Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5dr9SKEAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5dr9SKEAurora kinase A2.7.11.11.000
5dt0SKEAurora kinase A2.7.11.10.616
5dpvSKEAurora kinase A2.7.11.10.586
5dr6SKEAurora kinase A2.7.11.10.557
2x6dX6DAurora kinase A2.7.11.10.534
3k5uPFQAurora kinase A2.7.11.10.519
2w1fL0FAurora kinase A2.7.11.10.517
2dwbANPAurora kinase A2.7.11.10.513
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.500
4o0wADNAurora kinase A2.7.11.10.499
4jajXU1Aurora kinase A2.7.11.10.494
4jbpYPHAurora kinase A2.7.11.10.494
5drdATPAurora kinase A2.7.11.10.491
2xru400Aurora kinase A2.7.11.10.488
4gmy0X5Tyrosine-protein kinase JAK2/0.488
4o0sADNAurora kinase A2.7.11.10.488
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.486
1ol5ADPAurora kinase A2.7.11.10.480
4deeADPAurora kinase A2.7.11.10.478
5dt3ATPAurora kinase A2.7.11.10.478
4deaNHIAurora kinase A2.7.11.10.477
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.475
4o0uADNAurora kinase A2.7.11.10.474
5dosATPAurora kinase A2.7.11.10.473
5dt4ATPAurora kinase A2.7.11.10.473
2np8CC3Aurora kinase A2.7.11.10.470
4hvg19QTyrosine-protein kinase JAK32.7.10.20.469
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.464
3w18N13Aurora kinase A2.7.11.10.462
4hvi19STyrosine-protein kinase JAK32.7.10.20.460
4jbqVX6Aurora kinase A2.7.11.10.460
5dn3ATPAurora kinase A2.7.11.10.460
3uo50BXAurora kinase A2.7.11.10.459
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.459
4jboWPHAurora kinase A2.7.11.10.456
3emg685Tyrosine-protein kinase SYK2.7.10.20.455
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.455
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.454
1mq4ADPAurora kinase A2.7.11.10.453
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.453
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.452
4hvh19RTyrosine-protein kinase JAK32.7.10.20.452
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.451
2w1eL0EAurora kinase A2.7.11.10.450
2xngA0HAurora kinase A2.7.11.10.450
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
1wvxBD4Death-associated protein kinase 12.7.11.10.448
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.447
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.447
3a62STURibosomal protein S6 kinase beta-12.7.11.10.446
3be9P04Casein kinase II subunit alpha2.7.11.10.446
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.446
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.446
4c3rACPAurora kinase A2.7.11.10.445
4utdACPAurora kinase A2.7.11.10.445
3ezvEZVCyclin-dependent kinase 22.7.11.220.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
1fvv107Cyclin-dependent kinase 22.7.11.220.443
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.442
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3gxlQIGTGF-beta receptor type-12.7.11.300.442
4bbfO19Tyrosine-protein kinase JAK2/0.442
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.441
2hog710Serine/threonine-protein kinase Chk12.7.11.10.441
5dnrATPAurora kinase A2.7.11.10.440