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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5fitAP2Bis(5'-adenosyl)-triphosphatase3.6.1.29

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5fitAP2Bis(5'-adenosyl)-triphosphatase3.6.1.291.000
1av5AP2Histidine triad nucleotide-binding protein 130.502
3eksCY9Actin-5C/0.495
3bhrTHGThymidylate synthase/0.494
3gkjHC3Niemann-Pick C1 protein/0.494
3q43D66M1 family aminopeptidase3.4.110.492
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.490
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.490
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.489
1pqc444Oxysterols receptor LXR-beta/0.486
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.485
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.484
2ydoADNAdenosine receptor A2a/0.483
3a1l2CCCytochrome P450/0.482
4jx1CAHCamphor 5-monooxygenase1.14.15.10.480
2aclL05Oxysterols receptor LXR-alpha/0.477
2xlpFADPutative flavin-containing monooxygenase/0.477
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.477
2vbpVB1Isopenicillin N synthase1.21.3.10.476
2z3uCRRCytochrome P450/0.476
4dvi2IWTankyrase-12.4.2.300.476
5i2fBS5Histidine triad nucleotide-binding protein 130.476
1pdhFASp-hydroxybenzoate hydroxylase/0.475
1txiTX5Vitamin D3 receptor/0.474
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.474
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.473
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.472
2am22LGUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.472
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.472
2ydd2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.472
2ydvNECAdenosine receptor A2a/0.472
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.472
3vt8YI3Vitamin D3 receptor/0.472
5g53NECAdenosine receptor A2a/0.472
1kqoDNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.471
1osvCHCBile acid receptor/0.471
1yqzCOACoenzyme A disulfide reductase/0.471
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.471
1oc1ASVIsopenicillin N synthase1.21.3.10.470
1rzy5ASHistidine triad nucleotide-binding protein 130.470
3fmz2T1Retinol-binding protein 4/0.470
3oxk5GPHistidine triad nucleotide-binding protein30.470
5cmx0G6Prothrombin3.4.21.50.470
5dbfNDPIridoid synthase1.3.1.990.470
1db1VDXVitamin D3 receptor/0.469
2uywBTNAvd protein/0.469
3ekuCY9Actin-5C/0.469
3fl4FL4Mitogen-activated protein kinase 14/0.469
4bb3KKAIsopenicillin N synthase1.21.3.10.469
4uhrNGIAdenosine receptor A2a/0.469
1bk0ACVIsopenicillin N synthase1.21.3.10.468
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.468
1nhkCMPNucleoside diphosphate kinase2.7.4.60.468
1zdwFLVPrenyltransferase/0.468
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
2gfsPQBMitogen-activated protein kinase 14/0.468
2po7CHDFerrochelatase, mitochondrial4.99.1.10.468
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.468
4jqh1MFAlr2278 protein/0.468
1iiuRTLRetinol-binding protein 4/0.467
1y52BTNAvidin-related protein 4/5/0.467
2dw4FADLysine-specific histone demethylase 1A10.467
2zb8IMNProstaglandin reductase 21.3.1.480.467
2vcmM11Isopenicillin N synthase1.21.3.10.466
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.466
4iah1DXAlr2278 protein/0.466
5dcyNAPIridoid synthase1.3.1.990.466
2ym2NAPPhenylacetone monooxygenase1.14.13.920.465
4eqrCOACoenzyme A disulfide reductase/0.465
5dozNDPJamJ/0.465
1h36R88Squalene--hopene cyclase4.2.1.1290.464
1obnASVIsopenicillin N synthase1.21.3.10.464
2hamC33Vitamin D3 receptor/0.464
2vmyFFOSerine hydroxymethyltransferase/0.464
2vqbFADPutative flavin-containing monooxygenase/0.464
2vqoTFGHistone deacetylase 43.5.1.980.464
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.464
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.464
1egdFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.463
1pq944BOxysterols receptor LXR-beta/0.463
1rkhVD2Vitamin D3 receptor/0.463
1s3uTQDDihydrofolate reductase1.5.1.30.463
2fiwACOGCN5-related N-acetyltransferase:Aminotransferase, class-II/0.463
2lfoGCHFatty acid-binding protein, liver/0.463
2y6fM9FIsopenicillin N synthase1.21.3.10.463
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.463
3kybFADUDP-galactopyranose mutase5.4.99.90.463
3kytHC2Nuclear receptor ROR-gamma/0.463
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
4kbyC2EStimulator of interferon genes protein/0.463
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.463
1blzACVIsopenicillin N synthase1.21.3.10.462
1d6w00RProthrombin3.4.21.50.462
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.462
1hvyD16Thymidylate synthase2.1.1.450.462
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.462
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.462
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.462
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.462
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.462
5bt42LOBromodomain-containing protein 4/0.462
1o6rR19Squalene--hopene cyclase4.2.1.1290.461
1q19SSCCarbapenam-3-carboxylate synthase6.3.3.60.461
1qjfACSIsopenicillin N synthase1.21.3.10.461
1uopGLY_PHE_GLU_PROProlyl endopeptidase3.4.21.260.461
2xvfFADPutative flavin-containing monooxygenase/0.461
2yphQQY2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.461
3bg7FADPyranose 2-oxidase/0.461
3q8uADPNucleoside diphosphate kinase/0.461
3uk6ADPRuvB-like 23.6.4.120.461
4o7uTHFThymidylate synthase/0.461
1cf3FADGlucose oxidase1.1.3.40.460
1hfqMOTDihydrofolate reductase1.5.1.30.460
1jnzFADAdenylylsulfate reductase, subunit A (AprA)/0.460
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.460
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.460
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.460
3k4nFADPyranose 2-oxidase/0.460
3pfdFDAAcyl-CoA dehydrogenase FadE25/0.460
4bftZVTPantothenate kinase2.7.1.330.460
4irnFADAnaB/0.460
1fxsNAPGDP-L-fucose synthase/0.459
1hb1OCVIsopenicillin N synthase1.21.3.10.459
2x7hPFNProstaglandin reductase 310.459
3atzFMNProstaglandin F2a synthase/0.459
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.459
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.459
5irnADPNucleotide binding oligomerization domain containing 2/0.459
1d3dBZTProthrombin3.4.21.50.458
1upw444Oxysterols receptor LXR-beta/0.458
2uuk897Prothrombin3.4.21.50.458
2zwaSAHtRNA wybutosine-synthesizing protein 42.1.1.2900.458
3itzP66Mitogen-activated protein kinase 14/0.458
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3zkyWT4Isopenicillin N synthase1.21.3.10.458
3zoiM2WIsopenicillin N synthase1.21.3.10.458
4bfxZVXPantothenate kinase2.7.1.330.458
4k88HFGBifunctional glutamate/proline--tRNA ligase6.1.1.150.458
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.458
1dgfNDPCatalase1.11.1.60.457
1kt6RTLRetinol-binding protein 4/0.457
1uyePU9Heat shock protein HSP 90-alpha/0.457
2p83MR0Beta-secretase 13.4.23.460.457
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.457
2xnvVU3Soluble acetylcholine receptor/0.457
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.457
3qgzADNHistidine triad nucleotide-binding protein 130.457
4a87NARMajor pollen allergen Bet v 1-A/0.457
4fam0SZAldo-keto reductase family 1 member C3/0.457
4uymVOR14-alpha sterol demethylase Cyp51B/0.457
5emhNAPIridoid synthase1.3.1.990.457
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.456
2fjaFADAdenylylsulfate reductase, subunit A (AprA)/0.456
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.456
2p4iMR9Angiopoietin-1 receptor2.7.10.10.456
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.456
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.456
3ogwIMNLactoperoxidase1.11.1.70.456
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.456
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.456
5dp2NAPCurF/0.456
1fwkADPHomoserine kinase2.7.1.390.455
1hb3SCVIsopenicillin N synthase1.21.3.10.455
1ot7IU5Bile acid receptor/0.455
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.455
1qorNDPQuinone oxidoreductase 1/0.455
1t4v14AProthrombin3.4.21.50.455
1w06W05Isopenicillin N synthase1.21.3.10.455
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.455
2zjwREFCasein kinase II subunit alpha2.7.11.10.455
3adaNADSubunit alpha of sarocosine oxidase/0.455
3fkoFKOMitogen-activated protein kinase 14/0.455
3l0lHC3Nuclear receptor ROR-gamma/0.455
3uwlFOZThymidylate synthase/0.455
4bj9UHBTankyrase-22.4.2.300.455
4cdmFO1Deoxyribodipyrimidine photolyase/0.455
4fco0U4Beta-secretase 13.4.23.460.455
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.455
4yddMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.455
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.454
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.454
2aviBTNAvidin/0.454
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.454
2idkC2FGlycine N-methyltransferase2.1.1.200.454
3ac1KZITyrosine-protein kinase Lck2.7.10.20.454
3flwFLWMitogen-activated protein kinase 14/0.454
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.454
3tp0FO5HTH-type transcriptional regulator EthR/0.454
3ujlA8SAbscisic acid receptor PYL2/0.454
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
4qe6JN3Bile acid receptor/0.454
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.454
4xybNDPFormate dehydrogenase/0.454
1h6dNDPGlucose--fructose oxidoreductase1.1.99.280.453
2vkmBSDBeta-secretase 13.4.23.460.453
3eigMTXDihydrofolate reductase1.5.1.30.453
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
3i0pNADMalate dehydrogenase, putative/0.453
3ixj586Beta-secretase 13.4.23.460.453
3w0c6DSVitamin D3 receptor/0.453
3w0yDS4Vitamin D3 receptor/0.453
4iv6FDAIsovaleryl-CoA dehydrogenase/0.453
4jq3NAPAldo-keto reductase family 1 member C2/0.453
1d3pBT3Prothrombin3.4.21.50.452
1z71L17Prothrombin3.4.21.50.452
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.452
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.452
2jb4A14Isopenicillin N synthase1.21.3.10.452
2ob0ACON-alpha-acetyltransferase 50/0.452
2wo7ASVIsopenicillin N synthase1.21.3.10.452
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.452
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3hkyIX6Genome polyprotein2.7.7.480.452
3pqbVGPPutative oxidoreductase/0.452
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.452
3up3XCAaceDAF-12/0.452
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.452
4hcy0YNTransketolase/0.452
4jlj1NMDeoxycytidine kinase2.7.1.740.452
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.451
1kr3113Metallo-beta-lactamase type 2/0.451
1qiqACCIsopenicillin N synthase1.21.3.10.451
1re9DSOCamphor 5-monooxygenase1.14.15.10.451
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.451
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.451
3mzhCMPCRP-like cAMP-activated global transcriptional regulator/0.451
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.451
3ska053Genome polyprotein2.7.7.480.451
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.451
4eqsCOACoenzyme A disulfide reductase/0.451
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.451
4ia1BIVVitamin D3 receptor A/0.451
5jscFADPutative acyl-CoA dehydrogenase/0.451
1bsvNDPGDP-L-fucose synthase/0.450
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.450
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.450
1jtuLYBThymidylate synthase/0.450
1mvsDTMDihydrofolate reductase1.5.1.30.450
1uydPU8Heat shock protein HSP 90-alpha/0.450
1x8lOXRRetinol dehydratase/0.450
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.450
2iviACWIsopenicillin N synthase1.21.3.10.450
2j83BATUlilysin3.4.240.450
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.450
2rc6NAPFerredoxin--NADP reductase/0.450
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.450
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3dm6757Beta-secretase 13.4.23.460.450
3ds6A17Mitogen-activated protein kinase 14/0.450
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.450
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3iupNDPPossible NADH oxidoreductase/0.450
3lqfNADGalactitol dehydrogenase/0.450
3p6mDSOCamphor 5-monooxygenase1.14.15.10.450
3q44D50M1 family aminopeptidase3.4.110.450
3qlrNDPDihydrofolate reductase1.5.1.30.450
3qofGDPAtlastin-13.6.50.450
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.450
3vt9YI4Vitamin D3 receptor/0.450
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.450
4phlPILPhosphodiesterase/0.450
4wa9AXITyrosine-protein kinase ABL12.7.10.20.450
5fm7ADPRuvB-like helicase/0.450
1dajMOTDihydrofolate reductase1.5.1.30.449
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1jwtBLIProthrombin3.4.21.50.449
1kceCB3Thymidylate synthase/0.449
1pd9CO4Dihydrofolate reductase1.5.1.30.449
1trgCB3Thymidylate synthase/0.449
2g226IGRenin3.4.23.150.449
2jf6S55Strictosidine-O-beta-D-glucosidase3.2.1.1050.449
2owuSAHDiphthine synthase/0.449
2pa7TYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.449
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.449
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3jpuTY4Transcriptional activator protein LasR/0.449
3o8gO8GHTH-type transcriptional regulator EthR/0.449
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.449
3zm5IGMUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.449
4bj8BTNAvidin/0.449
4l091URTankyrase-22.4.2.300.449
4qbjNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.449
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.449
1pz1NAPGeneral stress protein 69/0.448
1tdrMTXDihydrofolate reductase1.5.1.30.448
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.448
2wyaHMGHydroxymethylglutaryl-CoA synthase, mitochondrial2.3.3.100.448
2yg4FADPutrescine oxidase/0.448
3nguADPNucleoside diphosphate kinase/0.448
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.448
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.448
4c77N01Phenylacetone monooxygenase1.14.13.920.448
4jtqNAPAldo-keto reductase family 1 member C2/0.448
4jzyFADCryptochrome-1/0.448
4mihFADPyranose 2-oxidase1.1.3.100.448
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.448
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.448
5k2dZMAAdenosine receptor A2a/0.448
3qakUKAAdenosine receptor A2a/0.448
3emlZMAAdenosine receptor A2a/0.448
1dgbNDPCatalase1.11.1.60.447
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.447
1uzwCDHIsopenicillin N synthase1.21.3.10.447
2d29FADAcyl-CoA dehydrogenase/0.447
2fhlBNIAvidin-related protein 4/5/0.447
2q5qKPVIndole-3-pyruvate decarboxylase4.1.1.740.447
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.447
3d7zGK5Mitogen-activated protein kinase 14/0.447
3e92G6AMitogen-activated protein kinase 14/0.447
3n1s5GPPurine nucleoside phosphoramidase/0.447
3qbhQBHBeta-secretase 13.4.23.460.447
3tm5SFGUncharacterized protein/0.447
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.447
4g1y0VOVitamin D3 receptor A/0.447
4g2i0VQVitamin D3 receptor/0.447
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.447
4gutFADLysine-specific histone demethylase 1B10.447
4n3r2GUTankyrase-12.4.2.300.447
4xnhACON-terminal acetyltransferase A complex subunit NAT52.3.10.447
1avdBTNAvidin/0.446
1d9i00PProthrombin3.4.21.50.446
1vceSAHDiphthine synthase/0.446
1x1bSAHC-20 methyltransferase/0.446
2c12FADNitroalkane oxidase1.7.3.10.446
2cf8ESHProthrombin3.4.21.50.446
2cmvNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.446
2hdjNDPAldo-keto reductase family 1 member C2/0.446
2pswCOAN-alpha-acetyltransferase 50/0.446
2vcgS17Histone deacetylase-like amidohydrolase3.5.10.446
2x6o2TCTetracycline repressor protein class D/0.446
2y60M8FIsopenicillin N synthase1.21.3.10.446
2zfnACOHistone acetyltransferase RTT1092.3.1.480.446
3arvSAUChitinase A/0.446
3l6jZ90Alr2278 protein/0.446
3q0vLL4HTH-type transcriptional regulator EthR/0.446
3up0D7SaceDAF-12/0.446
3zm62GNUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.446
4bfwZVWPantothenate kinase2.7.1.330.446
4d04NAPPhenylacetone monooxygenase1.14.13.920.446
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.446
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
5kf1ACOPredicted acetyltransferase/0.446
1ie9VDXVitamin D3 receptor/0.445
2b03TUDPhospholipase A2, major isoenzyme3.1.1.40.445
2hveADPNucleoside diphosphate kinase A2.7.4.60.445
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.445
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.445
2yimMC4Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.445
3c5uP41Mitogen-activated protein kinase 14/0.445
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.445
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3h0bB35Beta-secretase 13.4.23.460.445
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3slkNDPPolyketide synthase extender module 2/0.445
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.445
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
4bfvZVVPantothenate kinase2.7.1.330.445
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.445
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4j6dTESCytochrome P450 monooxygenase/0.445
4oviN01Phenylacetone monooxygenase1.14.13.920.445
4q0a4OAVitamin D3 receptor A/0.445
4u8iFDAUDP-galactopyranose mutase/0.445
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.444
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.444
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.444
1h35R01Squalene--hopene cyclase4.2.1.1290.444
1r2jFADFkbI/0.444
2ofv242Tyrosine-protein kinase Lck2.7.10.20.444
2vbdV10Isopenicillin N synthase1.21.3.10.444
2vq7FADPutative flavin-containing monooxygenase/0.444
2xveFADPutative flavin-containing monooxygenase/0.444
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.444
2zbaZBATrichothecene 3-O-acetyltransferase/0.444
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.444
3h4vDVPPteridine reductase 11.5.1.330.444
3jynNDPQuinone oxidoreductase/0.444
3lpkZ76Beta-secretase 13.4.23.460.444
3vtcTK3Vitamin D3 receptor/0.444
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.444
3zsh469Mitogen-activated protein kinase 14/0.444
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.444
4eqwCOACoenzyme A disulfide reductase/0.444
4fhi0S4Vitamin D3 receptor A/0.444
4gl4NAIAlcohol dehydrogenase class-3/0.444
4h6uACOAlpha-tubulin N-acetyltransferase 1/0.444
4jlk1NODeoxycytidine kinase2.7.1.740.444
4klaCHDFerrochelatase, mitochondrial4.99.1.10.444
4ubtCOASteroid 3-ketoacyl-CoA thiolase/0.444
4z24FADPutative GMC-type oxidoreductase R13510.444
1gc5ADPADP-dependent glucokinase2.7.1.1470.443
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.443
1o6qR17Squalene--hopene cyclase4.2.1.1290.443
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.443
1zs6ADPNucleoside diphosphate kinase 32.7.4.60.443
2geuCOKPantothenate kinase2.7.1.330.443
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.443
2w4qCBWProstaglandin reductase 21.3.1.480.443
3dr1C5DVitamin D3 receptor A/0.443
3eq6BCOAcyl-coenzyme A synthetase ACSM2A, mitochondrial6.2.1.20.443
3h3sH15Collagen type IV alpha-3-binding protein/0.443
3hub469Mitogen-activated protein kinase 14/0.443
3s7a684Dihydrofolate reductase1.5.1.30.443
3vtdTKDVitamin D3 receptor/0.443
3w78CBDFMN-dependent NADH-azoreductase/0.443
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.443
4b78KGGBeta-secretase 13.4.23.460.443
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.443
4dbs0HVAldo-keto reductase family 1 member C3/0.443
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.443
4iqqD16Thymidylate synthase/0.443
4l1xNAPAldo-keto reductase family 1 member C2/0.443
4wdgA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
4s0vSUVOrexin receptor type 2/0.443
1fwmCB3Thymidylate synthase/0.442
1ie8KH1Vitamin D3 receptor/0.442
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.442
1jpaANPEphrin type-B receptor 22.7.10.10.442
1nm6L86Prothrombin3.4.21.50.442
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]/0.442
1yplRA8Prothrombin3.4.21.50.442
2cbrA80Cellular retinoic acid-binding protein 1/0.442
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
2ebaFADPutative glutaryl-CoA dehydrogenase/0.442
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.442
2ok8FADFerredoxin--NADP reductase, apicoplast/0.442
2uxhQUEHTH-type transcriptional regulator TtgR/0.442
3bac3B9DNA ligase/0.442
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3n1t5GPPurine nucleoside phosphoramidase/0.442
3ol5SAWCamphor 5-monooxygenase1.14.15.10.442
3pg3DG7Mitogen-activated protein kinase 14/0.442
4aosFADSteroid monooxygenase/0.442
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.442
4epq0RRPoly(ADP-ribose) glycohydrolase/0.442
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.442
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.442
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
4nieNBHNuclear receptor ROR-gamma/0.442
4qmpDKISerine/threonine-protein kinase 242.7.11.10.442
4v12POGMaoC like domain protein/0.442
4zm6ACON-acetyl-beta-D glucosaminidase/0.442
1ipeNDPTropinone reductase 21.1.1.2360.441
1kkq471Peroxisome proliferator-activated receptor alpha/0.441
1knrFADL-aspartate oxidase1.4.3.160.441
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.441
1nzq162Prothrombin3.4.21.50.441
1ri2GTGmRNA cap guanine-N7 methyltransferase2.1.1.560.441
1s0zEB1Vitamin D3 receptor/0.441
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
1tysDHFThymidylate synthase/0.441
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.441
2bu9HFVIsopenicillin N synthase1.21.3.10.441
2fy5SOPCholine O-acetyltransferase2.3.1.60.441
2oalFADFlavin-dependent tryptophan halogenase RebH1.14.19.90.441
2p4yC03Peroxisome proliferator-activated receptor gamma/0.441
2v3oI26Prothrombin3.4.21.50.441
2wmeNAPNAD/NADP-dependent betaine aldehyde dehydrogenase/0.441
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.441
3ad9NADSubunit alpha of sarocosine oxidase/0.441
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.441
3fznD7KBenzoylformate decarboxylase4.1.1.70.441
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.441
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.441
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.441
3sfeFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.441
3tfyCOAN-alpha-acetyltransferase 502.3.10.441
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.441
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.441
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.441
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
5dbgNADIridoid synthase1.3.1.990.441
5kf9ACOPredicted acetyltransferase/0.441
1bq1CB3Thymidylate synthase/0.440
1cm0COAHistone acetyltransferase KAT2B2.3.1.480.440
1g3mPCQEstrogen sulfotransferase2.8.2.40.440
1g6nCMPcAMP-activated global transcriptional regulator CRP/0.440
1icqOPD12-oxophytodienoate reductase 11.3.1.420.440
1kvkATPMevalonate kinase2.7.1.360.440
1kzjCB3Thymidylate synthase/0.440
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1p8dCO1Oxysterols receptor LXR-beta/0.440
1txtCAAHMG-CoA synthase/0.440
1xs7MMIBeta-secretase 13.4.23.460.440
2b9xFADPutative aminooxidase/0.440
2dshSAHDiphthine synthase/0.440
2lbaCHOFatty acid binding protein 6/0.440
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2p9hIPTLactose operon repressor/0.440
2xlrFADPutative flavin-containing monooxygenase/0.440
2y3rTRKTamL/0.440
3bgxMEFThymidylate synthase/0.440
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.440
3lfeZ84Mitogen-activated protein kinase 14/0.440
3nx4NAPPutative oxidoreductase/0.440
3qe2FMNNADPH--cytochrome P450 reductase/0.440
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.440
4cavMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.440
4dlcUMPDeoxyuridine triphosphatase, putative/0.440
4eiyZMAAdenosine receptor A2a/0.440
4i1nFOLDihydrofolate reductase1.5.1.30.440
4j6bPLOCytochrome P450 monooxygenase/0.440
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.440
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.440
5d1bTSNHistone deacetylase 83.5.1.980.440
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.440
5jy1NADPutative short-chain dehydrogenase/reductase/0.440
5iu86DZAdenosine receptor A2a/0.440