein, liver | / | 0.440 | |
2nom | DUT | Poly(A) polymerase, putative | / | 0.440 | |
2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.440 | |
3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.440 | |
3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
3jwc | EKB | Dihydrofolate reductase | / | 0.440 | |
3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
3py4 | TYL | Lactoperoxidase | 1.11.1.7 | 0.440 | |
3t2k | FAD | Sulfide-quinone reductase | / | 0.440 | |
3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.440 | |
3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
4ap1 | NAP | Steroid monooxygenase | / | 0.440 | |
4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.440 | |
4bew | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.440 | |
4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.440 | |
4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.440 | |
4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.440 | |
4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
4yek | THM | Thymidine phosphorylase | / | 0.440 | |
5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
5dxg | EST | Estrogen receptor | / | 0.440 | |
3uza | T4G | Adenosine receptor A2a | / | 0.440 |