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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase/1.000
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.490
4dnaFADProbable glutathione reductase/0.476
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.470
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.468
1typFADTrypanothione reductase1.8.1.120.466
4la1FADThioredoxin glutathione reductase/0.465
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.462
2hqmFADGlutathione reductase1.8.1.70.458
4h4vFADBiphenyl dioxygenase ferredoxin reductase subunit/0.458
1grhFADGlutathione reductase, mitochondrial1.8.1.70.454
4gavFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.454
4h4pFADBiphenyl dioxygenase ferredoxin reductase subunit/0.453
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.452
1grgFADGlutathione reductase, mitochondrial1.8.1.70.451
3grsFADGlutathione reductase, mitochondrial1.8.1.70.451
4em4FADCoenzyme A disulfide reductase/0.451
1graFADGlutathione reductase, mitochondrial1.8.1.70.448
4eqwFADCoenzyme A disulfide reductase/0.448
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.448
4h4uFADBiphenyl dioxygenase ferredoxin reductase subunit/0.448
2v6oFADThioredoxin glutathione reductase/0.446
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.446
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.444
1febFADTrypanothione reductase1.8.1.120.441
2jk6FADTrypanothione reductase/0.441
4h4wFADBiphenyl dioxygenase ferredoxin reductase subunit/0.441