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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5e8wSTUTGF-beta receptor type-12.7.11.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5e8wSTUTGF-beta receptor type-12.7.11.301.000
2wotZZGTGF-beta receptor type-12.7.11.300.610
3gxlQIGTGF-beta receptor type-12.7.11.300.587
1vjy460TGF-beta receptor type-12.7.11.300.551
1bygSTUTyrosine-protein kinase CSK/0.540
4dymIYZActivin receptor type-12.7.11.300.528
1rw8580TGF-beta receptor type-12.7.11.300.524
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.524
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.520
4bgg844Activin receptor type-12.7.11.300.515
1u4dDBQActivated CDC42 kinase 1/0.511
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.510
3hmm855TGF-beta receptor type-12.7.11.300.509
3mtfA3FActivin receptor type-12.7.11.300.509
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.508
5e8xSTUTGF-beta receptor type-12.7.11.300.507
4qmpDKISerine/threonine-protein kinase 242.7.11.10.504
4c02TAKActivin receptor type-12.7.11.300.502
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.501
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.498
4jia1K3Tyrosine-protein kinase JAK2/0.495
2qo9ANPEphrin type-A receptor 32.7.10.10.494
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.493
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.493
2iw84SPCyclin-dependent kinase 22.7.11.220.492
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.489
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.488
4gmy0X5Tyrosine-protein kinase JAK2/0.488
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.487
3zewSTUEphrin type-B receptor 42.7.10.10.486
3uyt0CKCasein kinase I isoform delta2.7.11.10.485
4c61LMMTyrosine-protein kinase JAK2/0.485
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.484
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.484
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.483
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.483
1u54ACPActivated CDC42 kinase 1/0.482
2iw94SPCyclin-dependent kinase 22.7.11.220.482
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.482
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.482
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.482
1g5sI17Cyclin-dependent kinase 22.7.11.220.481
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.480
2j0m4STFocal adhesion kinase 12.7.10.20.479
2yn8STUEphrin type-B receptor 42.7.10.10.479
4riyADPEpidermal growth factor receptor2.7.10.10.479
4e4m0NHTyrosine-protein kinase JAK2/0.478
4i22IREEpidermal growth factor receptor2.7.10.10.478
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.477
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.477
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.476
3gubGUBDeath-associated protein kinase 12.7.11.10.476
3i60E86Mitogen-activated protein kinase 12.7.11.240.476
1xjdSTUProtein kinase C theta type2.7.11.130.475
2vx17X8Ephrin type-B receptor 42.7.10.10.475
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.475
3oom507Activin receptor type-12.7.11.300.474
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.474
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.474
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.474
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.473
4qmzB49Serine/threonine-protein kinase 242.7.11.10.473
1h1s4SPCyclin-dependent kinase 22.7.11.220.472
2x1nX1NCyclin-dependent kinase 22.7.11.220.472
3vryB43Tyrosine-protein kinase HCK2.7.10.20.472
4erwSTUCyclin-dependent kinase 22.7.11.220.472
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.472
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.471
2vwz7X6Ephrin type-B receptor 42.7.10.10.471
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.471
5e92ANPTGF-beta receptor type-22.7.11.300.471
1py5PY1TGF-beta receptor type-12.7.11.300.470
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.470
4ewhT77Activated CDC42 kinase 1/0.470
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.470
1pyePM1Cyclin-dependent kinase 22.7.11.220.469
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.469
3ddpRC8Cyclin-dependent kinase 22.7.11.220.469
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.469
4hvi19STyrosine-protein kinase JAK32.7.10.20.469
2xa4AZ5Tyrosine-protein kinase JAK2/0.468
3be9P04Casein kinase II subunit alpha2.7.11.10.468
2vx07X7Ephrin type-B receptor 42.7.10.10.467
3l8p0CEAngiopoietin-1 receptor2.7.10.10.467
4bb432WEphrin type-B receptor 42.7.10.10.466
4hvh19RTyrosine-protein kinase JAK32.7.10.20.466
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.465
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.465
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.465
4gk2L66Ephrin type-A receptor 32.7.10.10.465
4hge15VTyrosine-protein kinase JAK2/0.465
2vwx7X4Ephrin type-B receptor 42.7.10.10.464
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.464
1pmn984Mitogen-activated protein kinase 102.7.11.240.463
3uli1N3Cyclin-dependent kinase 22.7.11.220.463
1om1IQACasein kinase II subunit alpha2.7.11.10.462
2i40BLZCyclin-dependent kinase 22.7.11.220.462
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.462
3zep1NXTyrosine-protein kinase JAK32.7.10.20.462
4j97ACPFibroblast growth factor receptor 2/0.462
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.462
1e9hINRCyclin-dependent kinase 22.7.11.220.461
2in6839Wee1-like protein kinase2.7.10.20.461
2of4979Tyrosine-protein kinase Lck2.7.10.20.461
2xvdAS6Ephrin type-B receptor 42.7.10.10.461
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.461
1eh4IC1Casein kinase I homolog 12.7.11.10.460
2zdt46CMitogen-activated protein kinase 102.7.11.240.460
3zh8C58Protein kinase C iota type2.7.11.130.460
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.460
5drdATPAurora kinase A2.7.11.10.460
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.459
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.459
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.459
5cnnANPEpidermal growth factor receptor2.7.10.10.459
2xikJ60Serine/threonine-protein kinase 252.7.11.10.458
4lopSB4Mitogen-activated protein kinase 14/0.458
4uymVOR14-alpha sterol demethylase Cyp51B/0.458
4yuqKS1Calmodulin-like domain protein kinase/0.458
1pkdUCNCyclin-dependent kinase 22.7.11.220.457
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.457
2vwy7X5Ephrin type-B receptor 42.7.10.10.457
2x9fX9FEphrin type-B receptor 42.7.10.10.457
3rk507ZCyclin-dependent kinase 22.7.11.220.457
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.457
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.457
1oiyN41Cyclin-dependent kinase 22.7.11.220.456
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.456
4hnf16WCasein kinase I isoform delta2.7.11.10.456
4kbk1QGCasein kinase I isoform delta2.7.11.10.456
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.456
1y91CT9Cyclin-dependent kinase 22.7.11.220.454
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.454
3ggfGVDSerine/threonine-protein kinase 26/0.454
4dgnLU2Casein kinase II subunit alpha2.7.11.10.454
4g2fC07Ephrin type-A receptor 32.7.10.10.454
4jqeANPCasein kinase II subunit alpha2.7.11.10.454
4q71FADBifunctional protein PutA/0.454
1di8DTQCyclin-dependent kinase 22.7.11.220.453
1h1r6CPCyclin-dependent kinase 22.7.11.220.453
2wxvWXVCyclin-dependent kinase 22.7.11.220.453
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.453
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3iok1P6Tyrosine-protein kinase JAK2/0.453
3uzp0CKCasein kinase I isoform delta2.7.11.10.453
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.453
5e8ySTUTGF-beta receptor type-22.7.11.300.453
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.452
3bi6396Wee1-like protein kinase2.7.10.20.452
4aqc88ATyrosine-protein kinase JAK2/0.452
4gk3L87Ephrin type-A receptor 32.7.10.10.452
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.452
4nk92K5Fibroblast growth factor receptor 1/0.452
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.452
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.451
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.451
2w05FRTCyclin-dependent kinase 22.7.11.220.451
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.451
4bcpT3CCyclin-dependent kinase 22.7.11.220.451
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.451
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.451
4k33ACPFibroblast growth factor receptor 32.7.10.10.451
1m2pHNACasein kinase II subunit alpha2.7.11.10.450
1oi9N20Cyclin-dependent kinase 22.7.11.220.450
2j0j4STFocal adhesion kinase 12.7.10.20.450
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.450
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.450
3kvxFMYMitogen-activated protein kinase 102.7.11.240.450
3ttjJBIMitogen-activated protein kinase 102.7.11.240.450
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.450
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.450
1aq1STUCyclin-dependent kinase 22.7.11.220.449
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.449
2j0k4STFocal adhesion kinase 12.7.10.20.449
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.449
2wpa889Cyclin-dependent kinase 22.7.11.220.449
3rmf20ZCyclin-dependent kinase 22.7.11.220.449
3vs1VSATyrosine-protein kinase HCK2.7.10.20.449
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.449
4fod0UVALK tyrosine kinase receptor2.7.10.10.449
4id71G0Activated CDC42 kinase 1/0.449
4jq8KJ8Epidermal growth factor receptor2.7.10.10.449
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1fvv107Cyclin-dependent kinase 22.7.11.220.448
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.448
2b7aIZATyrosine-protein kinase JAK2/0.448
2eufLQQCyclin-dependent kinase 62.7.11.220.448
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.448
3t2zFADSulfide-quinone reductase/0.448
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.448
4hvg19QTyrosine-protein kinase JAK32.7.10.20.448
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.448
1oiuN76Cyclin-dependent kinase 22.7.11.220.447
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.447
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.447
1xkkFMMEpidermal growth factor receptor2.7.10.10.447
2pmdGNPTranslation initiation factor 2 subunit gamma/0.447
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.447
3ttiKBIMitogen-activated protein kinase 102.7.11.240.447
2of2547Tyrosine-protein kinase Lck2.7.10.20.446
2xyuQ9GEphrin type-A receptor 42.7.10.10.446
4fob0USALK tyrosine kinase receptor2.7.10.10.446
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.446
4kb81QNCasein kinase I isoform delta2.7.11.10.446
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
2cchATPCyclin-dependent kinase 22.7.11.220.445
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
2pmoHMDProtein kinase 7/0.445
2qoqANPEphrin type-A receptor 32.7.10.10.445
2y6o1N1Ephrin type-A receptor 42.7.10.10.445
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.445
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.445
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.445
1gih1PUCyclin-dependent kinase 22.7.11.220.444
1jpaANPEphrin type-B receptor 22.7.10.10.444
1uyePU9Heat shock protein HSP 90-alpha/0.444
2p33J07Mitogen-activated protein kinase 102.7.11.240.444
2uzbC75Cyclin-dependent kinase 22.7.11.220.444
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.444
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.444
3gu83GUDeath-associated protein kinase 12.7.11.10.444
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.444
3w33W19Epidermal growth factor receptor2.7.10.10.444
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
4eok4SPCyclin-dependent kinase 22.7.11.220.444
1ke6LS2Cyclin-dependent kinase 22.7.11.220.443
1yvj4STTyrosine-protein kinase JAK32.7.10.20.443
3w32W32Epidermal growth factor receptor2.7.10.10.443
4fv6E57Mitogen-activated protein kinase 12.7.11.240.443
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.443
1gij2PUCyclin-dependent kinase 22.7.11.220.442
1gqtACPRibokinase/0.442
1oguST8Cyclin-dependent kinase 22.7.11.220.442
1ol5ADPAurora kinase A2.7.11.10.442
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3hz5Z64Heat shock protein HSP 90-alpha/0.442
3rk708ZCyclin-dependent kinase 22.7.11.220.442
3t8oATPRhodopsin kinase/0.442
3vt7VDXVitamin D3 receptor/0.442
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4xj3GTPCyclic GMP-AMP synthase/0.442
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.441
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1vyw292Cyclin-dependent kinase 22.7.11.220.441
2pvhP19Casein kinase II subunit alpha2.7.11.10.441
2pwlACPFibroblast growth factor receptor 2/0.441
3r9oZ71Cyclin-dependent kinase 22.7.11.220.441
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.441
4f081RSTyrosine-protein kinase JAK2/0.441
4j95ACPFibroblast growth factor receptor 2/0.441
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.441
1bwsNDPGDP-L-fucose synthase/0.440
1csnATPCasein kinase I homolog 12.7.11.10.440
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.440
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.440
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.440
3zptM8YGag-Pol polyprotein3.4.23.160.440
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.440
4gk4L90Ephrin type-A receptor 32.7.10.10.440