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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5fs9FADApoptosis-inducing factor 1, mitochondrial1.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5fs9FADApoptosis-inducing factor 1, mitochondrial1.1.11.000
5fs6FADApoptosis-inducing factor 1, mitochondrial1.1.10.636
1m6iFADApoptosis-inducing factor 1, mitochondrial1.1.10.605
5fs8FADApoptosis-inducing factor 1, mitochondrial1.1.10.585
4bv6FADApoptosis-inducing factor 1, mitochondrial1.1.10.578
3gd3FADApoptosis-inducing factor 1, mitochondrial1.1.10.577
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.548
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.534
3lxdFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.530
1d7yFADFerredoxin reductase/0.529
4emjFADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.526
3ef6FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.524
3lb8FADPutidaredoxin reductase1.18.1.50.523
4h4sFADBiphenyl dioxygenase ferredoxin reductase subunit/0.521
2gr3FADFerredoxin reductase/0.515
4h50FADBiphenyl dioxygenase ferredoxin reductase subunit/0.513
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.511
4h4tFADBiphenyl dioxygenase ferredoxin reductase subunit/0.510
2gqwFADFerredoxin reductase/0.494
2gr0FADFerredoxin reductase/0.493
4h4rFADBiphenyl dioxygenase ferredoxin reductase subunit/0.493
4h4vFADBiphenyl dioxygenase ferredoxin reductase subunit/0.493
1nhsFADNADH peroxidase1.11.1.10.469
1nhpFADNADH peroxidase1.11.1.10.465
2gr1FADFerredoxin reductase/0.462
2r9zFADGlutathione amide reductase/0.460
3ictFADCoenzyme A disulfide reductase/0.457
1nhrFADNADH peroxidase1.11.1.10.451
3kljFADNADH-rubredoxin oxidoreductase1.18.1.10.449
3cgbFADCoenzyme A disulfide reductase/0.444
1zx9FADMercuric reductase1.16.1.10.441
3cgcFADCoenzyme A disulfide reductase/0.441