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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5fm6ADPRuvB-like helicase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5fm6ADPRuvB-like helicase/1.000
4ww4ADPRuvB-like helicase/0.619
3uk6ADPRuvB-like 23.6.4.120.503
1w5sADPORC1-type DNA replication protein 2/0.487
2z4sADPChromosomal replication initiator protein DnaA/0.471
5fm7ADPRuvB-like helicase/0.471
2xszATPRuvB-like 23.6.4.120.470
4ohwATPProtein clpf-1/0.468
1in5ADPHolliday junction ATP-dependent DNA helicase RuvB/0.461
2z6dFMNPhototropin-22.7.11.10.457
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.456
2pd7FADVivid PAS protein VVD/0.455
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.455
1a5uATPPyruvate kinase PKM2.7.1.400.454
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.452
1sxjAGSReplication factor C subunit 1/0.449
1njfADPDNA polymerase III subunit tau2.7.7.70.446
4c77N01Phenylacetone monooxygenase1.14.13.920.445
4zohFADPutative oxidoreductase FAD-binding subunit/0.445
4m4922YL-lactate dehydrogenase A chain1.1.1.270.444
2yltNAPPhenylacetone monooxygenase1.14.13.920.443
3fhxPLPPyridoxal kinase2.7.1.350.443
4dptAGSMevalonate diphosphate decarboxylase/0.443
4dpy2P0Mevalonate diphosphate decarboxylase/0.443
3bazNAPHydroxyphenylpyruvate reductase1.1.1.2370.441
1w49APCNTPase P4/0.440
3dvlATPCircadian clock protein kinase KaiC2.7.11.10.440